A method and preliminary results of <i>in silico</i> computer simulation for the formation of mix thrombi with platelet and fibrin

Abstract

Formation of thrombi is a complex biological event involving platelets and coagulation cascades. The both have been well investigated individually. However, the interrelationship between them is still to be elucidated. The recent progresses in computer technology may allow us to simulate complex biological phenomena in silico. Here we report a novel method to reproduce the complex system of the interrelationship between platelet and coagulation by combining the previous simulation model of platelet adhesion with the model of coagulation cascade. We have reproduced the biological process of thrombus growth occurring in the mice cremasteric artery induced by endothelial injury by FeCl 3 with our newly developed computer simulator.

Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them

“…Blood flow around stent struts were calculated by solving the discretized Navier–Stokes equation [ 27 , 29 , 30 ]. Briefly, the diameter of the target vessel was set to 3 mm.…”

“…The mechanism of an increased risk of stent thrombosis in patients with stent malapposition is not understood [ 23 , 27 ]. This lack of understanding creates a barrier for developing new treatment protocols.…”

“…Recent advances in the calculation power of computer and information technology facilitates in silico analysis by constructing various complicated biological phenomena such as thrombus formation by solving basic physical/chemical equations [ 27 , 29 , 30 ]. Using this technology, computer simulation models of platelets adhesion under various blood flow conditions were developed [ 29 ].…”