Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation

Takeda, Tomohiro; Unno, Hirotoshi; Morita, Hideaki; Futamura, Kenta; Emi-Sugie, Maiko; Arae, Ken; Shoda, Tetsuo; Okada, Naoko; Igarashi, Arisa; Inoue, Eisuke; Kitazawa, Hiroshi; Nakae, Susumu; Saito, Hirohisa; Matsumoto, Kenji; Matsuda, Akio

doi:10.1016/j.jaci.2016.01.032

Cited by 47 publications

(45 citation statements)

References 56 publications

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“…1) [39]. In food allergy and anaphylaxis research, novel techniques were developed allowing the in-vivo monitoring of effects by allergen challenges, and, in accordance with the 3R principle, networks are formed to share tissues [70]. Future research directions may address the development of novel engineered mouse models facilitating the investigation of single-target molecules, whereas domestic animals represent natural animal models, spontaneously developing asthma, food allergy and anaphylaxis with immune mechanisms more similar to human allergy.…”

Section: Resultsmentioning

confidence: 99%

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Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis

Jensen‐Jarolim

Pali‐Schöll

Roth‐Walter

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewAnimal models published within the past 18 months on asthma, food allergy and anaphylaxis, all conditions of rising public health concern, were reviewed.Recent findingsWhile domestic animals spontaneously develop asthma, food allergy and anaphylaxis, in animal models, divergent sensitization and challenge routes, dosages, intervals and antigens are used to induce asthmatic, food allergic or anaphylactic phenotypes. This must be considered in the interpretation of results. Instead of model antigens, gradually relevant allergens such as house dust mite in asthma, and food allergens like peanut, apple and peach in food allergy research were used. Novel engineered mouse models such as a mouse with a T-cell receptor for house dust mite allergen Der p 1, or with transgenic human hFcγR genes, facilitated the investigation of single molecules of interest. Whole-body plethysmography has become a state-of-the-art in-vivo readout in asthma research. In food allergy and anaphylaxis research, novel techniques were developed allowing real-time monitoring of in-vivo effects following allergen challenge. Networks to share tissues were established as an effort to reduce animal experiments in allergy which cannot be replaced by in-vitro measures.SummaryNatural and artificial animal models were used to explore the pathophysiology of asthma, food allergy and anaphylaxis and to improve prophylactic and therapeutic measures. Especially the novel mouse models mimicking molecular aspects of the complex immune network in asthma, food allergy and anaphylaxis will facilitate proof-of-concept studies under controlled conditions.

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Section: Resultsmentioning

confidence: 99%

“…The study highlighted the importance of IL-33 and mast cells to trigger anaphylaxis and might lead to novel anti-IL-33 therapeutics in humans [69]. Interestingly platelets, which participate in the anaphylactic reaction, have proven a significant source of IL-33 in humans as well as in an airway eosinophilia model in mice [70]. …”

Section: Introductionmentioning

confidence: 99%

Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis

Jensen‐Jarolim

Pali‐Schöll

Roth‐Walter

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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“…In addition, IL-33 has been shown to mediate eosinophilo-poesis in response to Alternaria and enhance IL-5 expression by ILC2’s in the lungs. (24) This study along with a report by Takeda(25) which demonstrated that human platelets are a source of IL-33 implicate the importance of this cytokine in airway inflammation which may occur in response to environmental allergen exposure. Additionally, the interaction of genetics and fungal exposures has been investigated.…”

Section: Responses To Environmental Fungimentioning

confidence: 58%

Advances in environmental and occupational disorders in 2016

Sheehan

Gaffin

Peden

et al. 2017

Journal of Allergy and Clinical Immunology

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In this review, we highlight recent studies that advance the knowledge and understanding of the effects of various environmental factors and the associated immune responses in patients with allergic diseases. This review will focus on new literature regarding allergic and immune responses to a variety of environmental factors including aeroallergens, stinging insects, fungi, pollutants, viral respiratory infections, climate change, and microbial exposures.

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“…33 In addition, platelet-derived IL-33 was recently suggested to induce eosinophilic airway inflammation. 34 On the other hand, PF4 was found to be a negative regulator of Th17 differentiation, thereby limiting cardiac allograft rejection in a murine cardiac transplant model. 35 Platelets also release microparticles, which are small extracellular vesicles (the majority are ;200 nm in diameter) produced via blebbing and fission of the plasma membrane.…”

mentioning

confidence: 99%