Platelets as an indicator of vascular repair in elderly Japanese men

Shimizu, Yūji; Sato, Shimpei; Koyamatsu, Jun; Yamanashi, Hirotomo; Nagayoshi, Mako; Kadota, Koichiro; Maeda, Takahiro

doi:10.18632/oncotarget.10229

Cited by 30 publications

(73 citation statements)

References 26 publications

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“…without hypertension, whereas no significant association was observed for subjects with hypertension. In addition, this previous study revealed that platelet count was not significantly associated with CIMT among subjects without hypertension but that it significantly positively associated with CIMT among those with hypertension 34 . These findings support the above-mentioned mechanism, showing that the status of hypertension could be associated with wasting reduction of circulating CD34-positive cells.…”

Section: Discussionmentioning

confidence: 79%

“…Hypertension masks the beneficial effect of CD34+ cells 5,34 and low levels of CD34+ cells acts as an indicator of the activity of the vicious cycle that exists between hypertension and endothelial dysfunction as evaluated using CIMT 6 . Since the present study aimed to clarify the influence of CD34+ cells on active arterial wall thickening, hypertension status-specific analyses were performed.…”

Section: Discussionmentioning

confidence: 99%

“…Since the present study aimed to clarify the influence of CD34+ cells on active arterial wall thickening, hypertension status-specific analyses were performed. We defined hypertension according to previous studies 5,6,34 , namely, systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg. The characteristics of the study population in terms of hypertension status were expressed as mean ± standard deviation for normally distributed contentious variables.…”

Section: Discussionmentioning

confidence: 99%

“…Platelets contribute to endothelial repair (vascular maintenance) in conjunction with CD34+ cells 17,25,34 . However, the ratio of the decrease in the platelet count due to their use in endothelial repair might be much smaller than that of circulating CD34+ cells in patients with hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…www.nature.com/scientificreports www.nature.com/scientificreports/ Association between circulating CD34+ cells and platelets by hypertension. As the combination of platelets and circulating CD34+ cells could act as an indicators of aggressive endothelial repair, which relates to wasting reduction of CD34+ cells 6,34 , we also evaluated the association between circulating CD34+ cells and platelets. The simple correlation coefficient showed a significant positive association between circulating CD34+ cells and platelets only for subjects without hypertension.…”

Section: Effect Of the Modification Of Hypertension On The Associatiomentioning

confidence: 99%

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Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study

Shimizu

Kawashiri

Kiyoura

et al. 2020

Sci Rep

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Age-related physical changes, such as low-grade inflammation and increased oxidative stress, induce endothelial repair and cause active arterial wall thickening by stimulating the production of CD34+ cells (the principal mediators of atherosclerosis). Despite this, aggressive endothelial repair (progressing atherosclerosis) might cause a wasting reduction in CD34+ cells, which could result in a lower capacity of endothelial repair and hypertension. As yet, no prospective study has clarified the association of circulating CD34+ cells with active arterial wall thickening. We conducted a prospective study of 363 men aged 60-69 years who participated in a general health checkup at least twice from 2014-2017. The circulating CD34+ cell count was significantly positively associated with active arterial wall thickening among subjects without hypertension (n = 236), but not among subjects with hypertension (n = 127). The fully adjusted odds ratios (ORs) of active arterial wall thickening for the logarithmic circulating CD34+ cell count were 1.83 (1.19, 2.84) and 0.69 (0.36, 1.32) for subjects without and with hypertension, respectively. Circulating CD34+ cells are positively associated with active arterial wall thickening in subjects without hypertension. this study demonstrates a means to clarify the mechanisms of endothelial repair in elderly subjects. Recently, bone marrow-derived hematopoietic stem cells (immature cells, such as CD34+ cells) have been revealed to play a major role in vascular homeostasis 1-3. It is likely that the number of circulating CD34+ cells could indicate the capacity of endothelial maintenance 4-6. However, it is known that hematopoietic bone marrow activity declines with age 7-10 , which might induce a lower capacity of endothelial maintenance in elderly subjects. Furthermore, aging is a well-known cause of endothelial injury 11,12 which subsequently induces endothelial repair. In addition, the aggressive endothelial repair that causes atherosclerosis might induce a wasting reduction of circulating CD34+ cells 6,13 which result in a shortage of the mediators of endothelial repair. Moreover, inadequate endothelial repair might cause hypertension in elderly individuals 14. These previous studies indicate that there are close connections among the age-related decline of bone marrow activity, age-related endothelial injury, and the wasting reduction of circulating CD34+ cells. Platelets are also known to play an important role in vascular inflammation and vessel wall remodeling 15,16. Indeed, platelets promote the mobilization of bone marrow-derived CD34+ cells into the peripheral blood 17-21 , and CD34+ cells also induce platelet elevation 22,23. Furthermore, platelets have been reported to play an important role in the initial development of atherosclerotic lesions 24 , and not only induce the differentiation of human CD34+ cells into endothelial cells, but also into foam cells, which contribute to the development of atherosclerosis 25. Therefore, platelets also play an important role in the a...

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Effect Of the Modification Of Hypertension On The Associatiomentioning

confidence: 99%

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Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study

Shimizu

Kawashiri

Kiyoura

et al. 2020

Sci Rep

Self Cite

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Non‐genetic biomarkers for ankylosing spondylitis: An umbrella review

Zhu

et al. 2022

Clinical Laboratory Analysis

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Objective The objective of the study was to provide an overview of the existing evidence on non‐genetic biomarkers for ankylosing spondylitis (AS). Methods In this umbrella review, we searched PubMed and Web of Science from database inception to October 31, 2020. Systematic reviews and meta‐analyses of observational studies investigating the associations between any non‐genetic biomarkers and AS were included. We estimated summary standardized mean difference (SMD) along with 95% confidence interval (CI), I2 statistic, 95% prediction interval (PI), and assessed small‐study effects and excess significance bias. The study was registered in PROSPERO with registration number of CRD42020218240. Results A total of 1276 publications were identified, of which 21 articles covering 43 non‐genetic biomarkers were eligible for inclusion. Evidence of 22 (51%) non‐genetic biomarkers exhibited a nominally significant effect (p < 0.05) on AS, and 7 associations (14%) showed small‐study effects. The associations of platelet count (SMD: 0.53, 95% CI: 0.36 to 0.71) and serum interleukin (IL)‐23 levels (SMD = 2.03, 95% CI: 1.27 to 2.79) with AS presented highly suggestive evidence, while circulating IL‐17 levels (SMD = 2.36, 95% CI: 1.71, 3.01) and Treg/PBMC ratio (SMD = −0.75, 95% CI: −1.06 to −0.44) presented suggestive evidence. However, these associations showed large or very large between‐study heterogeneity, suggesting an indefinite direction for the effect when 95% PIs were considered. Conclusion No convincing evidence supported the existence of a non‐genetic biomarker for AS. Some highly suggestive associations might be affected by bias, therefore, promising non‐genetic biomarkers for AS remain limited at least based on the current evidence from observational studies.

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