Insulin-Like Growth Factor-1 (IGF-1) and Reduced Tongue Pressure in Relation to Atherosclerosis Among Community-Dwelling Elderly Japanese Men: A Cross-Sectional Study

Shimizu, Yūji; Yamanashi, Hirotomo; Noguchi, Yuko; Koyamatsu, Jun; Higashi, Miho; Fukui, Shoichi; Kawashiri, Shin‐ya; Arima, Kei; Takamura, Noboru; Maeda, Takahiro

doi:10.1007/s00455-020-10096-0

Cited by 2 publications

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References 22 publications

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“…This study provided novel evidence that the same factor has both favorable and unfavorable characteristics for health maintenance. Moreover, the clinical status of the participants might determine these characteristics, as in our previous study 20 , 21 . Therefore, this study provided new insights into mechanisms related to thyroid hormones.…”

Section: Discussionmentioning

confidence: 88%

Association between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study

Shimizu

Kawashiri

Noguchi

et al. 2021

Sci Rep

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Our recent studies indicate that thyroid cysts have clinical implications. Thyroid cysts could have a positive effect on the supply of thyroid hormones. Both hyperthyroidism and hypothyroidism cause hypertension. Hypothyroidism, but not hyperthyroidism, is a risk factor for atherosclerosis. Therefore, thyroid cysts could be associated with hypertension, and atherosclerosis might influence the association between thyroid cysts and hypertension. To evaluate the clinical significance of thyroid cysts, a cross-sectional study was conducted with 1801 Japanese aged 40–74 years. Thyroid cysts were significantly positively associated with hypertension in participants without atherosclerosis. However, there was a significant inverse association in those with atherosclerosis. The potential confounding factor adjusted odd ratios and 95% confidence intervals (95% CIs) were 1.49 (95% CI 1.17–1.90) for participants without atherosclerosis and 0.49 (95% CI 0.24–0.98) for those with atherosclerosis. The present study demonstrates that thyroid cysts have clinical implications because thyroid cysts support thyroid hormone activity. Our findings provide sufficient evidence to develop a risk assessment for hypertension for the general population, even though further research is required.

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Section: Discussionmentioning

confidence: 88%

Association between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study

Shimizu

Kawashiri

Noguchi

et al. 2021

Sci Rep

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Associations of Serum Insulin-Like Growth Factor 1 with New Cardiovascular Events and Subsequent Death in Hemodialysis Patients: The DREAM Cohort

Nakaya

Shoji

Nagata

et al. 2022

JAT

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Patients with chronic kidney disease (CKD) have elevated risk of death from cardiovascular disease (CVD).A low serum insulin-like growth factor 1 (IGF-1) level is known to predict higher risk for all-cause mortality in incident dialysis patients, although it is unknown whether IGF-1 predicts cardiovascular outcomes.Methods: This was a prospective cohort study of maintenance hemodialysis patients followed up for 5 years. Serum IGF-1 levels were measured at baseline, and patients were divided into IGF-1 tertiles. The key outcomes were all-cause mortality, a composite of new CVD, and death after new CVD events. Additional outcomes were hospitalization for infection and subsequent death. Association was analyzed using Cox proportional hazards models. Results:In the 516 patients that were analyzed, we identified 106 all-cause deaths, 190 new CVD events, and 61 subsequent deaths. In addition, there were 169 hospitalizations for infection and 47 subsequent deaths. The risk of all-cause death was the highest in the lowest IGF-1 tertile, and this association remained significant in multivariable-adjusted models. Regarding CVD outcomes, IGF-1 was not associated with new CVD events but significantly associated with subsequent death in adjusted models. Similarly, IGF-1 was not an independent predictor of hospitalization for infection, but it predicted subsequent death. Conclusions:A low IGF-1 level was not a significant predictor of new CVD events but an independent predictor of subsequent death in hemodialysis patients. Since similar associations with infection outcomes were observed, IGF-1 may be a biomarker of fragility or frailty in this population.(CVD) but also for death after CVD events 2) . These two factors synergistically increase the risk of cardiovascular death 3) .The elevated risk of CVD death in patients with chronic kidney disease (CKD), including those on hemodialysis, has been explained by the traditional and nontraditional risk factors 4) . Obesity is one of the Copyright©2021 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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Insulin-Like Growth Factor-1 (IGF-1) and Reduced Tongue Pressure in Relation to Atherosclerosis Among Community-Dwelling Elderly Japanese Men: A Cross-Sectional Study

Cited by 2 publications

References 22 publications

Association between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study

Association between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study

Associations of Serum Insulin-Like Growth Factor 1 with New Cardiovascular Events and Subsequent Death in Hemodialysis Patients: The DREAM Cohort

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