Platelets and Their Interactions with Other Immune Cells

Lam, Fong; Vijayan, K. Vinod; Rumbaut, Rolando E.

doi:10.1002/cphy.c140074

Cited by 122 publications

(126 citation statements)

References 235 publications

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“…β-lysin, which is one of the most abundant compound found in PL after activation 46 has been described to act against bacteria cell-wall, rapidly killing and stopping bacteria reproduction [44][45] , which could explain the results from this study. In addition, other PL-derived molecules with antibacterial properties against Gram+ bacteria could be involved in this response, such as neutrophil activating protein-2 demonstrated capacity to kill Gram-positive and Gram-negative bacteria [47][48] . Although no effect was observed against Gram-bacteria and fungus, other factors can be found in PL with bactericidal and fungicidal activity.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for Periodontal Endogenous Regenerative Technology

Babo

Pires

Santos

et al. 2017

ACS Biomater. Sci. Eng.

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The integrity and function of the periodontium can be compromised by traumatic injuries or periodontitis. Currently available clinical therapies are able to stop the progression of periodontitis and allow the healing of periodontal tissue. However an optimal strategy capable of restoring the anatomy and functionality of the lost periodontal tissue is still to be achieved. This injectable system is based on a photocrosslinkable hydrogel, prepared from methacrylated Hyaluronic Acid (me-HA) and incorporating Platelet Lysate (PL). The delivery of growth factors and cells in situ is expected to enhance regeneration of the periodontium. Various formulations of me-HA containing increasing PL concentrations were studied for achieving the formation of stable photocrosslinkable hydrogels. The produced hydrogels were subsequently characterized to assess mechanical properties, degradation, protein/growth factor release profile, antimicrobial activity and response towards human Periodontal Ligament fibroblasts (hPDLFs). The results demonstrated that it was possible to obtain stable photocrosslinkable hydrogels incorporating different amounts of PL that can be released in a sustained manner. Furthermore, the incorporation of PL improved (p<0.02) the viscoelastic properties of the hydrogels and enhanced their resilience to the degradation by hyaluronidase (HAase). Additionally, the PL showed to provide antimicrobial properties.Finally, hPDLFs, either seeded or encapsulated into the developed hydrogels, showed enhanced proliferation over time (p<0.05), proportionally to the increasing amounts of PL present in the hydrogel formulations.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for Periodontal Endogenous Regenerative Technology

Babo

Pires

Santos

et al. 2017

ACS Biomater. Sci. Eng.

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“…GPVI mediates platelet binding to collagen. Platelets express complement receptors, receptors for immunoglobins (FcR) and Toll-like receptors (Lam et al 2015).…”

Section: Hemostatic Activity Of Blood Plateletsmentioning

confidence: 99%

The physiology of blood platelets and changes of their biological activities in multiple sclerosis

Wachowicz¹,

Morel²,

Miller³

et al. 2016

Acta Neurobiologiae Experimentalis

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Increasing evidence indicates that blood platelets contribute to diverse processes that extend beyond hemostasis. Many of the same mechanisms that play a role in hemostasis and thrombosis facilitate platelets the participation in other physiological and pathological processes, particularly in the inflammation, the immune response and central nervous system disorders. Platelets are involved in pathophysiology of central nervous system diseases, especially in the pathogenesis of multiple sclerosis, but their role appears to be neglected. Platelets contribute to the inflammation and cooperate with immune cells in inflammatory and immune responses. These blood cells were identified in inflamed spinal cord and in the brain in chronic active lesions of multiple sclerosis and in the related animal models referred as Experimental Autoimmune Encephalomyelitis. This review summarizes recent insights in the platelet activation accompanied by the exocytosis of bioactive compounds stored in granules, formation of platelet microparticles, expression of specific membrane receptors, synthesis of numerous biomediators, generation of free radicals, and introduces the mechanisms by which activated platelets may be involved in the pathophysiology of multiple sclerosis. Understanding the role of platelets in multiple sclerosis may be essential for improved therapies.

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“…Increasing evidence supports the notion that platelets represent immune cells, mediating a variety of inflammatory and immune responses. 9 One possible mechanism by which platelets may contribute to APAP-induced liver injury is via their interactions with leukocytes in promoting inflammation, as occurs in various other models of sterile inflammation. 9 Alternatively, platelets contain a host of proinflammatory mediators, which conceivably may mediate their role in APAP-induced liver injury.…”

mentioning

confidence: 99%

“…9 One possible mechanism by which platelets may contribute to APAP-induced liver injury is via their interactions with leukocytes in promoting inflammation, as occurs in various other models of sterile inflammation. 9 Alternatively, platelets contain a host of proinflammatory mediators, which conceivably may mediate their role in APAP-induced liver injury. 9 Furthermore, as suggested by the authors, platelets may serve to amplify thrombin activity, possibly contributing to injury via microthrombus formation.…”

mentioning

confidence: 99%

“…9 Alternatively, platelets contain a host of proinflammatory mediators, which conceivably may mediate their role in APAP-induced liver injury. 9 Furthermore, as suggested by the authors, platelets may serve to amplify thrombin activity, possibly contributing to injury via microthrombus formation. Finally, the findings by Miyakawa et al, 1 in light of a recent report that NAC reduces the size of von Willebrand factor (VWF) multimers and platelet-VWF string formation on endothelial cells, 10 lead to the interesting speculation that the therapeutic effect of NAC in APAP overdose might be due in part to inhibition of platelet accumulation and subsequent plateletmediated liver injury.…”

mentioning

confidence: 99%

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