Platelets and circulating CD34-positive cells as an indicator of the activity of the vicious cycle between hypertension and endothelial dysfunction in elderly Japanese men

Shimizu, Yūji; Sato, Shimpei; Koyamatsu, Jun; Yamanashi, Hirotomo; Nagayoshi, Mako; Kadota, Koichiro; Kawashiri, S.-Y.; Inoue, Keita; Nagata, Yasunobu; Maeda, Takahiro

doi:10.1016/j.atherosclerosis.2017.02.016

Cited by 40 publications

(88 citation statements)

References 34 publications

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“…In addition, as in our previous study [2], we found no significant association between height and CIMT. Additional studies we conducted previously reported that a high level of platelets and a low level of circulating CD34-positive cells is an independent risk factor for the vicious cycle between hypertension and atherosclerosis, whereas high platelets and high CD34-positive cells are not since appropriate endothelial repair is established in these subjects [26]. In our present study, we found a significant positive association between platelets and circulating CD34-positive cells among subjects with high hemoglobin levels.…”

Section: Discussionsupporting

confidence: 74%

“…Since endothelial activity is closely associated with bone marrow activity [13,23], which is also strongly influenced by age-related decline [14,25], an analysis limited to subjects with high bone marrow activity (high hemoglobin) should strengthen the influence of endothelial repair. However, although both platelet and CD34-positive cell production are stimulated by endothelial injury, aggressive endothelial repair (the cause of atherosclerosis) may cause consumptive reduction of CD34-positive cells, but not platelets [26]. Therefore, in the present study, among subjects with high hemoglobin, although a significant positive association between platelets and CIMT was observed, there was no significant association between circulating CD34-positive cells and CIMT.…”

Section: Discussioncontrasting

confidence: 51%

“…And we also reported in previous study that the number of platelets and circulating CD34-positive cells acts as an indicator of the activity of the vicious cycle that exists between hypertension and endothelial dysfunction in elderly Japanese men [26]. Since a significant inverse association was observed between height and platelet count among elderly Japanese men in present study, those with short stature might also activates the vicious cycle that exists between hypertension and endothelial dysfunction much The mechanism below the dotted line is observed only for subjects without severe age-related bone marrow activity reduction (subjects with high Hb).…”

Section: Discussionmentioning

confidence: 99%

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Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a crosssectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.

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Section: Discussionsupporting

confidence: 74%

Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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2018

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“…An age-adjusted trend test was performed with a regression model for mean values, and a logistic regression model was used for proportion. Since the number of circulating CD34 cells should indicate the presence of underlying endothelial repair activity [6, 14–18] and 0.99 cells/μL was the median value of the circulating CD34-positive cells in our present study, this value was set as the cutoff point, as in our previous study [6]. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to determine the influence of HDL on hypertension, and subjects were stratified according to the level of circulating CD34-positive cells (high, low).…”

Section: Methodsmentioning

confidence: 99%

“…Another study reported an inverse correlation between the level of cognitive impairment and the number of circulating CD34-positive cells in patients with vascular-type cognitive impairment [15]. Therefore, subjects with a high level of CD34-positive cells should have elevated endothelial repair activity [6, 16–18]. Since endothelial repair activity should be stimulated by endothelial injury, subjects with a high level of CD34-positive cells should present with endothelial injury similar to participants with stable cardiovascular disease and acute coronary syndrome.…”

Section: Backgroundsmentioning

confidence: 99%

Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels

Shimizu

Sato²,

Koyamatsu

et al. 2017

J Physiol Anthropol

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BackgroundAlthough high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension.MethodsTo investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60–69 years who participated in general health checkup.ResultsHDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022.ConclusionsIndependent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells.

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