Plateletpheresis in the Era of Automation: Optimizing Donor Safety and Product Quality Using Modern Apheresis Instruments

Das, Sudipta Sekhar; Sen, Subrata K.; Zaman, Rafique Uz; Biswas, Rathindra Nath

doi:10.1007/s12288-020-01337-1

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…The vast majority (96% in 2020) of platelet concentrates (PLT) are collected by apheresis to yield single donor units (SDP) in the United States (US) 1 . Compared with PLT derived from whole blood, which are pooled, SDP result in fewer donor exposures and transfusion‐related adverse events 2 . Three platforms for apheresis PLT collections are currently in use in the US: the MCS® + 9000 (Haemonetics), the Trima Accel® 7 (Terumo), and the Amicus Cell Separator (Fresenius Kabi).…”

Section: Introductionmentioning

confidence: 99%

“…1 Compared with PLT derived from whole blood, which are pooled, SDP result in fewer donor exposures and transfusion-related adverse events. 2 Three platforms for apheresis PLT collections are currently in use in the US: the MCS ® + 9000 (Haemonetics), the Trima Accel ® 7 (Terumo), and the Amicus Cell Separator (Fresenius Kabi). However, comparative studies of platelet quality across platforms are uncommon and largely limited to collection performance or biochemical assessment alone, [3][4][5][6][7] with no analyses comparing functional differences across apheresis platforms.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of platelet quality and function across apheresis collection platforms

et al. 2023

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Background Platelet concentrates (PLT) can be manufactured using a combination of apheresis collection devices and suspension media (plasma or platelet additive solution (PAS)). It is unclear how platelet quality and hemostatic function differ across the current in‐use manufacturing methods in the United States. The objective of this study was therefore to compare baseline function of PLT collected using different apheresis collection platforms and storage media. Study Design and Methods PLT were collected at two sites with identical protocols (N = 5 per site, N = 10 total per group) on the MCS® + 9000 (Haemonetics; “MCS”), the Trima Accel® 7 (Terumo; “Trima”), and the Amicus Cell Separator (Fresenius Kabi, “Amicus”). MCS PLT were collected into plasma while Trima and Amicus PLT were collected into plasma or PAS (Trima into Isoplate and Amicus into InterSol; yielding groups “TP”, “TI” and “AP”, “AI”, respectively). PLT units were sampled 1 h after collection and assayed to compare cellular counts, biochemistry, and hemostatic function. Results Differences in biochemistry were most evident between plasma and PAS groups, as anticipated. MCS and TP had the highest clot strength as assessed by viscoelastometry. AI had the lowest thrombin generation capacity. Both TP and TI had the highest responses on platelet aggregometry. AI had the greatest number of microparticles. Discussion Platelet quality and function differ among collection platforms at baseline. MCS and Trima platelets overall appear to trend toward higher hemostatic function. Future investigations will assess how these differences change throughout storage, and if these in vitro measures are clinically relevant.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of platelet quality and function across apheresis collection platforms

et al. 2023

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“…Among the donor characteristics considered in the current study, we found that the donor’s predonation platelet count had a substantial impact on platelet yield. Previous studies by Das et al ,[ 11 ] Guerrero-Rivera et al ,[ 9 ] and Enein et al . [ 12 ] reported similar findings.…”

Section: Discussionmentioning

confidence: 99%

“…However, when compared between Amicus and Trima, there was no appreciable difference in this. According to Altuntas et al ,[ 15 ] COM.TEC processed considerably more median blood volume than Amicus to achieve a platelet yield of ≥3.3 × 10 11 /unit (3481 vs. 2850 ml; P < 0.001). However, Philip et al .…”

Section: Discussionmentioning

confidence: 99%

Effect of donor parameters and cell separators on yield of apheresis platelet and their impact on corrected count increment in aplastic anemia patients

Yadav,

Srivastava,

Das

et al. 2023

Asian J Transfus Sci

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BACKGROUND: The new cell separators make it simple to collect single donor platelets (SDP), although the platelet yield may vary depending on the cell separator used and donor-related clinical and laboratory variables. AIMS: This study aims to study the factors affecting SDP yield and corrected count increment (CCI). MATERIALS AND METHODS: This retrospective study was carried out at a tertiary care facility in northern India, over 4 years (May 2017–April 2020), data were retrieved and analyzed. STATISTICAL ANALYSIS: Categorical variables were presented as proportions, while continuous variables were presented as mean with standard deviation, P < 0.05 was considered significant. RESULTS: We found a positive correlation between predonation platelet count and yield ( r = 0.243, P = 0.000). No such significant correlation was found with Hb concentration ( r = 0.025, P = 0.720), age ( r = 0.016, P = 0.820), sex ( r = −0.038, P = 0.584), and weight ( r = −0.025, P = 0.714). Maximum platelet yield and minimum time were seen with Trima. Only 39.3% (33/84) meet the 24 h CCI. The majority of patients did not meet the desired CCI could be due to the patients’ clinical condition. On logistic regression, we found a significant association of 24 h CCI with product yield (odds ratio [OR] = 0.168, P = 0.015) and posttransfusion platelet count (OR = 0.454, P < 0.05). CONCLUSION: The only donor-related factor that influences yield is predonation platelet count, whereas 24 h CCI may depend on the clinical status of the patient and yield.

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Long-term stability of frozen platelet-rich plasma under −80 °C storage condition

Liu,

et al. 2024

Regenerative Therapy

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Plateletpheresis in the Era of Automation: Optimizing Donor Safety and Product Quality Using Modern Apheresis Instruments

Cited by 3 publications

References 35 publications

Comparison of platelet quality and function across apheresis collection platforms

Comparison of platelet quality and function across apheresis collection platforms

Effect of donor parameters and cell separators on yield of apheresis platelet and their impact on corrected count increment in aplastic anemia patients

Long-term stability of frozen platelet-rich plasma under −80 °C storage condition

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