BACKGROUND:
The new cell separators make it simple to collect single donor platelets (SDP), although the platelet yield may vary depending on the cell separator used and donor-related clinical and laboratory variables.
AIMS:
This study aims to study the factors affecting SDP yield and corrected count increment (CCI).
MATERIALS AND METHODS:
This retrospective study was carried out at a tertiary care facility in northern India, over 4 years (May 2017–April 2020), data were retrieved and analyzed.
STATISTICAL ANALYSIS:
Categorical variables were presented as proportions, while continuous variables were presented as mean with standard deviation,
P
< 0.05 was considered significant.
RESULTS:
We found a positive correlation between predonation platelet count and yield (
r
= 0.243,
P
= 0.000). No such significant correlation was found with Hb concentration (
r
= 0.025,
P
= 0.720), age (
r
= 0.016,
P
= 0.820), sex (
r
= −0.038,
P
= 0.584), and weight (
r
= −0.025,
P
= 0.714). Maximum platelet yield and minimum time were seen with Trima. Only 39.3% (33/84) meet the 24 h CCI. The majority of patients did not meet the desired CCI could be due to the patients’ clinical condition. On logistic regression, we found a significant association of 24 h CCI with product yield (odds ratio [OR] = 0.168,
P
= 0.015) and posttransfusion platelet count (OR = 0.454,
P
< 0.05).
CONCLUSION:
The only donor-related factor that influences yield is predonation platelet count, whereas 24 h CCI may depend on the clinical status of the patient and yield.