Platelet volume: Laboratory measurement and clinical application

Jackson, Sarah; Carter, J.M.

doi:10.1016/s0268-960x(05)80020-7

Cited by 223 publications

(183 citation statements)

References 74 publications

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“…Pre-analytical variables, such as the anticoagulant used, and the time between blood collection and measurement are known to significantly affect MPV measurements. Although EDTA is traditionally used and recommended for samples destined for blood counting it is well known that platelets collected into EDTA anticoagulants undergo time-dependent platelet swelling and activation [9]. It is therefore critical that in studies where EDTA is the anticoagulant the time delay between sampling and analysis is standardized in both the controls and test samples so that accurate comparisons can be made both within and between studies [10].…”

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confidence: 99%

Studies on Mean Platelet Volume (MPV) – New Editorial Policy

Harrison

Goodall

2016

Platelets

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In this issue we highlight a very topical and timely review by Noris and colleagues entitled "New roles for MPV measurement in clinical practice?" [1], and discuss our newly proposed editorial policy for the minimum requirements for future manuscripts that include MPV measurement as their major focus.Fast, precise and reliable measurement of platelet number and size was revolutionized in the 1970s by the widespread availability of automated full blood counters that utilise the aperture impedance or "Coulter" principle that was invented 20 years earlier [2]. As a consequence MPV became an additional parameter of interest to both clinicians and researchers and is routinely available on most modern analysers. One of the fascinating aspects of the normal platelet volume distribution is the classical log-normal distribution demonstrating the heterogeneity of platelet size [3]. This also led to the discovery of the inverse relationship between platelet count and MPV that seems to maintain a remarkably tight control on the total platelet mass between individuals. Having defined normality it soon then became apparent that changes in MPV are associated with both acquired and inherited forms of thrombocytopenia. Noris et al discuss how abnormalities in platelet size using MPV are indeed useful for studying and differentiating between inherited forms of macrothrombocytopenia and giant platelet syndromes from other inherited conditions, and from acquired thrombocytopenias [1,4].However, as they point out, the majority of manuscripts on MPV (1313 papers in Pubmed since 2013; 98 papers which have appeared in this journal since 2006) have focused on the association of MPV with many other clinical conditions such as ischaemic and thrombotic disorders, and their associated clinical outcomes [1]. Many studies have now shown that MPV is raised in patients with thrombosis and can often predict poor outcomes. Norris et al have highlighted a number of important questions. Firstly they question whether a raised MPV is the possible cause of thrombosis or a consequence of the condition, for while there is sound evidence that MPV is influenced by genetic polymorphisms [5], and lifestyle factors [6], these effects account for <20% of natural variation [5,6,7], MPV is also increased following platelet consumption and acceleration of platelet turnover in thrombotic conditions. Noris et al emphasize that the majority of studies were performed during the acute phase of thrombosis which makes these mechanisms highly credible. We would also add that inflammatory mediators, such as IL-6, that are often raised in acute or chronic conditions, may also feedback to the bone marrow, resulting in changes to the whole Megakaryocytic/Platelet axis, polyploidization and consequent thrombopoiesis with a shift towards a more prothrombotic phenotype and a higher MPV [8].Despite these caveats, Noris et al have highlighted a number of population studies that indeed suggest a potential association between MPV and disease. An editorial by Lippi has also recentl...

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confidence: 99%

Studies on Mean Platelet Volume (MPV) – New Editorial Policy

Harrison

Goodall

2016

Platelets

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“…MPV values do not change over time when citrate is used as the anticoagulant. MPV values change by 3% within 3 h at 37°C temperature, whereas it increases by 20% at room temperature (23). Considering MPV measurements in previous studies have been conducted with This study had several limitations.…”

Section: Discussionmentioning

confidence: 92%

“…The shape and ultrastructure of platelets vary depending on the medium temperature and the method used (23). Furthermore, platelets in the blood collected in EDTA-coated tubes take the shape of a sphere, whereas those in the blood collected in citrate-coated tubes take the shape of a discoid.…”

Section: Discussionmentioning

confidence: 99%

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Effect of CPAP Treatment on Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) in Patients With Sleep Apnea Syndrome

Çörtük¹,

Şimşek²,

Kiraz³

et al. 2016

Eurasian J Pulmonol

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Objective: Obstructive sleep apnea (OSA) syndrome is a common disorder that can cause hypercoagulation. Mean platelet volume (MPV) and platelet distribution width (PDW) are associated with hypercoagulability. This study aimed to investigate whether MPV and PDW values change in patients with OSA who were treated with continuous positive airway pressure (CPAP) device.Methods: A total of 43 adult patients with OSA who were treated with CPAP were included in this retrospective study. Patients who underwent CPAP treatment for <5 days/week and <4 h/day were excluded. Blood parameters, including MPV and PDW, were recorded before CPAP treatment and at the third month of CPAP treatment. All patients underwent polysomnographic evaluation with full night polysomnography and in the second night CPAP titration was performed together with full night polysomnography and MPV and PDW values were statistically compared before and after CPAP treatment.Results: Apnea hypopnea index was significantly reduced, whereas oxygen saturation was significantly increased at CPAP titration night (p<0.001). The third month of CPAP treatment resulted in significantly low PDW (p=0.004) values, but MPV values did not change. Conclusion:PDW value at the third month of CPAP treatment revealed a significant improvement compared with the values before treatment; moreover, no change was observed in MPV values. It was concluded that in patients with OSA who were treated with CPAP, activation of platelets may result in recovery.

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“…[15] Thus, it is largely accepted that MPV is an independent risk factor for the first [16] and recurrent MI. [17] Although 3 major parameters have been postulated as determinants of platelet volume, including age dependent processes that can modify platelet size in the circulation, heterogeneity and maturity of the bone marrow megakaryocyte population, and peripheral size related sequestration of platelets in storage pools, [18] there is evidence that MPV is largely determined at or before the time of megakaryocyte fragmentation into platelets. [19] On the other hand, several previous studies revealed that mean MPV was larger in arterial and venous thrombosis and predicted a poor clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

et al. 2012

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ÖZET Amaç Bu retrospektif çalışmanın amacı, ortalama tombosit hacmini, akut derin ven trombozlu (DVT) hastalarda ve kontrol grubunda karşılaş-tırmaktır. Gereç ve Yöntem SUMMARY ObjectivesThe purpose of this retrospective study was to compare the mean platelet volume between the patients with acute deep vein thrombosis (DVT) and control subjects. MethodsData were collected retrospectively from the patients' medical records. The study group consisted of 110 patients with newly diagnosed acute DVT in the lower extremities. An age, gender, and body mass index-matched control group consisted of 98 patients with normal duplex ultrasound findings. We compared the mean platelet volume in patients with acute DVT and control participants. ResultsThere was no significant difference between the study and control groups in mean platelet volume (8.8±1.6 vs 8.7±1.3 fl, respectively; p>0.05). Age (p=0.899), body mass index (p=0.43), gender (p=0.466), and platelet count (p=0.886) were statistically similar in both groups. ConclusionsThere was no significant difference in mean platelet volume between patients with acute DVT and the control group. According to our result, we propose that mean platelet volume should not be considered as an index of acute DVT.

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Platelet volume: Laboratory measurement and clinical application

Cited by 223 publications

References 74 publications

Studies on Mean Platelet Volume (MPV) – New Editorial Policy

Studies on Mean Platelet Volume (MPV) – New Editorial Policy

Effect of CPAP Treatment on Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) in Patients With Sleep Apnea Syndrome

Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

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