Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario

Khandekar, Medha; Khurana, Abhas; Deshmukh, Sanjay D; Kakrani, Arjun; Katdare, A D; Inamdar, Avinash

doi:10.1136/jcp.2004.025387

Cited by 216 publications

(234 citation statements)

References 15 publications

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“…Compared to healthy controls, P-LCR is higher in patients with acute myocardial infarction and unstable angina [12,13]. None of the published studies correlating platelet indices with CAD and especially with STEMI present data on the associations between CTO and P-LCR.…”

Section: Platelet Indices and Ctomentioning

confidence: 73%

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Hadadi

Șuș

Lakatos

et al. 2015

Revista Romana De Medicina De Laborator

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Coronary chronic total occlusion (CTO) is caused by organized thrombi or atherosclerotic plaque progression. The presence of a CTO is an independent predictor of mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI). Platelets have a crucial role in the pathophysiology of atherosclerosis. The aim of this retrospective study was to investigate platelet indices as predictors of CTO in patients with STEMI treated with primary percutaneous coronary intervention (pPCI). A total number of 334 patients admitted for STEMI between January 2011 and December 2013 were included and divided in two groups based on the presence of CTO (48 patients in CTO+ group, 286 patients in CTO-group). Platelet count, mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio (P-LCR), lymphocyte and neutrophil count determined on admission were analyzed. MPV was larger in patients with CTO compared with patients without CTO (p=0.02), as were PDW (p=0.03) and P-LCR (p=0.01). Platelet-to-lymphocyte ratio (PLT/LYM) was lower in patients with

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Section: Platelet Indices and Ctomentioning

confidence: 73%

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Hadadi

Șuș

Lakatos

et al. 2015

Revista Romana De Medicina De Laborator

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“…PCT denotes the term for the percentage of blood volume occupied within the thrombocytes (20). Surfaces of cells are required for clotting alterations taking place, therefore the present authors examined PCT, as was also reported (17).…”

Section: Discussionmentioning

confidence: 99%

Thrombocyte indices in dogs infected with Ehrlichia canis and Anaplasma phagocytophilum

Özata

Ural

2014

Rev MVZ Córdoba

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Objectives. In the present study alterations in trombocyte numbers and trombocyte indices were investigated in 51 dogs naturally infected with E. canis and/or A. phagocytophilum. Achieved results were compared to those of 20 healty dogs comprising control group. Materials and methods. Naturally occuring vector borne diseases were diagnosed by use of a canine point-of-care ELISA kit (Snap 4Dx, Idexx). Dogs were enrolled into 3 groups as follows; II. group involved A. phagocytophilum infected dogs (n=10), III. group (n=13) E. canis+ A. phagocytophilum co-infected, and IV. group (n=28) E. canis infected dogs. Healthy controls (n=20) were enrolled in group I. Results. Mean PLT counts were significantly decreased in II., III. and IV. groups (159.6±63.5, 142.3±44.3, 148.7±33.5, respectively) in comparison to control group (370.4±28.6) (p≤0.01). Mean PCT values in groups II., III. and IV. (0.1530±0.590, 0.1531±0.0441, 0.1450±0.314, respectively) were significantly decreased in contrast to control group (0.3695±0.0283) (p≤0.01). Between PLT and PCT values, statistically significant positive correlation (p≤0.01) (r=0.988, 0.990 and 0.981, respectively) was evident among groups II., III. and IV. Conclusions. Infected dogs showed significant alterations (p≤0.01) among mean PLT and PCT values and a positive correlation was evident between those 2 parameters (p≤0.01), whereas alterations on mean MPV and PDWc were not statistically significant. Finally it was suggested that according to the aforimentioned results, PLT and PCT values may be used as valuable parameters for diagnosis and probably for monitorization and prognosis in infected dogs with Ehrlichiosis and/or Anaplasmosis. Key words: Anaplasma phagocytophilum, Ehrlichia canis,indices, thrombocyte (Source: CAB). RESUMENObjetivos. Comparar las alteraciones en el número de trombocitos y en los índices de trombocitos en perros infectados naturalmente con E. canis y A. phagocytophilum. Materiales y métodos. Los perros fueron distribuidos en cuatro grupos: Grupo I; perros sanos (n=20), Grupo II; perros infectados con A. phagocytophilum (n=10), Grupo III; perros infectados con E. canis + A. phagocytophilum (n=13) y grupo IV; perros infectados con E. Canis (n=28). Resultados. Los recuentos de PLT se redujeron significativamente (p≤0.01) en los grupos II, III y IV (159.6±63.5, 142.3±44.3, 148.7±33.5, respectivamente) en comparación con el grupo control (370.4±28.6). La media de los valores de PCT en los grupos II, III y IV fue de 0.1530±0.590, 0.1531±0.0441 y 0.1450±0.314 respectivamente, cuyas reducciones fueron significativas (p≤0.01) en contraste con el grupo control (0.3695±0.0283). Entre los valores de PLT y el PCT la correlación fue positiva (r =0. mostraron alteraciones significativas (p≤0.01) entre PLT y los valores del PCT, así como una correlación positiva entre esos dos parámetros (p≤0.01), mientras que las alteraciones de MPV y PDWc no fueron significativas. Se sugiere que de acuerdo con los resultados obtenidos, los valores de PLT y el PCT se pueden utiliz...

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“…12,13 Previous studies disclosed that MPV was linked with coronary artery disease, myocardial infarction, peripheral artery disease, and cerebral ischemia. [5][6][7][8] Several studies have showed that there were aggregates of thyrombocytes in retinal capillaries of diabetic rats. 14, 15 Tuzcu et al 9 conducted an experiment with 192 patients and showed a correlation between MPV levels and DR.…”

Section: Resultsmentioning

confidence: 99%

“…4 Mean platelet volume (MPV) reflects the average size of platelets present in a person's blood sample. 5 It is a marker indicating subclinical platelet activation and is an independent risk factor for various vascular episodes such as acute myocardial infarction, 5 coronary artery disease, 6 cerebral ischemia, 7 and peripheral artery disease. 8 There are limited reports in literature showing relation between DR and platelet indices.…”

Section: Introductionmentioning

confidence: 99%

MPV may reflect subcinical platelet activation in diabetic patients with and without diabetic retinopathy

Çıtırık

Beyazyıldız

Şimşek

et al. 2014

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Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario

Cited by 216 publications

References 15 publications

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Thrombocyte indices in dogs infected with Ehrlichia canis and Anaplasma phagocytophilum

MPV may reflect subcinical platelet activation in diabetic patients with and without diabetic retinopathy

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