Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study

Abstract

BackgroundPlatelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been reported to reflect the inflammatory response and disease activity in a variety of autoimmune diseases.ObjectivesThis study aimed to evaluate the value of PLR and NLR as markers to monitor disease activity in Takayasu’s arteritis (TAK).MethodsA retrospective case–control study involving 88 patients with TAK and 78 healthy controls was performed. We compared the PLR and NLR between patients and healthy controls, and also analysed the correlations between PLR or NLR and indices of TAK disease activity.ResultsIncreased PLR and NLR were observed in patients with TAK. PLR was positively correlated with hs-C-reactive protein (hs-CRP) (r=0.239, p=0.010) and erythrocyte sedimentation rate (ESR) (r=0.270, p=0.010). NLR also exhibited a positive relationship with Kerr’s score (r=0.284, p=0.002), hs-CRP (r=0.313, p=0.006) and ESR (r=0.249, p=0.019). A PLR level of 183.39 was shown to be the predictive cut-off value for TAK (sensitivity 37.8%, specificity 93.0%, area under the curve (AUC)=0.691). A NLR level of 2.417 was found to be the predictive cut-off value for TAK (sensitivity 75.6%, specificity 55.8%, AUC=0.697).ConclusionsPLR and NLR could be useful markers to reflect inflammation and disease activity in patients with TAK.

Takayasu Arteritis

“…Pentraxin3 (PTX-3) serum levels have been reported to be associated with active disease ( 132 , 133 ). Also, platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been reported to reflect the inflammatory phases of the disease ( 134 ). These findings still require confirmatory studies in clinical settings.…”

Prognostic Value of Neutrophil-To-Lymphocyte Ratio and Platelet-To-Lymphocyte Ratio for Renal Outcomes in Patients with Rapidly Progressive Glomerulonephritis

“…In recent years, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have received attention as potential new markers of systemic inflammation. In previous studies, NLR and PLR have been reported to be useful in systemic inflammatory diseases such as aortitis syndrome [6], Behçet's disease [7], Kawasaki disease [8], Henoch-Schönlein purpura [9], systemic lupus erythematosus [10], and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) [11,12]. Furthermore, NLR and PLR have been proposed as markers of inflammation in patients with ESRD [13,14].…”

Neutrophil-to-Lymphocyte Ratio Is an Independent Predictor of 30-Day Mortality of Intracerebral Hemorrhage Patients: a Validation Cohort Study

“…Neutrophil-to-lymphocyte ratio (NLR) increases with increasing severity of inflammatory response and has been associated with poor patient outcomes in cancers (Grenader et al 2016 ; Ojerholm et al 2017 ), cardiovascular diseases (Kurtul et al 2016 ; Sari et al 2015 ), ischemic diseases (Aktimur et al 2016 ; Qun et al 2017 ), and a variety of other conditions (Ozcicek et al 2017 ; Pan et al 2017 ; Senturk et al 2016 ). A recent study from this research group (Wang et al 2016 ) showed an association of high NLR with 30-day mortality in ICH patients.…”