Platelet Survival in Patients with Diabetes Mellitus

Abstract

Platelet survival by 51chromium labeling was determined in six normal control subjects and in twelve patients with diabetes mellitus, before and after improved glucose control (mean HbA1c 10.5 +/- 2.2% and 7.1 +/- 1.8%, respectively). Mean platelet survival was 9.47 +/- 0.85 days for the normal subjects and 9.04 +/- 1.40 and 9.90 +/- 1.05 for the diabetic subjects in hyperglycemic and improved glycemic states, respectively. The differences between these values were not statistically significant. However, platelet survivals performed in three diabetic patients who had severe retinal disease requiring photocoagulation were significantly shortened compared with nonsmoking control subjects (P less than 0.05) or to patients without severe retinopathy (P less than 0.01). These observations imply that measurable changes in in vivo platelet survival occur after the development of small vessel disease. It remains to be determined whether abnormalities described for diabetic platelets in vitro or changes in in vivo platelet physiology contribute to the initiation or propagation of vascular disease in the hyperglycemic individual.

Clustered components of the metabolic syndrome and platelet counts in Japanese females

“…Our results may expand on earlier findings on asso- ciations between PCs and MS (5) or insulin resistance (4). A few studies have suggested that a shorter platelet lifespan in patients with diabetes mellitus and atherosclerosis leads to increased PCs through a more active platelet production mechanism (24)(25)(26). In general, peripheral PCs depend on several complex factors (e.g., platelet survival, platelet production rate, and the exchangeable splenic platelet pool) (23).…”

The association between platelet count and metabolic syndrome in children and adolescents

“…Third, the biological plausibility of this association between platelet count and MetS may depend on insulin resistance. Platelet lifespan is known to be shorter in patients with insulin resistance [25]. Circulating TPO level involved in hyperglycemia, hyperinsulinemia, and insulin resistance, resulting enhanced platelet activation [26].…”

Platelet Enzyme Activities in Diabetes Mellitus in Relation to Endothelial Damage

“…910 ' 2830 - 32 In addition, we and others have found a shortened life span of platelets in patients with Rd, again suggesting an increased turnover of platelets. 101433 " 35 Surprisingly, not only the "aggregatory pathways" of plate-lets seemed to be more active in relation to Rd, but also the anti-or disaggregatory system of prostacyclin-stimulated adenylate cyclase. There was a close correlation of ADPinduced platelet aggregation in vitro with prostacyclin-stimulated adenylate cyclase activity of platelets.…”