Platelet Surface CD62p and Serum Vitamin D Levels are Associated with Clopidogrel Resistance in Chinese Patients with Ischemic Stroke

Lu, Bichao; Shi, Xiao-Jie; Lin, Liang; Dong, Na; Liu, Zhizhong

doi:10.1016/j.jstrokecerebrovasdis.2019.01.031

Cited by 15 publications

(12 citation statements)

References 35 publications

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“…The authors reported an inadequate inhibition of adenosine-di-phosphate (ADP)-mediated platelet aggregation by clopidogrel and ticagrelor in patients with lower vitamin D levels. More recently, Lu et al [ 89 ] also showed that, in patients with ischemic stroke, clopidogrel resistance, defined according to the platelet maximum aggregation rate induced by ADP, is associated with significantly lower vitamin D levels than those measured in clopidogrel-sensitive patients. To date, the exact mechanism linking vitamin D to ADP-mediated platelet aggregation is not yet known.…”

Section: Vitamin D and Interaction With Antiplatelet Drugsmentioning

confidence: 99%

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

et al. 2021

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Vitamin D deficiency is a prevalent condition, occurring in about 30–50% of the population, observed across all ethnicities and among all age groups. Besides the established role of vitamin D in calcium homeostasis, its deficiency is emerging as a new risk factor for cardiovascular disease (CVD). In particular, several epidemiological and clinical studies have reported a close association between low vitamin D levels and major CVDs, such as coronary artery disease, heart failure, and atrial fibrillation. Moreover, in all these clinical settings, vitamin deficiency seems to predispose to increased morbidity, mortality, and recurrent cardiovascular events. Despite this growing evidence, interventional trials with supplementation of vitamin D in patients at risk of or with established CVD are still controversial. In this review, we aimed to summarize the currently available evidence supporting the link between vitamin D deficiency and major CVDs in terms of its prevalence, clinical relevance, prognostic impact, and potential therapeutic implications.

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Section: Vitamin D and Interaction With Antiplatelet Drugsmentioning

confidence: 99%

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

et al. 2021

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“…7 Previously, few studies investigated direct associations between vitamin D concentrations and platelet parameters in health and disease. [35][36][37][38][39][40] Verdoia et al reported an association between low vitamin D concentrations and high-residual platelet reactivity in patients with cardiovascular diseases receiving dual antiplatelet therapy, 35 and similarly this was shown in patients with diabetes. 38 Moreover, in hemodialysis patients vitamin D supplementation resulted in antithrombotic effects.…”

Section: Discussionmentioning

confidence: 77%

Platelet Integrin αIIbβ3 Activation is Associated with 25-Hydroxyvitamin D Concentrations in Healthy Adults

et al. 2020

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Background Cardiovascular events are associated with low circulating vitamin D concentrations, although the underlying mechanisms are poorly understood. This study investigated associations between 25-hydroxyvitamin D concentrations, platelet function, and single-nucleotide polymorphisms (SNPs) in genes influencing vitamin D biology in the 500 Functional Genomics (500FG) cohort. Methods In this observational study, platelet activation and function were measured by flow cytometry by binding of fibrinogen to the activated fibrinogen receptor integrin αIIbβ3 and expression of P-selectin, markers of platelet aggregation and degranulation, respectively. These parameters were correlated to serum 25-hydroxyvitamin D and genotyping was performed to investigate SNPs in genes important for vitamin D biology. Results Circulating 25-hydroxyvitamin D concentrations correlated inversely with baseline platelet binding of fibrinogen to integrin αIIbβ3 (Pearson's r= –0.172, p = 0.002) and platelet responses to platelet agonist cross-linked collagen-related peptide (CRP-XL) (Pearson's r= –0.196,p = 0.002). This effect was due to circulating vitamin D levels ≤50nmol/L, since no differences in platelet fibrinogen binding were observed between subjects with normal 25-hydroxyvitamin D concentrations (>75nmol/L) and a 25-hydroxyvitamin D insufficiency (50–75 nmol/L). No correlations between 25-hydroxyvitamin D concentrations and platelet P-selectin expression were found. Several SNPs in the GC region of the vitamin D binding proteingene were associated with platelet responses to CRP-XL. Conclusion Low circulating vitamin D concentrations are associated with increased platelet fibrinogen binding to integrin αIIbβ3 in unstimulated samples and after stimulation with CRP-XL. These findings may contribute to the increased incidence of cardiovascular events in vitamin D deficient adults and its seasonal variation. Further studies are needed to investigate causality.

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“…The relationship between low vitamin D concentrations and reduced drug efficacy or resistance, as discussed in the medical world, may also have an impact on the presented results. Studies reported insufficient inhibition of thrombocyte aggregation by clopidogrel and ticagrelor in patients with lower vitamin D levels [54] or even clopidogrel resistance [59]. A significant association has also been demonstrated between severe vitamin D deficiency and higher platelet reactivity in diabetic patients receiving dual antiplatelet therapy (aspirin and clopidogrel or ticagrelor or prasugrel) [60].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity

Dziedzic

Gąsior

Sowińska

et al. 2022

JCM

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Coronary artery disease continues to be the leading cause of death in developed countries. Elevated mean platelet volume (MPV) is associated with an increased incidence of myocardial infarction (MI) and MI-related mortality. Vitamin D concentrations affect the level and function of platelets, which are the crucial mediator of atherothrombosis and plaque rupture. The main aim of this study was to examine the relationship of serum 25-hydroxyvitamin D (25(OH)D) levels with the platelet activity in patients with a history of an acute coronary syndrome (ACS). This prospective study recruited 268 patients with a history of MI who underwent coronary angiography due to the suspicion of another ACS. Serum 25(OH)D concentration was determined by electrochemiluminescence. Platelet activity was assessed using the MPV and platelet-large cell ratio (P-LCR) parameters. There was no significant difference in MPV and P-LCR values between patients diagnosed with subsequent MI and patients with chronic coronary syndrome (CCS). A significantly lower level of 25(OH)D was demonstrated in patients who had another MI compared to those with CCS (p < 0.05). No significant correlation of 25(OH)D concentrations with platelet activity parameters values was found. The subgroup of patients with consecutive MI was characterized by significantly lower serum vitamin D levels, but this was not related to the analyzed parameters of platelet activity.

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Platelet Surface CD62p and Serum Vitamin D Levels are Associated with Clopidogrel Resistance in Chinese Patients with Ischemic Stroke

Cited by 15 publications

References 35 publications

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

Platelet Integrin αIIbβ3 Activation is Associated with 25-Hydroxyvitamin D Concentrations in Healthy Adults

Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity

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