“…In general, the quantification of platelet abnormalities can be performed using a wide variety of measures, such as platelet volume, aggregometry (Gabassov et al, 1989), excretion of metabolites (FitzGerald et al, 1988), flow cytometry (Corash, 1990) to detect various platelet antigens, and by the measurement of increased plasma levels of platelet products, such as platelet factor 4, beta thromboglobulin (Chen &Wu, 1980;Ikeda et al,1997) , the soluble adhesion molecule P-selectin (Blann et al, 1997),soluble CD40L (Choudhury et al,2007) and matrix metalloproteinase-1 (Martin et al,2003) (Table 2). However, some measures (such as platelet volume) are less useful or practical.…”