Atrial fibrillation and platelet reactivity

Milovanovic, Micha; Fransson, Elisabeth; Hallert, Claes; Järemo, Petter

doi:10.1016/j.ijcard.2010.02.030

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…Notably, AA, enriched in the HTN-AF group, interacted with other differential fatty acids and contributed to multiple inflammatory and pathogenic pathways, including Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, aldosterone synthesis and secretion, platelet activation, ferroptosis, and necroptosis, etc. [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation

Chen

Zuo

et al. 2022

Biomolecules

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Disordered gut microbiota (GM) as the co-contributor of atrial fibrillation (AF) and hypertension (HTN) might be associated with AF risk in HTN. This study aimed to explore the altered GM community and metabolic patterns between 27 HTN patients with AF (HTN-AF) and 27 non-AF HTN patients through fecal metagenomic and serum metabolomic analysis. Compared to non-AF HTN patients, significant microbial alterations (p = 0.004), including increased microbial diversity (p < 0.05), shifted enterotype dominated by Prevotella to Bacteroides, and abundant disease-linked genera Ruminococcus, Streptococcus, Veillonella, Dorea, and Enterococcus, were observed in HTN-AF patients. A species-based random forest prediction model was associated with the risk of AF occurrence in HTN patients. Furthermore, GM metabolic profiles dramatically differed between HTN and HTN-AF patients, especially the imbalance of saturated and unsaturated fatty acids. In HTN-AF patients, circulating palmitic acid and arachidonic acid levels were significantly elevated, while the levels of tetracosahexaenoic acid, oleic acid, linoleic acid, and stearic acid were decreased (p < 0.001, VIP > 1), mediating 85.99% of gut microbial indirect effects on AF (p < 0.001). Thus, our findings preliminarily indicated that exacerbated dysbiosis of GM and relevant metabolites was associated with high AF susceptibility and might be a potential target for AF prediction and prevention in HTN.

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Section: Resultsmentioning

confidence: 99%

Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation

Chen

Zuo

et al. 2022

Biomolecules

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“…Different platelet reactivity was found in patients with and without AF 16. Therefore, receiver operating characteristic curve analyses were performed after stratifying the patient population by occurrence of AF.…”

Section: Resultsmentioning

confidence: 99%

“…Different platelet reactivity was found in patients with and without AF. 16 Therefore, receiver operating characteristic curve analyses were performed after stratifying the patient population by occurrence of AF. In patients without AF, the AUC was 0.708 (95% confidence interval [CI], 0.672-0.743; P<0.001; Table 2 and Figure 2A) for platelet counts as predictors of in-hospital all-cause mortality.…”

Section: Thrombocytopenia and In-hospital Deathmentioning

confidence: 99%

Thrombocytopenia as a Preoperative Risk Assessment Tool in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Surgery

Wei

Jiang

Liu

et al. 2017

JAHA

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BackgroundPostoperative thrombocytopenia has been reported to be correlated with adverse events, but the prognostic value of baseline thrombocytopenia is unclear. This study was undertaken to evaluate the relationship between preoperative thrombocytopenia and adverse outcomes in patients with rheumatic heart disease who underwent valve replacement surgery.Methods and ResultsA total of 1789 patients with rheumatic heart disease undergoing valve replacement surgery were consecutively enrolled and postoperatively followed up for 1 year. Patients were stratified on the basis of presence (n=495) or absence (n=1294) of thrombocytopenia (platelet count, <150×109/L), according to hospital admission platelet counts. During the hospitalization period, 69 patients (3.9%) died. The in‐hospital all‐cause mortality rate was significantly higher in the thrombocytopenic group (6.9% versus 2.7%; P<0.001). Multivariate analyses revealed that thrombocytopenia was independently associated with in‐hospital all‐cause mortality (odds ratio, 2.21; 95% confidence interval, 1.29–3.80; P=0.004). Platelet counts could predict in‐hospital all‐cause mortality for patients both with and without previous atrial fibrillation (areas under the curve, 0.708 [P<0.001] and 0.610 [P=0.025], respectively). One‐year survival was significantly lower in patients with thrombocytopenia compared with controls (91.3% versus 96.1%; log‐rank=14.65; P<0.001). In addition, thrombocytopenia was an independent predictor for postoperative 1‐year all‐cause mortality in multivariate Cox regression analysis.ConclusionsPlatelet counts, as simple and inexpensive indexes, were reliable to be used as a preoperative risk assessment tool for patients with rheumatic heart disease undergoing valve replacement surgery.

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“…Both surface-bound P-selectin and fibrinogen were determined using a Beckman Coulter EPICS XL-MCL flow cytometer (Beckman Coulter Inc., Brea, CA, USA). Previous communications from our laboratory describe the procedures in detail [13,14]. In brief, a phycoerythrinconjugated monoclonal antibody against glycoprotein Ib (Dako AS, Denmark) recognized platelets.…”

Section: Analytical Proceduresmentioning

confidence: 99%

“…Frequently, surface expression of P-selectin and fibrinogen following stimulation, as determined by flow cytometry, is used as a platelet reactivity measure [12,13]. The latter determination reflects activated glycoprotein IIb/IIIa [14]. Surface-bound P-selectin in vivo is a sign of platelet activation and -granule release.…”

Section: Introductionmentioning

confidence: 99%

Platelets and acute cerebral infarction

et al. 2012

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Stroke is worldwide a leading cause of death and disability. Its etiology is regarded as heterogeneous. Platelets are implicated in its pathophysiology, but our understanding of their specific role is incomplete. Only sparse and conflicting information exists about platelet reactivity and activity in acute stroke. Some scientists take the view that platelets activate in conjunction with acute cerebral infarctions. Others put forward evidence corroborating the contrary notion. Increased soluble P-selectin as a sign of platelet and/or endothelial activity seems to be a feature of the disease. The latter point of view is opposed by other researchers. Due to these conflicting opinions, this study is devoted to platelet characteristics in acute cerebral infarctions. We studied subjects (n ¼ 72; age 74 AE 10(SD) years; 31 females) having acute stroke. As controls served atrial fibrillation (AF) patients (n ¼ 58; age 69 AE 7(SD) years; 12 females) subject to electrical cardioversion, a flow cytometer was put to use for measuring platelet reactivity and activity. After agonist provocation, both platelet bound P-selectin and fibrinogen were employed as estimates of platelet reactivity. Dilutions of a thrombin-receptor-activating peptide (TRAP-6) (74 and 57 mmol/l) (P-selectin and fibrinogen) and ADP (8.5 and 1.7 mmol/l) (fibrinogen only) were put to use as platelet agonists. Membrane-bound P-selectin without agonist stimulation served as a measure of in vivo platelet activation. Soluble P-selectin, as determined from a commercial ELISA, was used to assess platelet and/or endothelial activity. In acute stroke neither platelet-bound P-selectin nor fibrinogen after stimulation, i.e. reactivity, differed from AF controls. In contrast, lower platelet activity as judged from surface attached and circulating P-selectin without agonist stimulation proved to be a feature of cerebral infarctions. The p-values were p < 0.001 and p < 0.01, respectively. It is concluded that acute stroke is not associated with platelet reactivity platelets circulate less activated during the disease. It is evident that the mechanisms reflecting platelet reactivity and activity being investigated in this study play minor roles in stroke pathophysiology. New powerful platelet inhibitory drugs are currently introduced. To avoid major bleeding studies on platelet, behavior in acute stroke are necessary before including these medications in stroke treatment protocols.

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Atrial fibrillation and platelet reactivity

Cited by 7 publications

References 9 publications

Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation

Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation

Thrombocytopenia as a Preoperative Risk Assessment Tool in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Surgery

Platelets and acute cerebral infarction

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