Platelet serotonin in subtypes of schizophrenia and unipolar depression

Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms

“…This finding agrees with the association between platelet 5-HT content and aggression (Goveas et al, 2004), impulsivity and violence (Askenazy et al, 2000), psychotic symptoms of depression (Muck-Seler et al, 1996a;Pivac et al, 1997a), delusions in dementia (Meszaros et al, 1998), positive (Pivac et al, 1997b) or paranoid (Muck-Seler et al, 1991) symptoms of schizophrenia, supporting the hypothesis that platelet 5-HT concentration is related to trait markers (Askenazy et al, 2000;Peirson et al, 1999), such as psychotic symptoms in PTSD (present study). Our data suggest that platelet 5-HT may distinguish between PTSD subjects with and without psychotic symptoms.…”

Platelet serotonin and serum lipids in psychotic mania

“…In agreement with the increased platelet 5-HT concentration in other psychiatric disorders with psychotic features (Stahl et al, 1983;Muck-Seler et al, 1988;Muck-Seler et al, 1991;Muck-Seler et al, 1996;Meszaros et al, 1998;Pivac et al, 2006a), the major 7 finding of our study is a different platelet 5-HT concentration between psychotic and nonpsychotic subtypes of mania. Platelet 5-HT concentration is the result of a dynamic balance between its synthesis and uptake by platelets and breakdown by MAO.…”

The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men

“…Platelet MAO-B activity is under influence of sex, and sex differences are found in platelet MAO-B activity, with higher values of platelet MAO-B in female than in male subjects (Muck-Seler et al, 1991;Verkes et al, 1998;Snell et al, 2002;Oreland, 2004;Coccini et al, 2005;Pivac et al, 2005). (Oreland, 2004), that have been shown to increase platelet MAO-B activity.…”