The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men

Pivac, Nela; Knežević, Jelena; Mustapić, Maja; Deželjin, Martina; Mück‐Šeler, Dorotea; Kozarić‐Kovačić, Dragica; Balija, Melita; Matijević, Tanja; Pavelić, Jasminka

doi:10.1016/j.lfs.2005.12.030

Cited by 26 publications

(20 citation statements)

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“…Platelet MAO activity is reduced in healthy male smokers compared to nonsmokers (Berlin and Anthenelli, 2001;Pivac et al, 2006b). Since a high proportion of our patients were smokers, our data might indicate that the effect of smoking was abolished by the diagnosis.…”

Section: Discussionmentioning

confidence: 63%

Platelet serotonin and serum lipids in psychotic mania

Šagud¹,

Mihaljević-Peleš²,

Pivac³

et al. 2007

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 63%

Platelet serotonin and serum lipids in psychotic mania

Šagud¹,

Mihaljević-Peleš²,

Pivac³

et al. 2007

Journal of Affective Disorders

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“…The A/G (A644G) noncoding SNP (rs1799836) of MAOB is responsible for altered enzyme activity with tissue specificity [28, 29]. This MAOB SNP was found to be associated with emotional regulation [30, 31] and Parkinson's disease [32].…”

Section: Discussionmentioning

confidence: 99%

Genetic Variants of Neurotransmitter‐Related Genes and miRNAs in Egyptian Autistic Patients

Salem

Ismail

Zarouk

et al. 2013

The Scientific World Journal

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Autism is a neurodevelopmental disorder with indisputable evidence for a genetic component. This work studied the association of autism with genetic variations in neurotransmitter-related genes, including MAOA uVNTR, MAOB rs1799836, and DRD2 TaqI A in 53 autistic patients and 30 healthy individuals. The study also analyzed sequence variations of miR-431 and miR-21. MAOA uVNTR was genotyped by PCR, MAOB and DRD2 polymorphisms were analyzed by PCR-based RFLP, and miR-431 and miR-21 were sequenced. Low expressing allele of MAOA uVNTR was frequently higher in female patients compared to that in controls (OR = 2.25). MAOB G allele frequency was more significantly increased in autistic patients than in controls (P < 0.001 for both males and females). DRD2 A1+ genotype increased autism risk (OR = 5.1). Severity of autism tends to be slightly affected by MAOA/B genotype. Plasma MAOB activity was significantly reduced in G than in A allele carrying males. There was no significant difference in patients and maternal plasma MAOA/B activity compared to controls. Neither mutations nor SNPs in miR-431 and miR-21 were found among studied patients. This study threw light on some neurotransmitter-related genes suggesting their potential role in Autism pathogenesis that warrants further studies and much consideration.

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“…This finding is in agreement with alike platelet 5-HT concentrations in patients with early or late onset AD (Mimica et al 2005), but in contrast with decreased platelet 5-HT concentration in patients with AD (Kumar et al 1995), and increased platelet 5-HT concentrations in demented patients with delusions (Meszaros et al 1998) compared to 5-HT values in healthy controls. The explanation for the discrepancies between studies should be sought in different diagnoses (AD vs. dementia) and presence of delusions ( (Meszaros et al 1998), which were reported to increase platelet 5-HT concentration (Pivac et al 2006b). In addition, previous studies (Kumar et al 1995;Meszaros et al 1998) included smaller number of patients and control subjects, the severity of AD was not specified, and different methods i.e.…”

Section: Discussionmentioning

confidence: 99%