Platelet Serotonin and Platelet Aggregation in the Differential Diagnosis of Thrombocytosis

Fabris, Fabrizio; Randi, M. L.; Casonato, Alessandra; Scattolo, Novella; Girolami, Antonio

doi:10.1055/s-0038-1657298

Cited by 5 publications

(4 citation statements)

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“…In these pa tients the platelet activation in vivo with consequent release of dense bodies and alpha granule content may cause the thrombotic event; afterwards, the refracto riness on the platelets may determine in vi vo bleeding and in vitro aggregation im pairment [19]. The amount of serotonin stored in platelet-dense bodies is, in fact, statistically reduced in patients with MPD [5,9], whereas normal content of alpha granules has been reported [15]. Other studies demonstrate, in patients with MPD, high amounts of circulating ¡kg [7,13,16] and low content in alpha granules [4] as a consequence of the platelet activa tion in vivo.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Beta-Thromboglobulin in Patients with High Platelet Count

et al. 1984

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The aim of the study was to investigate the relevance of β-thromboglobulin (β tg) measurement in patients with thrombocytosis. We have, therefore, studied the level of plasma and platelet βtg in 74 patients with high platelet count in addition to the evaluation of platelet aggregation and platelet serotonin (5-HT) content. The determinations of platelet serotonin content and aggregation are confirmed to be useful in the differentiation between primary and secondary forms of thrombocytosis. The mean plasma level of βtg in patients with myeloproliferative disease was significantly raised, but the amount observed in subjects with secondary thrombocytosis is increased too. Considering the amount of βtg in relation to whole blood platelet count (βtg ratio), no difference was observed between all patients and controls. The βtg ratio allowed the identification of a group of patients with an increased ratio and a decreased βtg platelet content who showed the highest occurrence of thrombosis (66%).

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Beta-Thromboglobulin in Patients with High Platelet Count

et al. 1984

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“…All these factors may contribute to platelet and clotting activation as observed during cardio-pulmonary bypass [ 1,2] and haemodialysis [3]. The activation of this clotting system could therefore support the thrombotic risk reported in plasma exchange and thrombocytopheresis [4, 51 and also the behaviour of platelet aggregation reported in normals 161 and thrombocytosis after cytoapheresis [7].…”

Section: Introductionmentioning

confidence: 58%

Effect of heparin and aspirin on platelet and clotting activation during leukapheresis

Fabris

Casonato

Randi

et al. 1985

Eur J Clin Investigation

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Beta-thromboglobulin (beta TG), serotonin (5HT) and fibrinopeptide A (FPA) were assessed in twenty-two normal donors before, during, and at the end of leukapheresis. Seven procedures were carried out adding heparin to the circuit, and seven adding acetyl salicylic acid (ASA). The remaining eight procedures were carried out using only citrate and served as controls. Plasma beta TG increased both during and after the apheresis, together with a significant decrease of the intra-platelet content. Platelet 5HT did not show significant changes whereas FPA increased significantly. Using heparin, we obtained a complete prevention of FPA cleavage during the entire procedure, while beta TG increased at the middle of the procedure. No significant effects were observed using ASA both on beta TG and FPA levels. These features clearly indicate the activation of platelets and the thrombin generation in the apheresis circuit. Nevertheless, the activation of the clotting system seems to be predominant, as supported by the improved effect of heparin on beta TG and FPA amounts.

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“…Both thrombotic and haemorrhagic complications may occur in patients with myeloproliferative disease (MPD) [3,4,8], often as an expression of different steps of the same condition. Furthermore, no strict correlation between clinical manifestations and in creased platelet number 'per se' is seen, suggesting the presence of qualitative platelet defects in addition to the simple enhancement of platelet count.…”

mentioning

confidence: 99%

Acquired Type I von Willebrand’s Disease in a Patient with Essential Thrombocytosis

Casonato¹,

Fabris²,

Zancan³

et al. 1986

Acta Haematol

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Platelet Serotonin and Platelet Aggregation in the Differential Diagnosis of Thrombocytosis

Cited by 5 publications

References 1 publication

Clinical Significance of Beta-Thromboglobulin in Patients with High Platelet Count

Clinical Significance of Beta-Thromboglobulin in Patients with High Platelet Count

Effect of heparin and aspirin on platelet and clotting activation during leukapheresis

Acquired Type I von Willebrand’s Disease in a Patient with Essential Thrombocytosis

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