“…Recently there have been conflicting reports about the effect of PRP plasma, and there is no consensus regarding the role of PRP in bone regeneration: there are multiple favorable results of PRP regarding the improvement of proliferation of MSC in vitro and in vivo after ectopic implantation, but also in animal models with critical-size bone defects [Kasten et al, 2008b;Bi et al, 2010;Hakimi et al, 2010;Hartmann et al, 2010;Jungbluth et al, 2010;Niemeyer et al, 2010;Bae et al, 2011;Liu et al, 2011]. However, there is also a relevant number of studies reporting no or minimal effects of PRP on bone formation [Li et al, 2004;Roldan et al, 2004;Plachokova et al, 2007;Thor et al, 2007;Vasconcelos Gurgel et al, 2007;You et al, 2007;Miloro et al, 2010;Kazakos et al, 2011].…”