Platelet‐Rich Plasma, Low‐Level Laser Therapy, or Their Combination Promotes Periodontal Regeneration in Fenestration Defects: A Preliminary In Vivo Study

Nagata, Maria José Hitomi; Campos, Natália de; Messora, Michel Reis; Pola, Natália Marcumini; Santinoni, Carolina dos Santos; Bomfim, Suely Regina Mogami; Fucini, Stephen E.; Ervolino, Edílson; Almeida, Juliano Milanezi de; Theodoro, Letícia Helena; Garcia, Valdir Gouveia

doi:10.1902/jop.2013.130318

Cited by 21 publications

(17 citation statements)

References 48 publications

(67 reference statements)

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“…Recent in vitro studies have demonstrated that PRP exerts positive effects on gingival fibroblasts, 16 oral osteoblasts, 17 and periodontal ligament fibroblasts 18 . A preliminary in vivo study recently published by the present authors’ group showed that PRP promoted NC formation with a functional periodontal ligament in fenestration defects in rats 2 . However, the precise role of platelet concentrates in periodontal tissue regeneration still needs to be better clarified.…”

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confidence: 75%

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Platelet‐Rich Plasma Derived From Bone Marrow Aspirate Promotes New Cementum Formation

Nagata

Campos

Messora

et al. 2014

Journal of Periodontology

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confidence: 75%

“…Periodontal regeneration involves the formation of new alveolar bone, cementum, and functional periodontal ligament. Newer periodontal treatment modalities to enhance regeneration include the use of mesenchymal stem cells (MSCs) 1 and platelet‐rich plasma (PRP) 2 …”

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confidence: 99%

Platelet‐Rich Plasma Derived From Bone Marrow Aspirate Promotes New Cementum Formation

Nagata

Campos

Messora

et al. 2014

Journal of Periodontology

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“…With regard to the treatment of periodontal bone defects, Nagata et al. analyzed the influence of platelet‐rich plasma, low‐level laser therapy (660‐nm diode laser), separately or combined, on the healing of periodontal fenestration defects in rats. Low‐level laser therapy and platelet‐rich plasma, separately or combined, all promoted new cementum formation with a functional periodontal ligament.…”

Section: Low‐level Laser Therapymentioning

confidence: 99%

Periodontal and peri‐implant wound healing following laser therapy

Aoki¹,

Mizutani²,

Schwarz³

et al. 2015

Periodontology 2000

288

273

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Laser irradiation has numerous favorable characteristics, such as ablation or vaporization, hemostasis, biostimulation (photobiomodulation) and microbial inhibition and destruction, which induce various beneficial therapeutic effects and biological responses. Therefore, the use of lasers is considered effective and suitable for treating a variety of inflammatory and infectious oral conditions. The CO2 , neodymium-doped yttrium-aluminium-garnet (Nd:YAG) and diode lasers have mainly been used for periodontal soft-tissue management. With development of the erbium-doped yttrium-aluminium-garnet (Er:YAG) and erbium, chromium-doped yttrium-scandium-gallium-garnet (Er,Cr:YSGG) lasers, which can be applied not only on soft tissues but also on dental hard tissues, the application of lasers dramatically expanded from periodontal soft-tissue management to hard-tissue treatment. Currently, various periodontal tissues (such as gingiva, tooth roots and bone tissue), as well as titanium implant surfaces, can be treated with lasers, and a variety of dental laser systems are being employed for the management of periodontal and peri-implant diseases. In periodontics, mechanical therapy has conventionally been the mainstream of treatment; however, complete bacterial eradication and/or optimal wound healing may not be necessarily achieved with conventional mechanical therapy alone. Consequently, in addition to chemotherapy consisting of antibiotics and anti-inflammatory agents, phototherapy using lasers and light-emitting diodes has been gradually integrated with mechanical therapy to enhance subsequent wound healing by achieving thorough debridement, decontamination and tissue stimulation. With increasing evidence of benefits, therapies with low- and high-level lasers play an important role in wound healing/tissue regeneration in the treatment of periodontal and peri-implant diseases. This article discusses the outcomes of laser therapy in soft-tissue management, periodontal nonsurgical and surgical treatment, osseous surgery and peri-implant treatment, focusing on postoperative wound healing of periodontal and peri-implant tissues, based on scientific evidence from currently available basic and clinical studies, as well as on case reports.

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“…With regard to the treatment of periodontal bone defects, Nagata et al (29) analyzed the influence of platelet-rich plasma, low-level laser therapy (660-nm diode laser), separately or combined, on the healing of periodontal fenestration defects in rats. Low-level laser therapy and platelet-rich plasma, separately or combined, all promoted new cementum formation with a functional periodontal ligament.…”

Section: A Comparative Study Of the Effect Of Demineralized Bone Matrmentioning

confidence: 99%

A Comparative Study of The Effect of Demineralized Bone Matrix with and Without Low Level Laser Therapy on The Treatment of Periodontal Infra-Bony Defects (Randomized Clinical Trial)

Gamil

Eldestawy

Fekry

2019

Al-Azhar Assiut Dental Journal

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Objective: This study aimed at comparing clinically and radiographically the therapeutic effect of low level laser therapy and demineralized bone matrix, used in management of periodontal intrabony defect. Subjects and methods: Thirty two non-smoking patients aged between 28-51 years with severe chronic periodontitis participated in this randomized clinical study. Patients were randomly assigned into one of 2 groups (16 patients each): demineralized bone grafting alone of the intrabony defect, control group (Group I), demineralized bone grafting and the application of low level laser therapy (LLLT) (Group II). Clinical and radiographic parameters including plaque index, bleeding index, probing depth, clinical attachment level (CAL) and intrabony defect depth were reassessed at 6 months after surgery. Results: Specifically, LLLT treated sites (Group II) showed statistically significant differences regarding pocket depth and CAL compared with Group I. Intrabony defect depth was significantly reduced for LLLT group compared to that of Group I control. Conclusion: The use of LLLT as an adjunct with demineralized bone matrix (DBM) in the treatment of intrabony defects was more significant in improving the probing depth, CAL and intrabony defect depth than using DBM alone. Complete periodontal regeneration is unpredictable with any regenerative therapy currently used, so, periodontal bone grafts show

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Platelet‐Rich Plasma, Low‐Level Laser Therapy, or Their Combination Promotes Periodontal Regeneration in Fenestration Defects: A Preliminary In Vivo Study

Abstract: LLLT, PRP, or their combination all promoted NC formation with a functional periodontal ligament. The combination PRP/LLLT did not show additional positive effects compared to the use of either therapy alone.

Cited by 21 publications

References 48 publications

Platelet‐Rich Plasma Derived From Bone Marrow Aspirate Promotes New Cementum Formation

Platelet‐Rich Plasma Derived From Bone Marrow Aspirate Promotes New Cementum Formation

Periodontal and peri‐implant wound healing following laser therapy

A Comparative Study of The Effect of Demineralized Bone Matrix with and Without Low Level Laser Therapy on The Treatment of Periodontal Infra-Bony Defects (Randomized Clinical Trial)

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