Platelet-Rich Plasma in Sinus Augmentation Procedures: A Systematic Literature Review: Part II

Abstract

There is a paucity of clinically controlled trials regarding benefits of PRP in sinus augmentation procedures. Theoretically, it seems to have significant beneficial effects on the soft and hard tissue healing; however, the disparity in study design, surgical techniques, and different outcome assessment variables used, makes it difficult to assess the practical benefit of its clinical use. Although no obvious positive effects of PRP on healing of bone graft material in maxillary sinus augmentation procedures were noted, the handling of the particulate bone grafts was improved.

A review on endogenous regenerative technology in periodontal regenerative medicine

“…Theoretically, there seemed to be significant beneficial effects for soft and hard tissue healing; however, the disparity in study design, surgical techniques, and the different outcome assessment variables that were used, makes it difficult to assess the practical benefit of PRP's clinical use. Although no obvious positive effects of PRP on the healing of bone graft material in maxillary sinus augmentation procedures were noted, the handling of the particulate bone grafts was improved [79].…”

Experimental Study of the Effect of Autologous Platelet-Rich Plasma on the Early Phases of Osteoinduction by Allogenic Demineralized Bone Matrix

“…7 By applying PRP alone or in combination with a bone graft, the concentration of the growth factors and cell adhesion molecules will increase locally in the area of the bone defect, which seems to lead to faster and more effective bone regeneration, 8 although the handling of the particulate bone grafts is significantly improved. 9 In 1998, Marx et al 10 published a pioneering clinical study that essentially introduced the use of PRP into everyday clinical practice. Since then, numerous experimental and clinical studies have examined the effects resulting from the use of PRP alone [9][10][11][12][13] or in combination with autografts, 11,14-17 lyophilized bone allografts, 18-21 synthetic grafts, 22,23 and inorganic bovine bone [24][25][26] with various positive and negative results.…”

Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

“…The differentiation of osteoblasts from bone marrow cells is well described and standardized [26]. The PRP is rich in various growth factors released from platelets, which have been reported to increase vascular ingrowth and mitogenic effects on boneforming cells [4,11,28,57]. Second, because of the autogenous properties, their application can avoid possible complications, such as immunogenic reactions and disease transmissions, which can come from allogenic or synthetic materials.…”