Platelet-Rich Plasma in Arthroscopic Repairs of Complete Tears of the Rotator Cuff

Malavolta, Eduardo Angeli; Gracitelli, Mauro Emílio Conforto; Sunada, Edwin Eiji; Benegas, Eduardo; Prada, Flávia de Santis; Neto, Raul Bölliger; Rodrigues, Marcelo Bordalo; Neto, Arnaldo Amado Ferreira; Camargo, Olavo Pires de

doi:10.1016/s2255-4971(15)30032-x

Cited by 9 publications

(26 citation statements)

References 31 publications

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“…In this study, where we focused on wounds not associated with compromised blood and located in regions with good blood circulation, heterologous PRP may not induce faster wound reduction or alterations in tissue contraction during the repair process, similar to the results by Bauer et al 27 In contrast, some studies that presented superior effects of PRP studied chronic wounds in peripheral regions or in patients with some type of circulatory compromise 11,12,24,28 .…”

Section: Discussionsupporting

confidence: 66%

Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits

et al. 2015

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Intellectual and scientific content of the study, surgical procedures, critical revision. ABSTRACT PURPOSE:To evaluate the potential of heterologous platelet-rich plasma (PRP) gel for surgical skin wound healing in rabbits METHODS: Blood from a single healthy dog was used for PRP production, with calcium gluconate added to the PRP to form the gel.Two surgical excisions, one to the right and the other to the left of the dorsal midline, were made in six rabbits. One side was randomly allocated to topical application of a physiological solution, and the other was allocated to treatment with heterologous PRP gel. Clinical assessments (weight, pain sensitivity, coloring, edema, hyperemia, exudation, crust, and granulation) and morphometric evaluations were performed 0, 3, 7, 10, 14, and 17 days postoperatively. Histological analysis was performed on the 17 th day. RESULTS:With the exception of the presence of a crust at day 10, clinical variables did not differ significantly between the experimental groups. In both the control and PRP-treated groups, differences were identified when comparing time-points in terms of wound area reduction. Histological results indicated no significant differences between the control group and the PRP-treated group. CONCLUSION:Heterologous platelet-rich plasma gel promoted dermal wound healing in rabbits with no adverse effects.

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Section: Discussionsupporting

confidence: 66%

Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits

et al. 2015

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“…In the period evaluated, 712 original articles were published in the Brazilian Journal of Orthopedics and 588 in Acta Ortopédica Brasileira, or 1300 publications. Among these, 84 (6.7% of the total) were clinical articles on shoulder diseases; 25 publications (1.9% of the total) 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 evaluated the clinical results of treatment of rotator cuff tears ( Table 1 ); twenty studies (80%) were case series (level of evidence IV), one (4%) case–control study (level of evidence III) and four (16%) cohorts (level of evidence II). No randomized study was published in the period.…”

Section: Resultsmentioning

confidence: 99%

“…The tests were done once in all studies, and only one study performed the exam on a regular basis (12 months). 22 …”

Section: Resultsmentioning

confidence: 99%

Outcome assessment in the treatment of rotator cuff tear: what is utilized in Brazil?

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Malavolta

Domingues

et al. 2017

Revista Brasileira de Ortopedia (English Edition)

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This review evaluated the outcomes used in clinical studies involving rotator cuff tear published in the last decade in the two leading Brazilian orthopedic journals. A literature review was performed using the journals Revista Brasileira de Ortopedia and Acta Ortopédica Brasileira. It included all original clinical articles describing at least one outcome measured before or after any clinical or surgical intervention related to rotator cuff tear, published between 2006 and 2015. The authors evaluated range of motion, muscle strength, patient satisfaction, and tendon integrity and functional outcomes scores. There were 25 clinical studies published about rotator cuff in the two principal Brazilian orthopedic journals in the last decade, 20 case series (80%), one case–control (4%), and four cohorts (16%). Objective measures such as muscle strength, patient satisfaction, and evaluation of tendon integrity were little used. Range of motion measurements were performed in 52% of the articles. Evaluations of muscle strength and patient satisfaction were reported by 28% and 16% of the studies, respectively. Only 28% of the articles evaluated tendon integrity after surgery. Of these, 16% did so by magnetic resonance imaging and 12% by ultrasonography. The most used scale was the UCLA, present in 92% of the articles, while the Constant–Murley appeared in 20%. Scales deemed reliable, with high internal consistency and good responsiveness, were rarely used.

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“…The therapeutic response was significant at 1 and 3 months of treatment ( p < 0.05), but the difference from the admission score was not significant at 6 months ( p = 0.138), which can be explained by the low number of participants who finished the study. One study 12 used intraoperative PRP in arthroscopic repairs of complete ruptures of the rotator cuff and found that PRP has positive results in the CMS and UCLA scores.…”

Section: Discussionmentioning

confidence: 99%

Plasma rico em plaquetas e corticoide no tratamento da síndrome de impacto do manguito rotador: Ensaio Clínico randomizado

et al. 2019

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Objective This research aims to study the effectiveness of platelet-rich plasma (PRP) in the treatment of patients with rotator cuff impingement syndrome compared with the treatment with subacromial injection of corticosteroids. Methods This is a double-blind, randomized, comparative clinical trial. The patients were clinically evaluated with the use of the Disabilities of the Arm, Shoulder and Hand (DASH) outcome measure, University of California Los Angeles (UCLA) shoulder rating scale and Constant-Murley shoulder outcome score (CMS) on the day of application, and then again after 1, 3 and 6 months. Results No statistically significant differences were found ( p < 0.05) when comparing the results of the DASH outcome measure, UCLA shoulder rating scale and CMS of the two groups at baseline and after 1, 3, and 6 months of treatment with subacromial injection. After the treatment, both groups showed a significant improvement in the DASH and UCLA scores ( p < 0.05) when compared with the baseline. However, the CMS at 6 months after treatment with steroids was lower than the baseline. Concusions These findings suggest that PRP is a safe treatment and can be a useful tool in the therapeutic arsenal against of the rotator cuff diseases, for there was no significant difference between the subacromial use of PRP and corticosteroids.

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Platelet-Rich Plasma in Arthroscopic Repairs of Complete Tears of the Rotator Cuff

Cited by 9 publications

References 31 publications

Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits

Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits

Outcome assessment in the treatment of rotator cuff tear: what is utilized in Brazil?

Plasma rico em plaquetas e corticoide no tratamento da síndrome de impacto do manguito rotador: Ensaio Clínico randomizado

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