Platelet-Rich Plasma in a Patient with Cerebral Palsy

Abstract

Patient: Male, 6Final Diagnosis: Cerebral palsy secundary perinatal hypoxiaSymptoms: Cognitive impairment • epilectic seizureMedication: Platelet rich plasmaClinical Procedure: Cognitive improvement with neuroestimulator and neuroregenerator power of platelet rich plasma injectionSpecialty: HematologyObjective:Unusual clinical courseBackground:The use of platelet-rich plasma is a now a common medical technique known as regenerative medicine, through power cell activation and differentiation, which produces growth factors called platelets derived both locally and systematically. Here, we report the case of a cerebral palsy patient who received intravenous platelet-rich plasma.Case Report:We administered an intravenous injection of concentrated platelet-rich plasma (25 cc) in a 6-year-old boy with perinatal cerebral palsy, cognitive impairment, and marked and severe generalized spasticity. We performed follow-up at 3 and 6 months after the injection. All serum samples for determination were obtained by ELISA technique. Cognitive scales (Bayley, Battelle, M.S.C.A, Kaufman ABC, and Stanford-Binet Intelligence scale) were used before and after treatment. The determination protocol that was applied before the analysis was performed manually and the autotransfusion was considered suitable for treatment. We determined the plasma levels of factor similar to insulin-1 (IGF-1), platelet-derived growth factor (PDGF), vasculo-endothelial growth factor (VEGF), and transforming growth factor B (TGF-B) before and during treatment monitoring.Conclusions:No adverse effects were observed in the patient except for a small hematoma in the area channeling venous access. We observed a clear improvement in the cognitive sphere (memory, ability to perform more complex tasks, and acquisition of new skills) and in language, maintaining stable levels of growth factor in plasma 3–5 times higher than average for his age group at both 3- and 6-month follow-up. Positron emission tomography (PET) images showed an evident increased demarcation in the cerebral cortex. We propose that this therapy is useful in these patients to harness the neurostimulative and neuroregenerative power of endogenous growth factors derived from platelets.

Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study

“…PRP can stimulate proliferation and regeneration with a large amount of growth factors and cytokines, including PDGF, TGF, VGEF, EGF, fibroblast growth factor (FGF), insulin-like growth factor I, II (IGF I, II), interleukin 8 (IL-8) and connective tissue growth factor (CTGF). Currently, PRP infusion is being increasingly used in several fields in medicine such as nerve injury, osteoarthritis, chronic tendinitis, bone repair and regeneration, cardiac muscles, alopecia, plastic surgery and oral surgery, but there is limited experience in gynecology and obstetrics (Alcaraz et al , 2015; Borrione et al , 2010; Patel et al , 2016; Yu et al , 2011). …”

Plasma Tumor Necrosis Factor-alpha (TNF-α) Levels Correlate with Disease Severity in Spastic Diplegia, Triplegia, and Quadriplegia in Children with Cerebral Palsy

“…Since therapies targeting activated microglia and astrocytes or anti-cytokine treatments may help reduce the injury of cerebral palsy [ 33 ], therapeutic interventions designed to reduce inflammation may yield beneficial results in children throughout childhood. Recently, Alcaraz et al [ 34 ] reported the use of platelet-rich plasma for the treatment of a patient with cerebral palsy, leading to improvements in the cognitive score and motor functions. Another study reported decreased pro-inflammatory factors after allogeneic umbilical cord blood transplantation [ 35 ].…”