Platelet‐rich plasma for resistant oral erosions of pemphigus vulgaris: A pilot study

El-Komy, Mohamed H.M.; Hassan, Akmal S.; Raheem, Heba M. Abdel; Doss, Sally; EL-Kaliouby, Mona; Saleh, Noha A.; Saleh, Marwah Adly

doi:10.1111/wrr.12363

Cited by 25 publications

(20 citation statements)

References 5 publications

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“…In 2015, El-Komy and his colleagues conducted a pilot study on seven patients suffering from resistant chronic oral pemphigus vulgaris (PV). All patients reported improvement in pain scores, ability to eat, and healing score [60].…”

Section: Autogenous Blood Productsmentioning

confidence: 95%

Oral Mesotherapy: Might Be Considered as An Adjunctive Technique for the Different Surgical Procedures?

Yussif¹

2020

Periodontal Disease - Diagnostic and Adjunctive Non-Surgical Considerations

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The bidirectional relationship between local and systemic pathways makes it difficult to provide a safe intraoral treatment. Nowadays, mesotherapy has become more necessary in dentistry to overcome the huge number of surgical interventions either for therapeutic or for cosmetic purposes. It also limits the need for systemic drugs achieving favorable outcomes with minimal side effects. Further researches are needed to examine the usage of mesotherapy in different oral problems. In dermal mesotherapy, dermatologists used several materials as hyaluronic acid, collagen, hydroxyapatite, carboxymethyl cellulose, and silicone. Such materials exhibit different manners according to their resorption rate: temporary, semipermanent, permanent, and combinations. Furthermore, B-tricalcium phosphate and hydroxyapatite are considered as tissue stimulators by stimulation of collagen formation. Combinations of temporary materials in order to achieve immediate filling effect with tissue stimulator as HA or B-TCP achieve better results.

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Section: Autogenous Blood Productsmentioning

confidence: 95%

Oral Mesotherapy: Might Be Considered as An Adjunctive Technique for the Different Surgical Procedures?

Yussif¹

2020

Periodontal Disease - Diagnostic and Adjunctive Non-Surgical Considerations

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“…PRP, which is concentrated plasma derived from autologous whole blood, is believed to promote wound healing (60). In a case report series, El-Komy et al reported that six of seven PV patients showed improvement of their oral PDAI scores after PRP intralesional injection (61). To evaluate the effects of PRP in PV, an open-label, dose-escalation, multicenter phase 1 trial using autologous PRP has been conducted in adults with active PV ( NCT02828163 ).…”

Section: Pemphigusmentioning

confidence: 99%

Current Clinical Trials in Pemphigus and Pemphigoid

2019

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Autoimmune bullous dermatoses (AIBDs) are a group of rare chronic inflammatory skin diseases, which clinically manifest as blisters and erosions of the skin and/or mucosa. Immunologically, AIBDs are characterized and caused by autoantibodies targeting adhesion molecules in the skin and mucosa. According to the histological location of the blistering, AIBDs are classified into the following two main subtypes: pemphigus (intraepidermal blistering) and pemphigoid (subepidermal blistering). Most AIBDs were potentially life-threatening diseases before the advent of immunosuppressive drugs, especially systemic steroid therapies, which suppress pathogenic immunological activity. Although there have been recent advancements in the understanding of the pathogenesis of AIBDs, glucocorticosteroids and/or adjuvant immunosuppressive drugs are still needed to control disease activity. However, the long-term use of systemic immunosuppression is associated with major adverse events, including death. Based on the growing understanding of AIBD pathogenesis, novel treatment targets have emerged, some of which are currently being evaluated in clinical trials. Within this article, we review the current clinical trials involving pemphigus and pemphigoid and discuss the rationale that lead to these trials. Overall, we aim to foster insights into translational research in AIBDs to improve patient care.

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“…It manifests in oral cavity as painful erosive lesions (ulcers) that are usually treated with corticosteroids (116). In such cases, the repeated injections of PRP accelerate tissue healing and reduce pain and discomfort during mastication (106). Oral ulcers can also occur after bone marrow allogeneic transplants resulting in graft vs. host disease (GvHD).…”

Section: Regenerative Properties Of Platelet Granulesmentioning

confidence: 99%

Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration

Al-Hamed

Mahri

Al-Waeli

et al. 2019

Front. Cardiovasc. Med.

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Platelet concentrates (PCs) are biological autologous products derived from the patient's whole blood and consist mainly of supraphysiologic concentration of platelets and growth factors (GFs). These GFs have anti-inflammatory and healing enhancing properties. Overall, PCs seem to enhance bone and soft tissue healing in alveolar ridge augmentation, periodontal surgery, socket preservation, implant surgery, endodontic regeneration, sinus augmentation, bisphosphonate related osteonecrosis of the jaw (BRONJ), osteoradionecrosis, closure of oroantral communication (OAC), and oral ulcers. On the other hand, no effect was reported for gingival recession and guided tissue regeneration (GTR) procedures. Also, PCs could reduce pain and inflammatory complications in temporomandibular disorders (TMDs), oral ulcers, and extraction sockets. However, these effects have been clinically inconsistent across the literature. Differences in study designs and types of PCs used with variable concentration of platelets, GFs, and leucocytes, as well as different application forms and techniques could explain these contradictory results. This study aims to review the clinical applications of PCs in oral and craniofacial tissue regeneration and the role of their molecular components in tissue healing.

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Platelet‐rich plasma for resistant oral erosions of pemphigus vulgaris: A pilot study

Cited by 25 publications

References 5 publications

Oral Mesotherapy: Might Be Considered as An Adjunctive Technique for the Different Surgical Procedures?

Oral Mesotherapy: Might Be Considered as An Adjunctive Technique for the Different Surgical Procedures?

Current Clinical Trials in Pemphigus and Pemphigoid

Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration

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