Platelet Rich Fibrin (PRF) Application in Oral Surgery

Abstract

Platelet rich fibrin (PRF) is an autologous biological product which becomes popular day by day and available in a wide variety of fields in medicine. Platelet concentrates which are introduced at the early 90s have evolved over the years. The use such autologous materials have become trendy in recent years to encounter demanding expectations of patients, improve treatment success and maximize patient comfort. Despite its increasing use in dentistry and oral surgery, the most indications and effects are still being discussed. PRF is easily accepted by patients because of its low cost, easy to receive, low donor morbidity, low postoperative complication and infection rate. This biomaterial may be a solution for patients who have strong negative beliefs about the use of allografts and xenografts or who are afraid of complications during the grafting procedure. The objectives of these technologies are to use their synergistic effect to improve the hard and soft tissue regeneration. PRF in oral surgery are used for alveolar bone reconstruction, dental implant surgery, sinus augmentation, socket preservation, osteonecrosis, oroantral fistula closure, struggling with oral ulcers, preventing swelling and edema constitution. This chapter aims to review the clinical applications of platelets in oral surgery and the role of molecular components in tissue healing.

Topical Biological Agents as Adjuncts to Improve Wound Healing in Chronic Diabetic Wounds: A Systematic Review of Clinical Evidence and Future Directions

“…PRF serves as a supportive template for tissue regeneration by guiding clot formation through sustaining growth factors and stem cells as a naturally forming fibrin scaffold. There are many applications of PRF in cosmetic medicine and surgery [38][39]. Further research is expected to uncover more benefits to be obtained from PRF's regenerative properties, bioavailability, and autologous nature.…”

Treatment of exposed inferior alveolar neurovascular bundle with PRF during surgical removal of impacted lower third molars

“…For that reason, has been widely used in the oral and maxillofacial surgery [8]. There are several types of PRF depending on the time and centrifuge speed such as A-PRF, P-PRF, L-PRF, Liquid-PRF and I-PRF [9].…”

Effectiveness of platelet rich fibrin versus demineralized bone xenograft in periodontally accelerated osteogenic orthodontics:

“…i-PRF is a platelet concentrate in liquid form that can be polymerized with bone graft xenograft and is known as sticky bone (sticky PRF), an emerging trend that has gained applications in periodontology and implantology. [12][13][14] There is a paucity of data on the possibility of incorporating L-PRF in PAOO toward achieving a better surgical outcome and healing and the graft materials used in PAOO have not been compared. [15][16][17] The aim of this pilot study was to compare the effectiveness of PRF vs demineralized bone xenograft (DMBM) in affecting the rate of space closure and early wound healing in the PAOO procedure.…”