Effectiveness of platelet rich fibrin versus demineralized bone xenograft in periodontally accelerated osteogenic orthodontics:

Abstract

Objectives To compare the rate of extraction space closure between periodontally accelerated osteogenic orthodontics (PAOO) using platelet-rich fibrin (PRF) (Group 1) and PAOO using demineralized bone xenograft (DMBM) (Group 2) and to compare the level of wound healing between the PRF group vs the DMBM group after PAOO. Materials and Methods A two-arm prospective single blind pilot study with a split-mouth design was used in which 14 patients requiring premolar extraction were divided into two groups: PRF and DMBM. En-masse space closure was carried out with using mini implants after the PAOO procedure. The amount of space closure was measured at five time points with 2-week intervals within 2 months. The gingival healing levels were assessed using early wound healing scores on the first postoperative day. Results The rate of extraction space closure was faster in the experimental quadrant at all time points (T1-T4) in the PRF group and at time points (T3, T4) in the DMBM group. Comparison between experimental quadrants showed a significant increase in the rate of space closure in the PRF group T1 to T3 (P < .05). The PRF group showed higher total early healing scores than the DMBM group. Conclusions PRF, when used in the PAOO procedure, produces a faster rate of space closure with better early wound healing than DMBM.

Evaluation of the Difference in the Rate of Canine Retraction Assisted by Piezocision and Discission in Human Subjects: A Preliminary Parallel-Arm Prospective Clinical Study

“…Exploring this aspect could be a future scope for comparison as augmentation with materials like platelet-rich fibrin and bone-grafts has demonstrated synergistic effects. 16 , 27 …”

“…The level of statistical significance level was set at p≤0.05. 16 This parallel arm study was approved by the Institute’s Scientific Review Board and Ethical Committee of SRM Dental College (approval no: SRMDC/IRB/2019/MDS/No.108A, date: 04.01.2022) and was registered under the Clinical Trial Registry. The study was designed as a preliminary parallel-arm investigation following a split mouth study design, where one quadrant of the maxillary arch served as the corticotomy side and the opposite side serving as the control ( Figure 1 ).…”

Research Hotspots and Trends of Bone Xenograft in Clinical Procedures: A Bibliometric and Visual Analysis of the Past Decade

“…It is rich in platelets, white blood cells, mononuclear cells, and various cytokines, with advantages such as simple preparation, no immunogenicity, and easy clinical application [ 76 , 77 ]. In vitro, studies have shown that PRF exhibits properties such as promoting angiogenesis and has achieved good results when used in conjunction with xenografts in studies on ARP, guided bone regeneration, periodontal regeneration, MSFE, and accelerated orthodontic tooth movement [ 15 , 46 , 78 , 79 , 80 , 81 ]. Studies have found that different centrifugal processes may alter the 3D network structure of PRF, which may potentially affect the efficacy of related bone-augmentation techniques [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ].…”

“…In vitro, studies have shown that PRF exhibits properties such as promoting angiogenesis and has achieved good results when used in conjunction with xenografts in studies on ARP, guided bone regeneration, periodontal regeneration, MSFE, and accelerated orthodontic tooth movement [ 15 , 46 , 78 , 79 , 80 , 81 ]. Studies have found that different centrifugal processes may alter the 3D network structure of PRF, which may potentially affect the efficacy of related bone-augmentation techniques [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ]. Based on the above background, PRF has great research potential in enhancing the performance of bone xenografts and is one of the future research hotspots.…”