“…It is rich in platelets, white blood cells, mononuclear cells, and various cytokines, with advantages such as simple preparation, no immunogenicity, and easy clinical application [ 76 , 77 ]. In vitro, studies have shown that PRF exhibits properties such as promoting angiogenesis and has achieved good results when used in conjunction with xenografts in studies on ARP, guided bone regeneration, periodontal regeneration, MSFE, and accelerated orthodontic tooth movement [ 15 , 46 , 78 , 79 , 80 , 81 ]. Studies have found that different centrifugal processes may alter the 3D network structure of PRF, which may potentially affect the efficacy of related bone-augmentation techniques [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ].…”