Platelet rich fibrin: New treatment modality in Grade II furcation defects

Mehta, Dhruv Bipinchandra; Deshpande, Neeraj; Dave, Deepak; Bhavesh, Modi; Bharwani, Ashit

doi:10.15713/ins.jodm.7

Cited by 3 publications

(3 citation statements)

References 11 publications

(18 reference statements)

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“…Amoxicillin (500 mg) and ibuprofen (800 mg) were prescribed thrice daily for 7 days along with 0.2% chlorhexidine digluconate mouth rinses twice daily for 2 weeks. 19 Postoperative follow-up care Periodontal dressing and sutures were removed 2 weeks postoperatively. Surgical wounds were gently cleansed with 0.12% of chlorhexidine (chlorhexidine digluconate) (PerioGard r ), and patients were instructed for gentle brushing with a soft toothbrush.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Platelet-rich fibrin in combination with decalcified freeze-dried bone allograft for the management of mandibular degree II furcation defect: A randomised controlled clinical trial

Agarwal¹,

Manjunath²,

Sethi³

et al. 2019

Singapore Dent J

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Background: Treatment of furcation involvement of molars with periodontal disease remains challenging and unpredictable. Platelet-rich fibrin (PRF) has received the attention of researchers due to its pleiotropic properties essential for periodontal wound healing. The osteoinductive property of demineralized freeze-dried bone allograft (DFDBA) has been successfully used in periodontal regeneration. Aim: The present study aimed to explore the effectiveness of PRF alone and with DFDBA in the treatment of mandibular degree II furcation defects in subjects with chronic periodontitis. Material and Methods: Patients treated were from the Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly. A total of 60 mandibular molars were treated with either open flap debridement (OFD) alone, [Formula: see text] combination or [Formula: see text] combination. The soft and hard tissue parameters such as vertical probing depth (VPD), vertical clinical attachment level (VCAL), gingival marginal level (GML), horizontal probing depth (HPD), vertical bone fill (VBF), horizontal bone fill (HBF) and furcation width (FW) were determined at baseline and 9 months postoperatively. A paired [Formula: see text]-test was conducted to assess the statistical significance between time period within each group for clinical and radiographic parameters. ANOVA and post-hoc Tukey’s tests were also conducted for intergroup comparison of soft and hard tissue parameters. Statistical significance was set at [Formula: see text]. Results and Discussion: After 9 months, all treatment groups showed significant ([Formula: see text]) improvement in soft and hard tissue parameters, except GML in all the three groups and HBF and FW in the OFD group as compared to baseline. The mean VBF change was highest in the [Formula: see text] group ([Formula: see text]) mm, followed by that in the [Formula: see text] and OFD groups ([Formula: see text] and [Formula: see text][Formula: see text]mm, respectively). Conclusions: It was shown that both [Formula: see text] and [Formula: see text] combinations were significantly advantageous for the management of mandibular degree II furcation defects. However, the [Formula: see text] combination has significantly greater benefits than [Formula: see text] combination in terms of VBF.

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Section: Surgical Proceduresmentioning

confidence: 99%

Platelet-rich fibrin in combination with decalcified freeze-dried bone allograft for the management of mandibular degree II furcation defect: A randomised controlled clinical trial

Agarwal¹,

Manjunath²,

Sethi³

et al. 2019

Singapore Dent J

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“…To the best of our knowledge, there were no studies comparing the use of PRF as membrane and that of collagen membrane in the treatment of furcation defects. When comparing change in clinical and radiologic parameters with other regenerative materials, PRF shows a greater effect in soft- and hard-tissue regeneration,[ 5 ] especially considering first-generation platelet concentrate (PRP). All the clinical and radiographic parameters showed better results for the PRF group in this study.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of platelet-rich fibrin membrane and collagen membrane along with demineralized freeze-dried bone allograft in Grade II furcation defects: A randomized controlled study

Mehta

Deshpande

Dandekar

2018

J Indian Soc Periodontol

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Background:The management of the furcation areas in multirooted teeth is often challenging due to difficulty in access. Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has shown to accelerate the healing of soft and hard tissues. This study was designed to evaluate the efficacy of autologous PRF as a membrane in treatment of Grade II furcation defects in molars as compared to collagen membrane along with demineralized freeze-dried bone allograft in both the groups.Materials and Methods:A split-mouth study was planned with 18 patients having 2 sites of Grade II furcation defects each. Random allocation of the defect site was done for the test and control group. Plaque index, probing depth (PD), relative vertical clinical attachment level (RVCAL), gingival marginal level, and radiographic bone levels were recorded at baseline, 3 months, and 6 months postoperatively.Results:Both the groups showed statistically significant outcomes in intragroup comparison from baseline to 3 and 6 months. However, there was no statistical difference between PRF membrane and collagen membrane groups on intergroup comparison.Conclusion:There was a significant reduction of PD, improvement in RVCAL, and defect fill with autogenous PRF as membrane. This indicates its role as a regenerative material in treating furcation defects, which can be used as alternative to other expensive membranes.

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“…Two generations of platelet concentrates were used to enhance periodontal regeneration. The first generation includes platelet rich plasma (PRP) production protocols, while the second generation is the platelet rich fibrin (PRF) (5).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Platelet Rich Fibrin on Angiogenesis During Periodontal Regeneration

Samuel

Khadr

Koura

et al. 2017

Alexandria Dental Journal

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INTRODUCTION:Platelet rich fibrin (PRF) is an autologous healing biomaterial composed of a fibrin clot matrix entrapping leukocytes, cytokines, living progenitor cells, and platelets capable of releasing various growth factors harvested from a simple blood sample. OBJECTIVES: The aim of this experimental study was to evaluate the effect of PRF on angiogenesis during the periodontal regeneration of surgically created grade ΙΙ furcation defects in dogs. MATERIALS AND METHODS: A split mouth design was carried out using the third and fourth mandibular premolars of 2 healthy mongrel adult dogs. A total of eight grade II furcation defects were surgically created. The defects in the study side were augmented with PRF mixed with a β-TCP and covered by a PRF membrane and a collagen membrane. In the control side the defects were augmented with β-TCP and covered with a collagen membrane. The dogs were sacrificed after 1 and 2 months. Samples were dissected and prepared for histological evaluation. RESULTS: Histological results showed that PRF addition led to higher vascularization of the study samples at all age groups; this was evident at one month in the form of numerous blood vessels entrapping RBCs and at 2 months by the presence of red bone marrow and blood vessels entrapping RBCs within. CONCLUSIONS: The addition of PRF to β -TCP was found to be effective in enhancing angiogenesis during the periodontal regeneration of grade II furcation defects.

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Platelet rich fibrin: New treatment modality in Grade II furcation defects

Cited by 3 publications

References 11 publications

Platelet-rich fibrin in combination with decalcified freeze-dried bone allograft for the management of mandibular degree II furcation defect: A randomised controlled clinical trial

Platelet-rich fibrin in combination with decalcified freeze-dried bone allograft for the management of mandibular degree II furcation defect: A randomised controlled clinical trial

Comparative evaluation of platelet-rich fibrin membrane and collagen membrane along with demineralized freeze-dried bone allograft in Grade II furcation defects: A randomized controlled study

The Effect of Platelet Rich Fibrin on Angiogenesis During Periodontal Regeneration

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