INTRODUCTION:Conventional periodontal therapy is an effective line of treatment for moderate periodontitis patients. Act of adjunctive use of other biomaterials assist in increasing the success of this therapy. One of these adjunctive treatments is the use of tea tree oil (TTO) as a locally delivered agent. OBJECTIVE: The present work aims to assess clinically the effect of intra pocket application of TTO gel in patients with moderate periodontitis. MATERIALS AND METHODS: this randomized controlled clinical trial was performed on a total number of thirty pockets in thirty patients with moderate periodontitis. They were classified into a control group which comprised fifteen patients treated with scaling and root planing SRP only and a test group which comprised fifteen patients treated with SRP and locally delivered TTO gel. The clinical parameters measured were: Probing pocket depth, clinical attachment level and bleeding upon probing. These were evaluated from baseline examination to three months follow-up. RESULTS:The clinical parameters showed improvement in the test group when compared to control group. CONCLUSION: The local delivery of TTO gel in conjunction with conventional periodontal treatment in moderate periodontitis is more effective than SRP therapy alone.

INTRODUCTION:Platelet rich fibrin (PRF) is an autologous healing biomaterial composed of a fibrin clot matrix entrapping leukocytes, cytokines, living progenitor cells, and platelets capable of releasing various growth factors harvested from a simple blood sample. OBJECTIVES: The aim of this experimental study was to evaluate the effect of PRF on angiogenesis during the periodontal regeneration of surgically created grade ΙΙ furcation defects in dogs. MATERIALS AND METHODS: A split mouth design was carried out using the third and fourth mandibular premolars of 2 healthy mongrel adult dogs. A total of eight grade II furcation defects were surgically created. The defects in the study side were augmented with PRF mixed with a β-TCP and covered by a PRF membrane and a collagen membrane. In the control side the defects were augmented with β-TCP and covered with a collagen membrane. The dogs were sacrificed after 1 and 2 months. Samples were dissected and prepared for histological evaluation. RESULTS: Histological results showed that PRF addition led to higher vascularization of the study samples at all age groups; this was evident at one month in the form of numerous blood vessels entrapping RBCs and at 2 months by the presence of red bone marrow and blood vessels entrapping RBCs within. CONCLUSIONS: The addition of PRF to β -TCP was found to be effective in enhancing angiogenesis during the periodontal regeneration of grade II furcation defects.