Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia

Schrottmaier, Waltraud C.; Kral-Pointner, Julia B.; Salzmann, Manuel; Mußbacher, Marion; Schmuckenschlager, Anna; Pirabe, Anita; Brunnthaler, Laura; Kuttke, Mario; Maier, Bárbara; Heber, Stefan; Datler, Hannes; Ekici, Yasemin; Niederreiter, Birgit; Heber, Ulrike; Blomgren, Bo; Gorki, Anna-Dorothea; Söderberg‐Nauclér, Cecilia; Payrastre, Bernard; Gratacap, Marie-Pierre; Knapp, Sylvia; Schabbauer, Gernot; Assinger, Alice

doi:10.1016/j.celrep.2022.111614

Cited by 5 publications

(2 citation statements)

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“…Alternative strategies involve impeding platelet–leukocyte interactions, blocking alternative surface receptors, 75 or inhibition of intracellular signaling pathways such as immunoreceptor tyrosine-based activation motif signaling or phosphoinositide 3 kinase signaling. 76 77 78 Likewise, novel methods to inhibit the coagulation cascade are in development. FXI inhibitors show promising results in clinical trials 79 and also strategies for FXII inhibition are currently under investigation 80 .…”

Section: Discussionmentioning

confidence: 99%

The Concept of Thromboinflammation

Schrottmaier,

Assinger

2024

Hamostaseologie

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Inflammation and thrombosis are intricate and closely interconnected biological processes that are not yet fully understood and lack effective targeted therapeutic approaches. Thrombosis initiated by inflammatory responses, known as immunothrombosis, can confer advantages to the host by constraining the spread of pathogens within the bloodstream. Conversely, platelets and the coagulation cascade can influence inflammatory responses through interactions with immune cells, endothelium, or complement system. These interactions can lead to a state of heightened inflammation resulting from thrombotic processes, termed as thromboinflammation. This review aims to comprehensively summarize the existing knowledge of thromboinflammation and addressing its significance as a challenging clinical issue.

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Section: Discussionmentioning

confidence: 99%

The Concept of Thromboinflammation

Schrottmaier,

Assinger

2024

Hamostaseologie

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“…In a murine model of Klebsiella pneumoniae-induced pulmonary inflammation, Toll-like receptor 4 (TLR4) deficiency in platelets decreased the number of neutrophils in the lung (29). Inhibition of platelet p110β (the catalytic subunit of phosphatidylinositol 3-kinase) prevented plateletneutrophil interactions, diminishing neutrophil infiltration (30). It was also reported that activated platelet-derived nanovesicles could recruit neutrophils to exert anti-tumor effects (31).…”

Section: Neutrophilsmentioning

confidence: 99%

Platelet, a key regulator of innate and adaptive immunity

Chen

Fang

et al. 2023

Front. Med.

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Platelets, anucleate blood components, represent the major cell type involved in the regulation of hemostasis and thrombosis. In addition to performing haemostatic roles, platelets can influence both innate and adaptive immune responses. In this review, we summarize the development of platelets and their functions in hemostasis. We also discuss the interactions between platelet products and innate or adaptive immune cells, including neutrophils, monocytes, macrophages, T cells, B cells and dendritic cells. Activated platelets and released molecules regulate the differentiation and function of these cells via platelet-derived receptors or secreting molecules. Platelets have dual effects on nearly all immune cells. Understanding the exact mechanisms underlying these effects will enable further application of platelet transfusion.

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