Platelet, a key regulator of innate and adaptive immunity

Chen, Yan; Wu, Hongxun; Fang, Xianchun; He, Jian; Zhu, Feng

doi:10.3389/fmed.2023.1074878

Cited by 6 publications

(5 citation statements)

References 162 publications

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“…Both platelets and more recently RBCs have been studied for their immunological effects and interactions with immune cells (Butler, 1989 ; Caillon et al., 2022 ; Ebeyer‐Masotta et al., 2022 ; Hemler, 2005 ; Kowal et al., 2016 ; Noris & Galbusera, 2023 ; Weiss et al., 2018 ; Yan et al., 2023 ). Further, EVs from platelet and RBCs in blood and plasma have been proposed to be key players in intercellular signalling and modulate immune responses in their microenvironment, especially by triggering signalling pathways but also directly by transferring receptors and inflammatory mediators from cell to cell (Danesh et al., 2014 ; Kuo et al., 2017 ; Mantel et al., 2016 ; Straat et al., 2016 ; Yáñez‐Mó et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Distinct targeting and uptake of platelet and red blood cell‐derived extracellular vesicles into immune cells

Ilvonen,

Pusa,

Härkönen

et al. 2024

J of Extracellular Bio

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Blood‐derived extracellular vesicles (EVs) hold great therapeutic potential. As blood contains mixed EV populations, it is challenging to study EVs originating from different cells separately. Blood cell concentrates manufactured in blood banks offer an excellent non‐invasive source of blood cell‐specific EV populations. To study blood cell‐specific EVs, we isolated EVs from platelet (TREVs) and red blood cell (EryEVs) concentrates and characterized them using nanoparticle tracking analysis, imaging flow cytometry, electron microscopy and western blot analysis and co‐cultured them with peripheral blood mononuclear cells (PBMCs). Our aim was to use imaging flow cytometry to investigate EV interaction with PBMCs as well as study their effects on T‐lymphocyte populations to better understand their possible biological functions. As a conclusion, TREVs interacted with PBMCs more than EryEVs. Distinctively, TREVs were uptaken into CD11c+ monocytes rapidly and into CD19+ B‐lymphocytes in 24 h. EryEVs were not uptaken into CD11c+ monocytes before the 24‐h time point, and they were only seen on the surface of lymphocytes. Neither TREVs nor EryEV were uptaken into CD3+ T‐lymphocytes and no effect on T‐cell populations was detected. We have previously seen similar differences in targeting PC‐3 cancer cells. Further studies are needed to address the functional properties of blood cell concentrate‐derived EVs. This study demonstrates that imaging flow cytometry can be used to study the distinctive differences in the interaction and uptake of EVs. Considering our current and previous results, EVs present a new valuable component for the future development of blood‐derived therapeutics.

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Section: Discussionmentioning

confidence: 99%

Distinct targeting and uptake of platelet and red blood cell‐derived extracellular vesicles into immune cells

Ilvonen,

Pusa,

Härkönen

et al. 2024

J of Extracellular Bio

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“…Additionally, platelet products induce interactions among innate or adaptive immune cells such as neutrophils, monocytes, macrophages, T cells, and B cells. 7 These findings suggest that inflammatory responses may differ between snAIH and spAIH groups.…”

Section: Introductionmentioning

confidence: 93%

Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index

Mutlu Bilgiç

2024

Journal of Health Sciences and Medicine

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Aims: It is suggested that a deficiency in B cells plays a role in pathogenesis of seronegative autoimmune hepatitis (snAIH). The lack of B cells leads to notable changes in the variety of leukocyte types within the bloodstream. This study aimed to determine the frequency of snAIH in patients with autoimmune hepatitis, as well as to explore the relationship between snAIH and leukocyte-based inflammatory indices. Methods: In this retrospective study, 57 patients newly diagnosed with autoimmune hepatitis were included. According to clinical and pathological findings, patients were classified into seropositive autoimmune hepatitis (spAIH) and snAIH groups. The inflammation indices included the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the systemic immune-inflammation index (SII). Results: The frequency of snAIH was 26.3%. The snAIH group exhibited higher NLR (3.0 vs. 1.5, p

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“…Activated platelets can enhance lymphocyte-endothelial cell adhesion, induce T-cell reactions, and migrate toward inflammatory regions. In kidney diseases, platelet CD40L may serve as a link between innate and adaptive immunity [176].…”

Section: Cd40/cd40l(cd154)mentioning

confidence: 99%

Platelets in Renal Disease

Gomchok,

Ge,

Wuren

2023

IJMS

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Kidney disease is a major global health concern, affecting millions of people. Nephrologists have shown interest in platelets because of coagulation disorders caused by renal diseases. With a better understanding of platelets, it has been found that these anucleate and abundant blood cells not only play a role in hemostasis, but also have important functions in inflammation and immunity. Platelets are not only affected by kidney disease, but may also contribute to kidney disease progression by mediating inflammation and immune effects. This review summarizes the current evidence regarding platelet abnormalities in renal disease, and the multiple effects of platelets on kidney disease progression. The relationship between platelets and kidney disease is still being explored, and further research can provide mechanistic insights into the relationship between thrombosis, bleeding, and inflammation related to kidney disease, and elucidate targeted therapies for patients with kidney disease.

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Platelet, a key regulator of innate and adaptive immunity

Cited by 6 publications

References 162 publications

Distinct targeting and uptake of platelet and red blood cell‐derived extracellular vesicles into immune cells

Distinct targeting and uptake of platelet and red blood cell‐derived extracellular vesicles into immune cells

Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index

Platelets in Renal Disease

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