Distinct targeting and uptake of platelet and red blood cell‐derived extracellular vesicles into immune cells
Petra Ilvonen,
Reetta Pusa,
Kai Härkönen
et al.
Abstract:Blood‐derived extracellular vesicles (EVs) hold great therapeutic potential. As blood contains mixed EV populations, it is challenging to study EVs originating from different cells separately. Blood cell concentrates manufactured in blood banks offer an excellent non‐invasive source of blood cell‐specific EV populations. To study blood cell‐specific EVs, we isolated EVs from platelet (TREVs) and red blood cell (EryEVs) concentrates and characterized them using nanoparticle tracking analysis, imaging flow cytom… Show more
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