Platelet “-omics” in health and cardiovascular disease

Gutmann, Clemens; Joshi, Abhishek; Mayr, Manuel

doi:10.1016/j.atherosclerosis.2020.05.022

Cited by 23 publications

(15 citation statements)

References 109 publications

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“…Recently, "omics" technology, such as proteomics and metabolomics, have become more accessible. This is facilitated by the decreased cost of performing these assays and the increased recognition that a large repertoire of information about platelet storage biology can be generated [26]. An untargeted metabolomic approach was used to examine the effect of cold temperature on metabolites during platelet storage.…”

Section: "Omics" and Cold-stored Plateletsmentioning

confidence: 99%

The Missing Pieces to the Cold-Stored Platelet Puzzle

Zhao

Devine

2022

IJMS

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Cold-stored platelets are making a comeback. They were abandoned in the late 1960s in favor of room-temperature stored platelets due to the need for longer post-transfusion platelet recoverability and survivability in patients with chronic thrombocytopenia. However, the current needs for platelet transfusions are rapidly changing. Today, more platelets are given to patients who are actively bleeding, such as ones receiving cardiac surgeries. It has been established that cold-stored platelets are more hemostatically effective, have reduced bacterial growth, and have longer potential shelf lives. These compelling characteristics led to the recent interest in bringing back cold-stored platelets to the blood systems. However, before reinstating cold-stored platelets in the clinics again, a thorough investigation of in vitro storage characteristics and in vivo transfusion effects is required. This review aims to provide an update on the recent research efforts into the storage characteristics and functions of cold-stored platelets using modern investigative tools. We will also discuss efforts made to improve cold-stored platelets to be a better and safer product. Finally, we will finish off with discussing the relevance of in vitro data to in vivo transfusion results and provide insights and directions for future investigations of cold-stored platelets.

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Section: "Omics" and Cold-stored Plateletsmentioning

confidence: 99%

The Missing Pieces to the Cold-Stored Platelet Puzzle

Zhao

Devine

2022

IJMS

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“…Scarce platelet proteomic evidence is currently available. When comparing patients with acute and chronic coronary syndromes, proteomic studies revealed that six out of 400 proteins studied were differently expressed [ 168 ]. Additional studies assessed protein expression and small cohorts of 10-30 patients presenting with acute vs chronic coronary syndromes.…”

Section: Platelets Proteomics In Health and Diseasementioning

confidence: 99%

Proteomics: A Tool to Study Platelet Function

Shevchuk

Begonja

Gambaryan

et al. 2021

IJMS

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Platelets are components of the blood that are highly reactive, and they quickly respond to multiple physiological and pathophysiological processes. In the last decade, it became clear that platelets are the key components of circulation, linking hemostasis, innate, and acquired immunity. Protein composition, localization, and activity are crucial for platelet function and regulation. The current state of mass spectrometry-based proteomics has tremendous potential to identify and quantify thousands of proteins from a minimal amount of material, unravel multiple post-translational modifications, and monitor platelet activity during drug treatments. This review focuses on the role of proteomics in understanding the molecular basics of the classical and newly emerging functions of platelets. including the recently described role of platelets in immunology and the development of COVID-19.The state-of-the-art proteomic technologies and their application in studying platelet biogenesis, signaling, and storage are described, and the potential of newly appeared trapped ion mobility spectrometry (TIMS) is highlighted. Additionally, implementing proteomic methods in platelet transfusion medicine, and as a diagnostic and prognostic tool, is discussed.

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“…The interaction of platelets and endothelial cells, as well as their release of extracellular vesicles (EVs), is a key process in promoting thrombogenicity and thrombosis in the context of atherosclerosis, as highlighted in several review articles in 2020 [63][64][65][66]. Therefore, there is a great need to understand the underlying pathophysiological mechanisms and their interactions with cardiovascular risk factors.…”

Section: Atherothrombosismentioning

confidence: 99%