Platelet Nitric Oxide Signaling System in Patients with Coronary Artery Disease

Garelnabi, Mahdi; Gupta, Vinod Kumar; Mallika, V.; Bhattacharjee, Jayashree

doi:10.3400/avd.oa.10.01024

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Role Of Inflammation and Oxidative Stress In Platelet Activa1

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Cited by 2 publications

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References 36 publications

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“…Although the NO-cGMP signaling system has been immensely investigated, sparse data is available pertaining to the role of platelet NO activity in coronary artery (CAD). We and others have studied the NO-cGMP system in patients with CAD, particularly the role of oxidative stress and NOmediated platelet response in IHD (Garelnabi et al 2010, Ikeda et al 2000, Garelnabi et al 2011. These studies have clearly indicated that lipid peroxidation is augmented in patients with ischemic heart disease.…”

Section: Role Of Inflammation and Oxidative Stress In Platelet Activamentioning

confidence: 99%

Platelet Activation in Ischemic Heart Disease: Role of Modulators and New Therapies

Garelnabi¹,

Horta²,

Veledar³

2012

Novel Strategies in Ischemic Heart Disease

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Section: Role Of Inflammation and Oxidative Stress In Platelet Activamentioning

confidence: 99%

Platelet Activation in Ischemic Heart Disease: Role of Modulators and New Therapies

Garelnabi¹,

Horta²,

Veledar³

2012

Novel Strategies in Ischemic Heart Disease

Self Cite

View full text Add to dashboard Cite

A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite?

Gambaryan

Tsikas

2015

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The NO/sGC/cGMP/PKG system is one of the most powerful mechanisms responsible for platelet inhibition. In numerous publications, expression of functional NO synthase (NOS) in human and mouse platelets has been reported. Constitutive and inducible NOS isoforms convert L-arginine to NO and L-citrulline. The importance of this pathway in platelets and in endothelial cells for the regulation of platelet function is discussed since decades. However, there are serious doubts in the literature concerning both expression and functionality of NOS in platelets. In this review, we aim to present and critically evaluate recent data concerning NOS expression and function in platelets, and to especially emphasise potential pitfalls of detection of NOS proteins and measurement of NOS activity. Prevailing analytical problems are probably the main sources of contradictory data on occurrence, activity and function of NOS in platelets. In this review we also address issues of how these problems can be resolved. NO donors including organic nitrites (RONO) and organic nitrate (RONO2) are inhibitors of platelet activation. Endogenous inorganic nitrite (NO2 (-)), the product of NO autoxidation, and exogenous inorganic nitrite are increasingly investigated as NO donors in the circulation. The role of platelets in the generation of NO from nitrite is also discussed.

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Platelet Nitric Oxide Signaling System in Patients with Coronary Artery Disease

Cited by 2 publications

References 36 publications

Platelet Activation in Ischemic Heart Disease: Role of Modulators and New Therapies

Platelet Activation in Ischemic Heart Disease: Role of Modulators and New Therapies

A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite?

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