A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite?

Gambaryan, Stepan; Tsikas, Dimitrios

doi:10.1007/s00726-015-1986-1

Cited by 57 publications

(38 citation statements)

References 117 publications

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“…The research was performed in a hyperbaric chamber to eliminate the effect of physical activity and the temperature of the aquatic environment. In addition, biochemical analysis was performed on natriuretic peptides (BNP and ANP) involved in the regulation of haemodynamic circulation [16–19] and vasoconstriction (urotensin II) [20]; the level of the endogenic amino acid and the nitrogen oxide precursor (L-arginine) [21–23]; and measurement of parameters involved in cardiac remodeling (angiotensin II and angiotensin (1–7)) [24–28]. …”

Section: Introductionmentioning

confidence: 99%

Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects

Kozakiewicz

Słomko

Buszko

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to explore the effect of a hyperbaric environment alone on the cardiovascular system by ensuring elimination of factors that may mask the effect on hyperbaria. The research was performed in a hyperbaric chamber to eliminate the effect of physical activity and the temperature of the aquatic environment. Biochemical analysis and examination with the Task Force Monitor device were performed before and immediately after exposure. TFM was used for noninvasive examination of the cardiovascular system and the functional evaluation of the autonomic nervous system. Natriuretic peptides were measured as biochemical markers which were involved in the regulation of haemodynamic circulation vasoconstriction (urotensin II). L-arginine acted as a precursor of the level of the nitric oxide whereas angiotensin II and angiotensin (1–7) were involved in cardiac remodeling. The study group is comprised of 18 volunteers who were professional divers of similar age and experience. The results shown in our biochemical studies do not exceed reference ranges but a statistically significant increase indicates the hyperbaric environment is not without impact upon the human body. A decrease in HR, an increase in mBP, dBP, and TPR, and increase in parasympathetic heart nerves activity suggest an increase in heart afterload with a decrease in heart activity within almost one hour after hyperbaric exposure. Results confirm that exposure to a hyperbaric environment has significant impact on the cardiovascular system. This is confirmed both by changes in peptides associated with poorer cardiovascular outcomes, where a significant increase in the studied parameters was observed, and by noninvasive examination.

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Section: Introductionmentioning

confidence: 99%

Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects

Kozakiewicz

Słomko

Buszko

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…A similar mechanism involving decreased eNOS activity may play a role in medial thickening and vascular dropout in SSc_related secondary RP . Additionally, nitric oxide is a potent inhibitor of platelet aggregation . Impairment in this functionality likely contributes to pathologic platelet aggregation that contributes to capillary thrombosis in SSc…”

Section: Role Of No In Secondary Rp and Systemic Sclerosismentioning

confidence: 99%

The clinical effects of l_arginine and asymmetric dimethylarginine: implications for treatment in secondary Raynaud's phenomenon

Curtiss

Schwager

Sicco

et al. 2018

Acad Dermatol Venereol

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Secondary Raynaud's phenomenon (RP) is often the sentinel clinical finding in systemic sclerosis and may precede systemic disease by several years. Altered nitric oxide metabolism plays a critical role in both fibrosis and severe secondary RP phenotypes in these patients. Increased flux through inducible nitric oxide synthase (iNOS) drives cutaneous fibrosis. Failure of flux through endothelial nitric oxide synthase (eNOS) contributes to increased vasoconstriction and decreased vasorelaxation. The underproduction of nitric oxide by eNOS is in part due to increased levels of asymmetric dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide synthase. The inhibitory effects of increased ADMA levels may be counteracted increasing serum l-arginine, which is often an effective treatment strategy in these patients. As such, l-arginine-based therapies should be considered in managing secondary RP, particularly given their favourable safety and tolerability profile. While there is no established dosing regimen, studies of oral l-arginine in secondary RP suggest that divided dosing may begin at 1-2 g/day and may be titrated up to 10 g/day. Conversely, primary RP is not associated with increased ADMA production which likely accounts for the failure of l-arginine trials to show benefit in primary RP.

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“…The expression and function of two NOS isoforms, eNOS and iNOS, have been reported in platelets; however, their activity and regulation are controversial (reviewed in [249]). NO produced by endothelial cells or by platelets, inhibits platelet adhesion, aggregation, recruitment, and formation of leukocyte-platelet aggregates.…”

Section: Role Of Platelets In Vascular Tone Regulation: Effects Omentioning

confidence: 99%

Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension

Gheibi

Jeddi

Kashfi

et al. 2018

Biochemical Pharmacology

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Nitric oxide (NO) and hydrogen sulfide (HS) are two gasotransmitters that are produced in the vasculature and contribute to the regulation of vascular tone. NO and HS are synthesized in both vascular smooth muscle and endothelial cells; NO functions primarily through the sGC/cGMP pathway, and HS mainly through activation of the ATP-dependent potassium channels; both leading to relaxation of vascular smooth muscle cells. A deficit in the NO/HS homeostasis is involved in the pathogenesis of various cardiovascular diseases, especially hypertension. It is now becoming increasingly clear that there are important interactions between NO and HS and that have a profound impact on vascular tone and this may provide insights into the new therapeutic interventions. The aim of this review is to provide a better understanding of individual and interactive roles of NO and HS in vascular biology. Overall, available data indicate that both NO and HS contribute to vascular (patho)physiology and in regulating blood pressure. In addition, boosting NO and HS using various dietary sources or donors could be a hopeful therapeutic strategy in the management of hypertension.

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A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite?

Cited by 57 publications

References 117 publications

Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects

Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects

The clinical effects of l_arginine and asymmetric dimethylarginine: implications for treatment in secondary Raynaud's phenomenon

Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension

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