Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy

Nadar, Sunil; Blann, Andrew D.; Lip, Gregory Y.H.

doi:10.1080/07853890410017386

Cited by 121 publications

(81 citation statements)

References 14 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mean platelet volume has been studied in many vascular diseases. Platelets play a pivotal role in atherothrombosis, the major cause of most unstable coronary syndromes and increased MPV levels have been shown as an indicator in myocardial infarcts [4,[11][12][13], congestive heart disease [13], cerebrovascular diseases [14], obesity [15] and hypertensive patients [16,17]. There is a previous study that suggested a relationship between high MPV levels and an increase in the frequency of restenosis in patients who received coronary angioplasty [18].…”

Section: Discussionmentioning

confidence: 99%

Increased mean platelet volume in type 2 diabetes mellitus

Yenigun¹

2014

Diclemedj

View full text Add to dashboard Cite

Diyabetik hastalarda vasküler komplikasyonların gelişiminde trombositler önemli rol oynamaktadır. Büyük trombositler küçüklere oranla daha aktif olup, ortalama trombosit hacmi (MPV) trombosit aktivitesini göstermede kullanılan bir belirteçdir. Biz bu çalışmamızda MPV'nin tip 2 diyabetes mellituslu hastalarda ve diyabetin mikrovasküler ve makrovasküler komplikasyonlardaki ilişkisi araştırmayı amaçladık. Yöntemler: Çalışmaya Dışkapı Eğitim ve Araştırma Hastanesi Dahiliye polikliniğinde takipli olan 48 tip 2 diyabetli ve 30 sağlıklı hasta dahil edilmiştir. Tüm hastalarda tam kan sayımı, açlık kan şekeri ve lipid parametreleri çalışıldı. Diyabetik hastalarda diyabet süresi, HbA1c düzeyi, mikrovasküler ve makrovasküler komplikasyon varlığı araştırıldı. Ortalama trombosit hacmi diyabetik ve sağlıklı kontrol grubu arasında ve diyabetik kolda komplikasyon olan olmayan grup arasında karşılaştırıldı. Bulgular: Diyabetik hastalarda MPV, non-diyabetik sağlıklılarla karşılaştırıldığında anlamlı yüksek saptandı. En az bir mikrovasküler komplikasyonu olan hastalarda olmayanlara göre MPV belirgin yüksek saptandı. Makrovasküler komplikasyonu olan hastalarda MPV olmayan hastalara göre yüksek bulundu. Sonuç: Hem diyabetiklerde hem de mikro-makrovasküler komplikasyonları olan diyabetik hastalarda MPV yüksek bulunmuştur.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased mean platelet volume in type 2 diabetes mellitus

Yenigun¹

2014

Diclemedj

View full text Add to dashboard Cite

show abstract

“…The intensity of systemic inflammation can be viewed as a distinctive factor for classifying conditions associated with large and small-sized circulating platelets [12]. MPV is linked to cardiometabolic risk factors such as obesity, hypercholesterolemia, diabetes, hypertension and arterial stiffness [13][14][15][16][17]. Moreover, several studies have shown that elevated MPV is associated with the risk of cardiovascular disease such as myocardial infarction, stroke, and peripheral artery disease [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of mean platelet volume (MPV) levels in brucellosis patients

Kader¹,

Yolcu²,

Erbay³

2013

CMJ

View full text Add to dashboard Cite

Aim. Brucellosis is a multisystemic infectious disease. An inflammatory process occurs in brucellosis which causes increase in acute phase reactants. Mean platelet volume (MPV) has been shown as an inflammatory marker in some diseases. In this study we searched the MPV levels of brucellosis patients. Method. MPV levels of forty-seven patients with brucellosis were evaluated. Results. We included a total of 47 brucellosis patients having an average age of 47.4±14.6 and sex distribution of 21 (44,7%) male and 26 (55,3%) female and also 47 control healthy subjects having an average age of 45,2±12,3 and sex distribution of 25 (53,2%) male and 22 (46,8%) female). Erythrocte sedimentation rate (ESR), MPV, red cell distribution width (RDW), Hemoglobin (Hgb) and white blood cell(WBC) values in pre-treatment stage were statistically different from after treatment period. MPV levels were significantly lower in the pretreatment group. Similarly RDW values were lower in pretreatment group. MPV levels of patients were not diffrent in the acute and subacute stage. There was not any significant difference in the MPV levels of patients with hepatomegaly and without hepatomegaly (MPV levels of patients with splenomegaly were lower than patients without splenomegaly Spearman's correlation analysis showed a significant negative correlation between STAT (serum tube agglutination test) and MPV values. Conclusion. MPV levels may be useful in the follow-up of brucellosis patients.

show abstract

“…It has also been shown that obesity, some antihypertensive drugs, and statin use can increase MPV values. [5][6][7] In Table 1, there are 20 patients with hypertension in the patient group and 10 patients with hypertension in the control group. However, there are no data about drugs used in these patients and controls.…”

mentioning

confidence: 99%

Mean Platelet Volume Measurement in Patients With Hypercholesterolemia

Varol

Özaydın

2013

Angiology

View full text Add to dashboard Cite

We read the article by Akin et al with great interest. 1 They reported that patients with hypercholesterolemia have significantly higher mean platelet volume (MPV) than controls, suggesting higher platelet activity. They also showed that atorvastatin treatment produced a significant decrease in MPV levels and platelet count. This is an interesting and important study. However, we want to make some minor criticisms about this study.In Methods section, the authors 1 did not mention the tube that the blood sample was collected for whole blood count. This is very important. The MPV increases over time in EDTA-anticoagulated samples, and this increase was shown to be proportional with the delay in time between sample collection and laboratory analysis. With impedance counting, the MPV increases over time as platelets swell in EDTA, with increases of 7.9% within 30 minutes having been reported and an overall increase of 13.4% over 24 hours, although the majority of this increase occurs within the first 6 hours. 2 The recommended optimal measuring time of MPV is 120 minutes after venipuncture. 3 For reliable MPV measurement, the potential influence of anticoagulant on the MPV must be carefully controlled, either using an alternative anticoagulant (such as citrate) or standardizing the time delay between sampling and analysis (<2 hours).Second, there are significant associations of MPV with diabetes mellitus, prediabetes, hypertension, hypercholesterolemia, obesity, metabolic syndrome, statin and some antihypertensive use, and atrial fibrillation. 4 These factors can influence the MPV values. Although the authors 1 excluded some chronic diseases, data of cardiovascular diseases including coronary artery disease, body mass index, antihypertensive drugs, and statin use are lacking. The mean age of the patients is 56 years old, and some of them may have cardiovascular disease at this age. It has also been shown that obesity, some antihypertensive drugs, and statin use can increase MPV values. [5][6][7] In Table 1, there are 20 patients with hypertension in the patient group and 10 patients with hypertension in the control group. However, there are no data about drugs used in these patients and controls. We believe that, it would be useful if the authors provided data about these risk factors and their possible relationship with MPV and hypercholesterolemia.

show abstract

Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy

Cited by 121 publications

References 14 publications

Increased mean platelet volume in type 2 diabetes mellitus

Increased mean platelet volume in type 2 diabetes mellitus

Evaluation of mean platelet volume (MPV) levels in brucellosis patients

Mean Platelet Volume Measurement in Patients With Hypercholesterolemia

Contact Info

Product

Resources

About