Platelet membrane-coated C-TiO2 hollow nanospheres for combined sonodynamic and alkyl-radical cancer therapy

Guo, Wei; Wang, Tao; Huang, Chunyu; Ning, Shipeng; Guo, Qinglong; Zhang, Wei; Yang, Huawei; Zhu, Delan; Huang, Qinqin; Qian, Haisheng; Wang, Xianwen

doi:10.1007/s12274-022-4646-2

Cited by 39 publications

(23 citation statements)

References 50 publications

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“…HABT-C@HA TiO 2 Modulation of TME [89] TiO 2 -Fe 3 O 4 @PEG TiO 2 Modulation of TME [112] W-TiO 2 TiO 2 Modulation of TME [114] Nb 2 C/TiO 2 /BSO-PVP TiO 2 Modulation of TME [122] Pt-TiO 2 TiO 2 Modulation of TME [80] C-TiO 2 /TPZ@CM TiO 2 Modulation of TME [49] C-TiO 2 /AIPH@PM TiO 2 Modulation of TME [123] of GSH and micro-acidity of the tumor sites impede the effectiveness of single CDT. On the other hand, TiO 2 NPs also suffer from low ROS productivity owing to fast e − -h + recombination.…”

Section: Modulation Of Tme [35b]mentioning

confidence: 99%

Sonocatalytic Optimization of Titanium‐Based Therapeutic Nanomedicine

et al. 2023

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Recent considerable technological advances in ultrasound‐based treatment modality provides a magnificent prospect for scientific communities to conquer the related diseases, which is featured with remarkable tissue penetration, non‐invasive and non‐thermal characteristics. As one of the critical elements that influences treatment outcomes, titanium (Ti)‐based sonosensitizers with distinct physicochemical properties and exceptional sonodynamic efficiency have been applied extensively in the field of nanomedical applications. To date, a myriad of methodologies has been designed to manipulate the sonodynamic performance of titanium‐involved nanomedicine and further enhance the productivity of reactive oxygen species for disease treatments. In this comprehensive review, the sonocatalytic optimization of diversified Ti‐based nanoplatforms, including defect engineering, plasmon resonance modulation, heterojunction, modulating tumor microenvironment, as well as the development of synergistic therapeutic modalities is mainly focused. The state‐of‐the‐art Ti‐based nanoplatforms ranging from preparation process to the extensive medical applications are summarized and highlighted, with the goal of elaborating on future research prospects and providing a perspective on the bench‐to‐beside translation of these sonocatalytic optimization tactics. Furthermore, to spur further technological advancements in nanomedicine, the difficulties currently faced and the direction of sonocatalytic optimization of Ti‐based therapeutic nanomedicine are proposed and outlooked.

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Section: Modulation Of Tme [35b]mentioning

confidence: 99%

Sonocatalytic Optimization of Titanium‐Based Therapeutic Nanomedicine

et al. 2023

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“…6 To address this problem effectively, combining two drugs [7][8][9] in one nanocarrier is a good choice. To date, a wide variety of nanomedicines (e.g., nanozymes, 10 nanodots, 11 nanospheres, 12 gold nanostructures 13 and carbon nanoparticles 14 ) has attracted much attention from researchers. Among them, previous studies have demonstrated that nanodiamonds (NDs) have good biocompatibility and easy surface modication, 15 which make them excellent candidates for drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy

Cui,

Hu,

et al. 2023

RSC Adv.

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“…As the key of SDT, various sonosensitizers have been explored in recent years, including organic − and inorganic sonosensitizers. The commonly used organic sonosensitizers inevitably exhibited phototoxicity and low biological stability, along with short circulation time. − Although inorganic sonosensitizers can overcome these shortcomings, such as MOFs, noble metal nanoparticles, − metallic oxide, − carbon structures derived from MOFs, black phosphorus, etc., their nonbiodegradability and potential long-term side effects are still the main obstacles to limit their further application. Therefore, it is urgent to explore the biodegradable inorganic sonosensitizers.…”

Section: Introductionmentioning

confidence: 99%

A Novel Biodegradable Nanoplatform for Tumor Microenvironments Responsive Bimodal Magnetic Resonance Imaging and Sonodynamic/Ion Interference Cascade Therapy

Wang

Xue

et al. 2022

ACS Appl. Mater. Interfaces

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The unsatisfactory therapeutic effect and long-term adverse effect markedly prevent inorganic nanomaterials from clinical transformation. In light of this, we developed a novel biodegradable theranostic agent (MnCO 3 :Ho 3+ @DOX/Ca 3 (PO 4 ) 2 @BSA, HMCDB) based on the sonosensitizer manganese carbonate (MnCO 3 ) coating with calcium phosphate (Ca 3 (PO 4 ) 2 ) and simultaneously loaded it with the chemotherapeutic drug doxorubicin (DOX). Due to the mild acidity of the tumor microenvironment (TME), the Ca 3 (PO 4 ) 2 shell degraded first, releasing substantial quantities of calcium ions (Ca 2+ ) and DOX. Meanwhile, with the ultrasound (US) irradiation, MnCO 3 produced enough reactive oxygen species (ROS) to cause oxidative stress in the cells, resulting in accumulation of Ca 2+ . Consequently, the cascade effect significantly amplified the therapeutic effect. Importantly, the nanocomposite can be completely degraded and cleared from the body, demonstrating that it was a promising theranostic agent for tumor therapy. Furthermore, the doped holmium ions (Ho 3+ ) and in situ generation of manganese ions (Mn 2+ ) in TME endow the nanoagent with the ability for tumor-specific bimodality T 1 /T 2 -weighted magnetic resonance imaging (MRI). This novel nanoplatform with low toxicity and biodegradability holds great potential for cancer diagnosis and treatment.

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Platelet membrane-coated C-TiO2 hollow nanospheres for combined sonodynamic and alkyl-radical cancer therapy

Cited by 39 publications

References 50 publications

Sonocatalytic Optimization of Titanium‐Based Therapeutic Nanomedicine

Sonocatalytic Optimization of Titanium‐Based Therapeutic Nanomedicine

pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy

A Novel Biodegradable Nanoplatform for Tumor Microenvironments Responsive Bimodal Magnetic Resonance Imaging and Sonodynamic/Ion Interference Cascade Therapy

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