Platelet-membrane-camouflaged bismuth sulfide nanorods for synergistic radio-photothermal therapy against cancer

Chen, Yin; Zhao, Gaomei; Wang, Song; He, Yiliang; Han, Songling; Du, Changhong; Li, Shichao; Fan, Zheng-li; Wang, Cheng; Wang, Junping

doi:10.1039/c9bm00599d

Cited by 81 publications

(70 citation statements)

References 53 publications

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“…7a). Consistent with that PM cloaking improves the therapeutic e cacy of mesoporous silica-coated bismuth nanorod as we recently described [4], PINPs@PM was superior to PINPs at decreasing the tumor volumes (Additional le 5). Due to the enhancement to tumor targeting, irradiation pretreatment further improved the curative effect of PINPs@PM, as revealed by the signi cantly lowered tumor sizes in both volume (Fig.…”

Section: Tumor Targeting and Therapeutic Assessment In Vivosupporting

confidence: 84%

“…Platelets have pathophysiological affnity with tumors [20]. The interaction between P-selectin and CD44 partially contributes to the binding of PM-camou aged nanomaterials to the surface of breast cancer cells [4,21]. After aggregation on the cell membrane, our data showed that PINPs@PM was endocytosed by 4T1 cells in a time-dependent manner.…”

Section: Effect Of Irradiation On the Endocytosis Of Pinps@pm By Cancmentioning

confidence: 72%

“…PM camou age was performed as we recently described [4]. Mouse platelets were collected by gradient centrifugation, frozen at -80 °C and thawed at room temperature.…”

Section: Preparation Of Pinps and Pinps@pmmentioning

confidence: 99%

“…Compared with the passive targeting phenomenon, which is mostly based on the enhanced permeability and retention effect and is limited by tumor types [11,12], the active targeting method, such as modifying TNPs with peptides and antibodies [13,14], is more e cient to promote drug accumulation in tumors. Notably, due to the presence of functional molecules with high a nity to cancer cells on certain cell membranes, P-selectin on the platelet membrane (PM) [4], for example, some CMBNPs possess an active tumor targeting capability. Further decoration of the cell membrane with tumor necrosis factor-related apoptosis-inducing ligand can strengthen the targeting ability [15], but the process is somewhat complex.…”

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confidence: 99%

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Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles

Chen

Shen

Han

et al. 2020

Preprint

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Backgroud: Cell membrane-based nanocarriers are promising candidates for delivering antitumor agents. The employment of a simple and feasible method to improve the tumor-targeting abilities of these systems is appealing for further application. Herein, we prepared a platelet membrane (PM)-camouflaged antitumor nanoparticle. The effects of irradiation pretreatment on tumor targeting of the nanomaterial and on its antitumor action were evaluated. Results: The biomimetic nanomaterial constructed by indocyanine green, poly(d,l-lactide-co-glycolide), and PM is termed PINPs@PM. A 4-Gy X-ray irradiation increased the proportions of G2/M phase and Caveolin-1 content in 4T1 breast cancer cells, contributing to an endocytic enhancement of PINPs@PM. PINPs@PM produced hyperthermia and reactive oxygen species upon excitation by near-infrared irradiation, which were detrimental to the cytoplasmic lysosome and resulted in cell death. Irradiation pretreatment thus strengthened the antitumor activity of PINPs@PM in vitro. Mice experiments revealed that irradiation enhanced the tumor targeting capability of PINPs@PM in vivo. When the same dose of PINPs@PM was intravenously administered, irradiated mice had a better outcome than did mice without X-ray pretreatment. Conclusion: The study demonstrates an effective strategy combining irradiation pretreatment and PM camouflage to deliver antitumor nanoparticles, which may be instrumental for targeted tumor therapy.

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Section: Tumor Targeting and Therapeutic Assessment In Vivosupporting

confidence: 84%

Section: Effect Of Irradiation On the Endocytosis Of Pinps@pm By Cancmentioning

confidence: 72%

“…PM camou age was performed as we recently described [4]. Mouse platelets were collected by gradient centrifugation, frozen at -80 °C and thawed at room temperature.…”

Section: Preparation Of Pinps and Pinps@pmmentioning

confidence: 99%

mentioning

confidence: 99%

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Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles

Chen

Shen

Han

et al. 2020

Preprint

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“…Taking the advantage of functional elements on human platelet membranes, we have developed some CMBNPs with the capabilities of tumor targeting and immune escape. [12][13] In this study, we selected the membrane of human embryonic kidney-239T cells highly expressing human ACE2 (HEK-293T-hACE2) to prepare CMBNPs after analyzing the ACE2 content in five human cells ( Figure 1). The antiviral activity and mechanism of action of this nanomaterial were investigated by pseudovirus neutralization assay, spike adhesion experiment, and proteomics analysis.…”

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confidence: 99%

Membrane Nanoparticles Derived from ACE2-rich Cells Block SARS-CoV-2 Infection

Wang

Chen

et al. 2020

Preprint

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The ongoing COVID-19 epidemic worldwide necessitates the development of novel effective agents against SARS-CoV-2. ACE2 is the main receptor of SARS-CoV-2 S1 protein and mediates viral entry into host cells. Herein, the membrane nanoparticles prepared from ACE2-rich cells are discovered with potent capacity to block SARS-CoV-2 infection. The membrane of human embryonic kidney-239T cell highly expressing ACE2 is screened to prepare nanoparticles. The nanomaterial termed HEK-293T-hACE2 NPs contains 265.1 ng mg−1 of ACE2 on the surface and acts as a bait to trap SARS-CoV-2 S1 in a dose-dependent manner, resulting in reduced recruitment of the viral ligand to host cells. Interestingly, SARS-CoV-2 S1 can translocate to the cytoplasm and affect the cell metabolism, which is also inhibited by HEK-293T-hACE2 NPs. Further studies reveal that HEK-293T-hACE2 NPs can efficiently suppress SARS-CoV-2 S pseudovirions entry into human proximal tubular cells and block viral infection with a low half maximal inhibitory concentration. Additionally, this biocompatible membrane nanomaterial is sufficient to block the adherence of SARS-CoV-2 D614G-S1 mutant to sensitive cells. Our study demonstrates a easy-to-acheive memrbane nano-antagonist for curbing SARS-CoV-2, which enriches the existing antiviral arsenal and provides new possibilities to treat COVID-19. Graphical Table of Contents

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Nanobiomimetic Medicine

Chang

Dong

Huang

et al. 2022

Adv Funct Materials

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The application of nanotechnology in medicine aims at developing the precise theranostics of diseases by leveraging the extraordinary effects of engineered nanomedicines, materdicine, and biomaterials. However, finely controlling the biological behavior of nanomaterials in the complex living systems remains a great challenge in terms of accuracy and intelligence. Inspired by nature, biomimetics has become an attractive strategy based on the highly ordered natural biological structure for the development of clinically valuable materials and technologies, arising from the superior bioavailability. The rapid development of biomimetics in nanomedical applications prompts the authors to propose the concept of “nanobiomimetic medicine”, which is a considerable subdiscipline in nanomedicine and materdicine that applies the concept and strategies of biomimetics to facilitate and promote the disease theranostics. Herein, the authors aim to furnish a state‐of‐the‐art review on the latest progress in the field of nanobiomimetic medicine. The design strategies, structural features and biological properties of biomimetic materials are initially introduced to reveal the inherent bionic mechanism and the potential structure‐function relationships. Furthermore, advances with respect to the applications of diverse biomimetic materials are comprehensively summarized. Finally, the current challenges and future direction of nanobiomimetic medicine are discussed and prospected in order to stimulate more biomimetic fundamental and technological breakthroughs in nanomedicine.

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Platelet-membrane-camouflaged bismuth sulfide nanorods for synergistic radio-photothermal therapy against cancer

Abstract: Autologous platelet membrane camouflage improves the bioavailability of mesoporous silica-coated bismuth sulfide nanorods in tumor radio-photothermal synergistic therapy.

Cited by 81 publications

References 53 publications

Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles

Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles

Membrane Nanoparticles Derived from ACE2-rich Cells Block SARS-CoV-2 Infection

Nanobiomimetic Medicine

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