Platelet Lysate as a Promising Medium for Nanocarriers in the Management and Treatment of Ocular Diseases

Balaji, Sai A.; Karthikeyan, Ramadoss; Kiran, V.; Yuvaraj, B.; Nagaraj, Saraswathi; Manivannan, Sivakami; Narayan, Shoba

doi:10.1007/s40135-022-00285-5

Cited by 3 publications

(1 citation statement)

References 207 publications

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“…Nanotherapeutics overcome the limitations and reduce side effects by their high specificity, biocompatibility, enhanced permeability retention, and increased host immunological response [12]. There are several nanodrug delivery systems available [13,14]. This delivery system (i) can incorporate both hydrophobic and hydrophilic drugs, (ii) can be administered through any route like nasal, ocular, oral, etc., (iii) increases the shelf life of drugs, and (iv) improves drug bioavailability [15].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Role of Nano-Formulated Red Algae Extract in Cancer Management

Janani,

Girigoswami,

Deepika

et al. 2024

Molecules

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Cancer is one of the major causes of death, and its negative impact continues to rise globally. Chemotherapy, which is the most common therapy, has several limitations due to its tremendous side effects. Therefore, developing an alternate therapeutic agent with high biocompatibility is indeed needed. The anti-oxidative effects and bioactivities of several different crude extracts of marine algae have been evaluated both in vitro and in vivo. In the present study, we synthesized the aqueous extract (HA) from the marine algae Amphiroa anceps, and then, a liposome was formulated for that extract (NHA). The extracts were characterized using different photophysical tools like dynamic light scattering, UV–visible spectroscopy, FTIR, scanning electron microscopy, and GC-MS analysis. The SEM image revealed a size range of 112–185 nm for NHA and the GC-MS results showed the presence of octadecanoic acid and n-Hexadecanoic acid in the majority. The anticancer activity was studied using A549 cells, and the NHA inhibited the cancer cells dose-dependently, with the highest killing of 92% at 100 μg/mL. The in vivo studies in the zebrafish model showed that neither the HA nor NHA of Amphiroa anceps showed any teratogenic effect. The outcome of our study showed that NHA can be a potential drug candidate for inhibiting cancer with good biocompatibility up to a dose of 100 μg/mL.

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Section: Introductionmentioning

confidence: 99%

Unveiling the Role of Nano-Formulated Red Algae Extract in Cancer Management

Janani,

Girigoswami,

Deepika

et al. 2024

Molecules

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Anti-oxidant and Anti-ageing Mechanism of Bioactive Compounds in Modulating the Ageing-Related Epigenetic Factors

Das

Dey

Duttaroy

et al. 2023

Evidence-Based Functional Foods for Prevention of Age-Related Diseases

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Nanotechnology in Smart Contact Lenses: Highlights on Sensor Technologies and Future Prospects

2023

CNM

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The eye is a complex organ in the body containing a repertoire of metabolite indicators such as glucose, peptides, specialized ions, and many critical biological data such as intraocular pressure (IOP), corneal temperature, and pH. Contact lens research and patient care have progressed substantially throughout the last three decades; hence smart contact lenses were developed with significant advancements in material biocompatibility, better lens layouts, the healthcare system, and more flexible and efficient modalities. Smart contact lenses are adjustable sophisticated visual prosthesis devices that monitor various significant physical and biochemical changes in ocular disorders, which are noninvasive and continuous. Wearable systems that utilize bodily fluids like sweat tears, saliva, and electrochemical interactions with steady physiological state and illness monitoring are currently developing. Because of its ease of access, fabrication, and noninvasiveness, tear fluid is commonly used to assess ocular disorders, blood glucose, and even cancers. Furthermore, the integration of nanotechnology into contact lenses has emerged as a promising platform for noninvasive point-of-care diagnostics. Utilizing nano-based contact lenses for ocular drug delivery is a new study area in bioengineering and innovative medical techniques. Despite all of the research done in this area, new technologies are still in their early stages of development, and more work in terms of clinical trials is required to commercialize nanotechnology-based contact lenses. This article encompasses nanotechnology-based smart contact lens technology, including materials, advancements, applications, sensor technologies, and prospects.

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Platelet Lysate as a Promising Medium for Nanocarriers in the Management and Treatment of Ocular Diseases

Cited by 3 publications

References 207 publications

Unveiling the Role of Nano-Formulated Red Algae Extract in Cancer Management

Unveiling the Role of Nano-Formulated Red Algae Extract in Cancer Management

Anti-oxidant and Anti-ageing Mechanism of Bioactive Compounds in Modulating the Ageing-Related Epigenetic Factors

Nanotechnology in Smart Contact Lenses: Highlights on Sensor Technologies and Future Prospects

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