2019
DOI: 10.1172/jci.insight.129270
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Platelet IP6K1 regulates neutrophil extracellular trap-microparticle complex formation in acute pancreatitis

Abstract: IP6K1 is a novel therapeutic target in acute pancreatitis Abbreviations: (AP) acute pancreatitis; (ELISA) enzyme-linked immunosorbent assay; (IL-6) interleukin-6; (i.p.) intraperitoneal; (IP6K1) inositol hexakisphosphate kinase 1; (i.v.) intravenous; (MIP-2/CXCL2) macrophage inflammatory protein-2; (MMP-9) matrix metalloproteinase-9; (MP) microparticle; (MPO) myeloperoxidase; (NETs) neutrophil extracellular traps; (PMA) phorbol myristate acetate; (PBS) phosphate buffered saline; (PNA) platelet-neutrophil aggre… Show more

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Cited by 11 publications
(14 citation statements)
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“…Acute pancreatitis can be accompanied by severe systemic inflammation, hence there are immunological traits related to sepsis. A recent study showed that PMN-EVs associated with neutrophil extracellular traps in an animal model of acute pancreatitis contribute to both local and systemic deterioration of inflammation [ 135 ].…”
Section: Neutrophil-derived Evsmentioning
confidence: 99%
“…Acute pancreatitis can be accompanied by severe systemic inflammation, hence there are immunological traits related to sepsis. A recent study showed that PMN-EVs associated with neutrophil extracellular traps in an animal model of acute pancreatitis contribute to both local and systemic deterioration of inflammation [ 135 ].…”
Section: Neutrophil-derived Evsmentioning
confidence: 99%
“…Thrombin stimulation of IP6K1-deficient platelets in the presence of neutrophils results in no NET formation. NET formation induced by taurocholate reduced pancreatic inflammation and tissue damage in IP6K1-deficient mice (Madhi et al, 2019 ). Therefore, NETs play a role in mediating inflammation and thrombosis, bridging the transition between hypercoagulability and severe inflammation in the early pathophysiology of pancreatitis.…”
Section: The Proteins In Neutrophil Granules In Acute Pancreatitismentioning
confidence: 99%
“…NETs were initially thought to be a mechanism by which neutrophils clear pathogens, for example, the replication of staphylococcus aureus, salmonella typhimurium, streptococcus pneumoniae, and shigella flexneri can be inhibited by NETs 30 , 33 - 35 . But its critical role in sterile inflammation has also been revealed in recent years, such as deep venous thrombosis 36 , lung cancer 37 , arthritis 38 , AP 25 , 39 , 40 , endogenous particulate-related injury 41 , glioma 31 , liver ischemia-reperfusion injury 42 , ischemic stroke 43 , etc.…”
Section: Neutrophilsmentioning
confidence: 99%
“…A substantial number of studies have suggested that neutrophils are involved in the pathogenesis of AP 25 , 27 , 28 , 39 , 40 , 47 - 76 ( Figure 2 ). Measurements of MPO levels in serum 27 or pancreatic tissue 49 , 54 , 61 can reflect the number and activity of infiltrating neutrophils.…”
Section: Neutrophilsmentioning
confidence: 99%
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