The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis

Wan, Jianhua; Ren, Yuping; Yang, Xiaoyu; Li, Xueyang; Xia, Liang; Lü, Nonghua

doi:10.3389/fcell.2020.565758

Cited by 36 publications

(46 citation statements)

References 84 publications

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“…Neutrophils and macrophages also play a key role in both the local as well as systemic inflammatory response in acute pancreatitis 139,140 . Neutrophil invasion into the pancreas is suspected to occur due to the release of CXC ligand 2 (CXCL2) and other chemoattractants in early AP 141,142 .…”

Section: Pathogenesis Of Acute Pancreatitismentioning

confidence: 99%

“…Neutrophils and macrophages also play a key role in both the local as well as systemic inflammatory response in acute pancreatitis. 139,140 Neutrophil invasion into the pancreas is suspected to occur due to the release of CXC ligand 2 (CXCL2) and other chemoattractants in early AP. 141,142 Experimental depletion of neutrophils results in reduced pancreatic injury and increased survival, highlighting the critical nature of neutrophils in disease pathogenesis.…”

Section: Pathogenesis Of Acute Pancreatitismentioning

confidence: 99%

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New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

Cridge

Lim

Algül

et al. 2022

Veterinary Internal Medicne

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While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors for pancreatitis in dogs, allowing for improved awareness and detection of potential dog‐specific risk factors, which might guide the development of disease prevention strategies. Additionally, we review important advances in our understanding of the pathophysiology of pancreatitis and potential areas for therapeutic manipulation based thereof. The outcome of pathophysiologic mechanisms and the development of clinical disease is dependent on the balance between stressors and protective mechanisms, which can be evaluated using the critical threshold theory.

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Section: Pathogenesis Of Acute Pancreatitismentioning

confidence: 99%

Section: Pathogenesis Of Acute Pancreatitismentioning

confidence: 99%

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

Cridge

Lim

Algül

et al. 2022

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Thus, IL-17A may amplify the inflammatory cascade during AP by recruiting neutrophils and macrophages to the damaged area, contributing to the severity of AP. Neutrophil extracellular traps (NETs), the second bactericidal mechanism of neutrophils, promotes pancreatic tissue injury and plays key role in the pathophysiological mechanisms of AP ( 57 ). IL-17 could enhance reactive oxygen species concentrations and NETs production in neutrophils during AP ( 58 ).…”

Section: The Role Of Il-17 In Apmentioning

confidence: 99%

Role of Interleukin-17 in Acute Pancreatitis

Chen

Liu

et al. 2021

Front. Immunol.

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Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by systemic manifestations that are generally associated with a poor prognosis. Many cytokines contribute to pancreatic tissue damage and cause systemic injury. Interleukin-17 (IL-17) is a cytokine that may play a vital role in AP. Specifically, IL-17 has important effects on the immune response and causes interactions between different inflammatory mediators in the AP-related microenvironment. In this literature review, we will discuss the existing academic understanding of IL-17 and the impacts of IL-17 in different cells (especially in acinar cells and immune system cells) in AP pathogenesis. The clinical significance and potential mechanisms of IL-17 on AP deterioration are emphasized. The evidence suggests that inhibiting the IL-17 cytokine family could alleviate the pathogenic process of AP, and we highlight therapeutic strategies that directly or indirectly target IL-17 cytokines in acute pancreatitis.

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“…NETs have been implicated in many gastrointestinal diseases including inflammatory bowel diseases (IBDs) [ 39 , 40 , 41 ], liver disease [ 35 ], and acute pancreatitis [ 42 , 43 , 44 ]. A chronic abiding repetitive event of inflammation in intestinal epithelium is portrayed as IBD [ 39 ].…”

Section: Nets In Gastrointestinal Inflammationmentioning

confidence: 99%

Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis

Khan

Chowdhury

Billah

et al. 2021

IJMS

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Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.

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The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis

Cited by 36 publications

References 84 publications

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

Role of Interleukin-17 in Acute Pancreatitis

Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis

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