Platelet-induced suppression of baroreceptor activity is mediated by a stable diffusible factor

Li, Zhi; Chapleau, Mark W.

doi:10.1016/0165-1838(95)80007-w

Cited by 9 publications

(9 citation statements)

References 23 publications

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“…Besides, it should be noted that sBRS is a composite marker of the overall integrity of the autonomic nervous system and is therefore determined by additional factors other than arterial stiffness, such as the parasympathetic and sympathetic nervous system function, paracrine factors, 29 oxygen free radicals, 30 and platelet aggregation. 31 Since, currently, there are no available studies investigating such a possible correlation between arterial stiffness and carotid plaque echogenicity, no safe conclusions can be drawn regarding this issue.…”

Section: Discussionmentioning

confidence: 98%

The role of carotid plaque echogenicity in baroreflex sensitivity

Tsekouras

Katsargyris

Skrapari

et al. 2011

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 98%

The role of carotid plaque echogenicity in baroreflex sensitivity

Tsekouras

Katsargyris

Skrapari

et al. 2011

Journal of Vascular Surgery

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“…Increased sympathoadrenergic activity and withdrawal of vagal activity may contribute to enhanced platelet aggregation through catecholamine stimulation. The factors released from aggregating platelets may also impair baroreflex function, probably by modulation of peripheral sensory baroreceptive neurons [17,20] and vascular function [5]. In addition, a significant positive correlation between platelet count and platelet thromboxane production was previously observed in normal subjects [28] and patients with essential thrombocythemia [27].…”

Section: Determinants Of Brsmentioning

confidence: 93%

“…Functional mechanisms at the level of the peripheral sensory endings contribute significantly to altered baroreflex responses [2]. Isolated platelets activated with thrombin profoundly suppress baroreceptor activity recorded from the whole carotid sinus nerve and factors released from aggregating platelets are involved in this inhibitory activity [17,20]. In addition, platelet factors such as thromboxane and prostaglandins, such as prostacyclin, are important regulators of vascular function [5].…”

Section: Determinants Of Brsmentioning

confidence: 99%

Influence of coronary artery disease risk factors on baroreflex sensitivity in the elderly

Yasumasu

Takahara

Sadayasu

et al. 2003

Clinical Autonomic Research

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In this study, we assessed whether baroreflex sensitivity (BRS) is influenced by risk factors of cardiovascular disease. Subjects of this study were 95 elderly people (40 males and 55 females; mean age +/- SD, 66.6+/-1.6 years) who underwent a medical check-up. BRS was determined as the gain of transfer function in baroreflex arc by spectral analysis of mean blood pressure and R-R interval variabilities in low-frequency band (0.04-0.15 Hz). Gender-related differences in BRS and relationships between BRS and various risk factors of cardiovascular disease were investigated. The value of BRS was significantly higher in males [10.7+/-3.7 (SD) ms/mmHg] than in females [9.0+/-4.0 ms/mmHg, p< 0.05]. However, this gender-related difference disappeared when other variables were taken into account in the multivariate model. Multiple regression analyses showed independent inverse relationships between BRS and heart rate [b=-0.016+/-0.004 (SE) bpm, beta=-0.39], and between BRS and platelet count [b=-0.002+/-0.001 x 103/ micro l, beta=-0.22]. Our results indicated that BRS is inversely related to platelet count in the elderly population. The precise mechanism of this correlation is unknown, but platelet factors released from platelet aggregates can potentially influence vascular function and modify BRS, or there is a common underlying determinant responsible for the covariation.

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“…Continued exposure of carotid sinus to platelets markedly decreases BRS over 10-15 minutes [17][18][19]. The decrease in BRS is not related to changes in carotid compliance, and is mediated by an unidentified diffusible factor released from platelets [17][18][19][20].…”

Section: From Correlates To Causalitymentioning

confidence: 96%

“…These sites of activation position the activated platelets near baroreceptor and cardiac receptor nerve endings in carotid sinus and heart. Consequently, experimental studies have focused on these sensory nerves as possible sites of action of platelet factors [5,6,[17][18][19][20].…”

Section: From Correlates To Causalitymentioning

confidence: 99%

Determinants of baroreflex sensitivity in health and disease:

Chapleau

2003

Clinical Autonomic Research

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The baroreflex is a powerful blood pressure regulatory mechanism [1,10]. Baroreceptor nerve endings detect changes in blood pressure and evoke reflex circulatory adjustments that buffer the changes in pressure. By providing moment-to-moment, negative-feedback regulation of blood pressure, the baroreflex reduces blood pressure variability and its adverse consequences.Interest in measuring baroreflex sensitivity (BRS) in human populations is surging [7-9, 11-14, 21, 29]. The increased interest relates, in part, to the now widely recognized association between decreased BRS for control of heart rate and increased risk of arrhythmias and sudden cardiac death in certain pathological states including myocardial infarction [2, 3, 13-15], heart failure [21,22], and possibly diabetes [16]. A large multi-center prospective trial (ATRAMI) recently demonstrated that measures of BRS provide independent prognostic value in predicting total cardiac and arrhythmic mortality after myocardial infarction [13,14]. Attempts are now underway to identify optimal predictors of decreased BRS in healthy subjects [7,8,11] and in patients prior to myocardial infarction or heart failure [9,12].The goal of the study by Yasumasu and colleagues reported in this issue of Clinical Autonomic Research [29], was to identify risk factors of cardiovascular disease that are associated with decreased BRS. The study population was restricted to elderly subjects (40 men and 55 women, 65-69 years old) to take advantage of the prevalence of risk factors in this population and to eliminate the established and possibly confounding effect of age on BRS. BRS was calculated as the transfer function gain between low-frequency fluctuations in R-R interval and mean arterial pressure. Stepwise multiple regression analysis identified only two independent predictors of BRS in this population: heart rate and blood platelet count. These factors together accounted for approximately 20 % of the inter-individual variation in BRS. The finding of an inverse relationship between heart rate and BRS confirms previous studies [8,12].The major new finding of this study is the association of higher platelet counts (within the normal range) with low BRS. The relationship is intriguing given that platelet count in healthy middle-aged men has been shown to be an independent predictor of cardiovascular mortality [28], and that decreased BRS predicts mortality in patients with myocardial infarction [3,[13][14][15].Is platelet count simply a correlate or a cause of decreased BRS?The study by Yasumasu et al. [29] demonstrates an association between platelet count and BRS, but cannot determine causality. Although the inverse relationship between platelet count and BRS may involve an effect of platelets on BRS, platelet count may also simply be a marker of an unidentified determinant of BRS.The authors speculate that factors released from ag-CAR 131

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Platelet-induced suppression of baroreceptor activity is mediated by a stable diffusible factor

Cited by 9 publications

References 23 publications

The role of carotid plaque echogenicity in baroreflex sensitivity

The role of carotid plaque echogenicity in baroreflex sensitivity

Influence of coronary artery disease risk factors on baroreflex sensitivity in the elderly

Determinants of baroreflex sensitivity in health and disease:

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