Platelet indices in late preterm newborns

Wasiluk, Alicja; Polewko, Agnieszka; Laudański, Piotr; Redźko, S; Kicel-Wesolowska, Barbara; Dabrowska, Milena; Milewski, Robert

doi:10.1080/14767058.2016.1222519

Cited by 4 publications

(8 citation statements)

References 18 publications

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“…This large cohort showed no differences in platelet parameters at birth between late preterm and term neonates. Previous reports indicated that PLT and PCT were lower in late preterm neonates compared with term neonates [12,17]. Furthermore, they suggested that GA was significantly correlated with PLT, however, in our study, GA did not correlate with PLT [12].…”

Section: Discussioncontrasting

confidence: 96%

“…Previous reports indicated that PLT and PCT were lower in late preterm neonates compared with term neonates [12,17]. Furthermore, they suggested that GA was significantly correlated with PLT, however, in our study, GA did not correlate with PLT [12]. Instead, there was positive correlation between BW and PLT in late preterm neonates by univariate analysis.…”

Section: Discussioncontrasting

confidence: 96%

“…On the other hand, Alicja et al reported decreased PCT and PLT in late preterm neonates compared with term neonates [12]. However, few studies have addressed whether perinatal factors may be associated with platelet parameters (PCT, PLT, MPV and PDW) at birth in a large cohort of late preterm and term neonates.…”

Section: Introductionmentioning

confidence: 99%

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Perinatal factors affecting platelet parameters in late preterm and term neonates

Ohto

Nollet

et al. 2020

PLoS ONE

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Platelets parameters including platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) are associated with various physiological and pathological functions in various disease. However, few studies have addressed whether perinatal factors may be associated with platelet parameters at birth in a large cohort of late preterm and term neonates. The aim of this study to investigate perinatal factors affecting platelet parameters in late preterm and term neonates. We retrospectively investigated platelet parameters including PLT, PCT, MPV, and PDW on the first day of life in 142 late preterm and 258 term neonates admitted to our NICU from 2006 through 2020. PLT, MPV, PCT, PDW on Day 0 did not significantly differ between the two groups. In term neonates, multivariate analysis revealed that PCT correlated with being small for gestational age (SGA) (β = -0.168, P = 0.006), pregnancy induced hypertension (PIH) (β = -0.135, P = 0.026) and male sex (β = -0.185, P = 0.002). PLT was associated with SGA (β = -0.186, P = 0.002), PIH (β = -0.137, P = 0.024) and male sex (β = -0.166, P = 0.006). In late preterm neonates, multivariate analysis revealed that PLT were associated with PIH, whereas no factors associated with PDW and MPV were found. In all patients studied, chorioamnionitis (CAM) was significantly associated with MPV (CAM = 10.3 fL vs. no CAM = 9.7 fL, P<0.001). Multivariate analysis showed that SGA, male sex and PIH were associated with PCT and PLT. This study demonstrates that different maternal and neonatal complications affect platelet parameters in late preterm and term neonates.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussioncontrasting

confidence: 96%

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Perinatal factors affecting platelet parameters in late preterm and term neonates

Ohto

Nollet

et al. 2020

PLoS ONE

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“…[10] A recent study showed reduced PLT and PCT in LPN compared with term newborns (TN). [11] However, studies regarding the impact of perinatal conditions on platelet indices in late preterm and term newborns are limited. Additionally, some studies have found that maternal complications including prolonged rupture of membrane (PROM) and maternal hypertension (HT) can affect platelet indices.…”

Section: Introductionmentioning

confidence: 99%

Effect of perinatal factors on platelet indices in late preterm and term newborns

Üstün

2021

Journal of Contemporary Medicine

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This study aimed to compare platelet indices between late preterm and term newborns, and to analyze their relationship with perinatal conditions. Material and Method: Ninety-eight late preterm and 102 term newborns admitted to the neonatal intensive care unit between 2018 and 2020 were retrospectively evaluated. Platelet indices including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) were measured in blood samples taken on the first day of life. Results: There was no significant difference in the PLT, MPV, PCT, and PDW values between late preterm and term newborns. In late preterm newborns, multivariable analysis showed that maternal hypertension was significantly related to lower PLT (p=0.001). In term newborns, multivariable analysis showed that being small for gestational age (SGA), male sex, and maternal hypertension were significantly related to lower PLT (p<0.001, p=0.001 and p=0.017, respectively). In addition, SGA and male sex were related to lower PCT (p=0.001). In all studied patients, MPV was significantly different between infants with and without prolonged rupture of membrane (PROM) (9.8 fL vs. 9.2 fL, p=0.001). Conclusion:The obtained results show that various perinatal features influence the platelet indices in late preterm and term newborns.

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“…Large-scale study presented that platelet counts of preterm neonates born before 35 weeks gestation were signiicantly lower than those that were of late-preterm and preterm infants [23]. Wasiluk [24] reported the platelet count is found to be decreased in preterm and latepreterm newborns. The platelet counts were increasing with completed weeks of gestation and birth weight.…”

Section: Plateletsmentioning

confidence: 99%

Reference Intervals of Platelets, Lymphocytes and Cardiac Biomarkers in Umbilical Cord Blood

Kim¹,

Hur²,

Moon³

et al. 2017

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine

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The umbilical cord blood (UCB) can be used for early detection of neonatal diseases. The UCB can be used for early detection of neonatal diseases. Establishing reference intervals is essential for appropriate interpretation of results of laboratory tests using UCB and for correct medical decisions of pediatricians and neonatologists. The use of proper reference intervals provides reliable information to pediatricians and neonatologists; thus, they could make correct medical decisions for neonates. This chapter discussed reference intervals of platelets, lymphocytes, and cardiac biomarkers in UCB according to the Clinical Laboratory Standards Institute guidelines. Except iatrogenic anemia, thrombocytopenia is the most common hematologic abnormality in neonates. Immature platelet fraction is a novel parameter to estimate megakaryopoiesis and can be useful to understand the mechanism of thrombocytopenia, platelet destruction or bone marrow failure, in neonates. Lymphocyte counts, T cell and B cell, can relect status of immune system in fetus and neonates. Especially Tregs in UCB may contribute to maintain the immune homeostasis in the feto-maternal relationship, and the presence of Tregs would be essential to prevent immune dysregulation in fetus and neonates. Congenital heart disease or defect is the most common birth defect in newborns. Cardiac biomarkers are essential to evaluate heart function and to give information of myocardial injury, necrosis, or myocardial stretch. There are no current guidelines for their routine use in children.

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Platelet indices in late preterm newborns

Cited by 4 publications

References 18 publications

Perinatal factors affecting platelet parameters in late preterm and term neonates

Perinatal factors affecting platelet parameters in late preterm and term neonates

Effect of perinatal factors on platelet indices in late preterm and term newborns

Reference Intervals of Platelets, Lymphocytes and Cardiac Biomarkers in Umbilical Cord Blood

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