Platelet indexes in relation to target organ damage in high-risk hypertensive patients

Nadar, Sunil; Blann, Andrew D.; Kamath, Sridhar; Beevers, D. G.; Lip, Gregory Y.H.

doi:10.1016/j.jacc.2004.03.067

Cited by 150 publications

(114 citation statements)

References 45 publications

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“…Soluble ICAM-1 and VCAM-1 have also been explored in the context of essential hypertension. [26][27][28][29][30][31] In this study, ICAM-1 and VCAM-1 concentrations before RSD were significantly higher in patients who responded to RSD. Shear stress and endothelial cell activation stimulate the expression of ICAM-1 and VCAM-1 during essential hypertension, suggesting that the endothelium is more activated in responders than in nonresponders, although baseline systolic BP did not significantly differ between responders and nonresponders.…”

Section: Discussionmentioning

confidence: 87%

Soluble fms-Like Tyrosine Kinase-1 and Endothelial Adhesion Molecules (Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure Reduction After Renal Sympathetic Denervation

et al. 2014

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A rterial hypertension (HT) represents a major risk factor for cardiovascular morbidity and mortality.1 HT is associated with endothelial dysfunction that aggravates progressive vascular damage and atherosclerosis.2-4 Endothelial dysfunction can be indicated by elevated serum concentrations of endothelial adhesion molecules, including intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). 5,6 These adhesion molecules play important roles in accelerating atherosclerosis by attaching inflammatory cells to the vascular endothelial wall and promoting their subsequent migration through the endothelium.The vascular endothelial growth factor and its soluble receptor fms-like tyrosine kinase-1 (sFLT-1) are also associated with endothelial dysfunction, vascular remodeling, and endothelial repair and regeneration mechanisms.7-11 Hypoxia and endothelial shear stress in HT are known to be major stimuli for sFLT-1 expression and release.12-16 Furthermore, sFLT-1 is stimulated by the vascular sympathetic nervous system and has been reported to be elevated in patients with HT. The persistence of hypertensive blood pressure (BP) in patients with resistant hypertension is partially regulated by the renal sympathetic nerve system. 17-21 Renal sympathetic denervation (RSD) is an interventional treatment option for patients who have resistant hypertension, despite optimal medical treatment. 22,23 However, RSD is not effective in ≈8% to 12% of treated patients. 22,23 Predictive parameters regarding the response or nonresponse to RSD have not yet been described.We postulated a relationship among successful RSD-related BP reduction, endothelial dysfunction, and activated endothelial cells as indicated by ICAM-1, VCAM-1, and sFLT-1, specific markers for endothelial cell activity and hypertension-related endothelial sheer stress. Therefore, the primary aim of the present study was to examine the predictive value of sFlt-1, ICAM-1, and See Editorial Commentary, pp 907-908Abstract-Renal sympathetic denervation (RSD) is a treatment option for patients with resistant arterial hypertension, but in some patients it is not successful. Predictive parameters on the success of RSD remain unknown. The angiogenic factors soluble fms-like tyrosine kinase-1 (sFLT-1), intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) are known to be associated with endothelial dysfunction, vascular remodeling, and hypertension. We evaluated whether sFLT-1, ICAM-1, and VCAM-1 are predictive markers for blood pressure reduction after RSD. Consecutive patients (n=55) undergoing renal denervation were included. Venous serum samples for measurement of sFlt-1, ICAM-1, and VCAM-1 were collected before and 6 months after RSD. A therapeutic response was defined as an office systolic blood pressure reduction of >10 mm Hg 6 months after RSD. A significant mean office systolic blood pressure reduction of 31.2 mm Hg was observed in 46 patients 6 months after RSD. Nine patients were classified as...

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Section: Discussionmentioning

confidence: 87%

Soluble fms-Like Tyrosine Kinase-1 and Endothelial Adhesion Molecules (Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure Reduction After Renal Sympathetic Denervation

et al. 2014

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“…Some studies have reported a relationship between MPV and hypertension in different patient groups. Nadar et al [15] demonstrated that hypertensive patients with target organ damage including stroke, previous MI, angina microalbuminuria/proteinuria, and left ventricular hypertrophy, had higher MPV levels than hypertensive patients without target organ damage.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives

Surgit¹,

Püşüroğlu²,

Ertürk³

et al. 2015

Eurasian J Med

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Objective: Patients with resistant hypertension are at increased risk for cardiovascular events. Mean platelet volume (MPV) is an accepted biomarker of platelet activation and considered as a risk factor for cardiovascular disease. The aim of this study was to determine whether MPV levels are higher in resistant hypertensive (RHTN) patients than in controlled hypertensive (CHTN) patients and healthy normotensive controls. Materials and Methods Results:The mean platelet volume levels were significantly higher in RHTN group than in the CHTN and normotensive groups (p<0.001). In correlation analysis office systolic and diastolic blood pressure was positively correlated with MPV. Conclusion:Our study demonstrated that MPV, as an important indicator of platelet activation, was statistically higher in RHTN patients than in CHTN and in normotensive subjects. Elevated MPV levels may help to determine a high risk group for atherosclerosis in RHTN patients. Bulgular: Dirençli hipertansif grupta ortalama trombosit hacmi kontrollü hipertansif ve normotansif gruba göre istatistiksel olarak anlamlı olarak yüksek saptanmıştır (p<0,001). Korelasyon analizinde ofis sistolik ve diastoliktansiyonları ortalama trombosit hacmiyle pozitif korelasyon göstermekteydi. KeywordsSonuç: Çalışmamızda trombosit aktivasyonunun önemli belirteci olan ortalama trombosit hacmi dirençli hipertansif hastalarda diğer gruplara gore anlamlı olarak yüksek saptanmıştır. Artmış ortalama trombosit hacminin dirençli hipertansif hastalarda atheroskleroz açısından yük-sek riskli olanları değerlendirmede kullanılabileceği düşünülmektedir.Anahtar Kelimeler: Dirençli hipertansion, ortalama trombosit hacmi, kontrollü hipertansiyon

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“…With regard to the blood coagulation factors, it has been clearly demonstrated that PB administration causes prolongation of APTT, which is dependent on vitais not observed (Bouwman et al, 1999; Mochizuki et al PCT was noted in both sexes treated with 80 mg/kg/day -cant decrease in the MPM and PMDW with no alterations in the MPV and MPC was observed in rats of both sexes treated with either dose of PB. The analysis of platelet indices indicated that the administration of PB increases the number of platelets with a small mass in the absence of platelet activation (Nadar et al, 2004). Although an increase in the PLT appears to be an associated change was observed only in females at 80 and 8.0 mg/kg/day, but it was unlikely that these changes were biologically…”

Section: Hematopoietic Toxicitymentioning

confidence: 96%

Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats

et al. 2009

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-A 4-week repeated dose oral toxicity study of phenobarbital (PB) sodium was conducted in F344 rats of both sexes at PB doses of 0.8, 8, and 80 mg/kg/day to fully elucidate its general toxicity including hematological changes. Both sexes in the 80 mg/kg/day group showed staggering gait, lacrimation, and/or sedation, which were more evident in the early stage of treatment. The body weight gain reduction in the hematocrit (Ht), hemoglobin concentration (Hb), and erythrocyte count (RBC) in both sexes at 80 mg/kg/day, which was accompanied by a decrease in the cell mean Hb (CHCM) in mature erythrocytes with an increase in unsaturated iron binding capacity. Female rats also showed reduction in the CHCM in reticulocytes, content of hemoglobin per reticulocyte, and transferrin saturation. PB prolonged the activated partial thromboplastin time and inversely increased the platelet count with no evidence of platelet activation. Well-known toxic effects of PB on the liver and thyroid were observed in a dose-dependent manner, along with altered lipid, glucose, and electrolyte metabolism. The serum levels of PB increased dose-dependently, when examined in females received 8 and 80 mg/kg/day on day 1 and 28; there were no difference in C max and AUC 0-24 values between day 1 and day 28. These results indicated that PB has the potential to elicit multiple organ toxicity including an effect on the hematopoietic system. The hematological analysis provided evidence for hypochromic anemia, plausibly caused by the impairment of iron utility.

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Platelet indexes in relation to target organ damage in high-risk hypertensive patients

Cited by 150 publications

References 45 publications

Soluble fms-Like Tyrosine Kinase-1 and Endothelial Adhesion Molecules (Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure Reduction After Renal Sympathetic Denervation

Soluble fms-Like Tyrosine Kinase-1 and Endothelial Adhesion Molecules (Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure Reduction After Renal Sympathetic Denervation

Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives

Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats

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