Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives

Surgit, Özgür; Püşüroğlu, Hamdi; Ertürk, Mehmet; Akgül, Özgür; Buturak, Ali; Akkaya, Emre; Gül, Mehmet; Uygur, Begüm; Yazan, Serkan; Eksik, Abdurrahman

doi:10.5152/eurasianjmed.2015.43

Cited by 25 publications

(26 citation statements)

References 29 publications

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“…However, the role of platelet activation in cardiovascular events has led us to speculate that it may be associated with hypertension. In fact, previous studies have found elevated MPV values in resistant hypertension 6 and non-dipper hypertension. 7 However, whether an elevated MPV can independently predict future risk for hypertension has not been noted in the literature.…”

Section: Introductionmentioning

confidence: 87%

Association between mean platelet volume and hypertension incidence

Li¹,

Zhang²,

Zhu³

et al. 2017

Hypertens Res

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Mean platelet volume (MPV) is increased in various cardiovascular diseases. We sought to determine the prognostic value of MPV for hypertension. We performed a retrospective cohort study. Baseline characteristics were measured in 9168 individuals without hypertension, and the follow-up period was 9 years. Hypertension was confirmed in 2881 participants during the followup period. When the participants were grouped according to MPV quartiles, the hazard ratio of future hypertension gradually increased across the MPV quartiles. The hazard ratios of hypertension for the II, III and IV (high) vs. I (low) quartiles of MPV were 1.13 (95% confidence interval (CI) 1.01-1.25, P = 0.027), 1.25 (95% CI 1.12-1.39, Po0.001) and 1.40 (95% CI 1.26-1.55, Po0.001), respectively. In multivariate Cox regression analysis, MPV predicted hypertension independently of age, sex, platelet count, waist circumference, drinking, systolic blood pressure and creatinine levels. The present study indicated that elevated MPV is associated with increased incidence of hypertension independent of other risk factors, which suggests that platelet activity may play a role in hypertension incidence.

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Section: Introductionmentioning

confidence: 87%

Association between mean platelet volume and hypertension incidence

Li¹,

Zhang²,

Zhu³

et al. 2017

Hypertens Res

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“…Jalur NO memliki interaksi sinergistik dengan pembentukan/degradasi nukleotida siklik dan fosforilasi protein pada trombosit dan sel otot polos, yang mengatur fungsi kardiovaskular (tonus vaskular, inhibisi agregasi trombosit serta adhesi leukosit, dan pencegahan proliferasi sel otot polos). [8][9][10] Dalam beberapa tahun terakhir, neutrofilia dan lymphocytopenia relatif terbukti menjadi prediktor independen kematian pada pasien dengan gagal jantung akut. Selain itu, rasio neutrofil-ke-limfosit (NLR) diperkenalkan sebagai penanda potensial untuk menentukan inflamasi pada gangguan jantung dan nonjantung.…”

Section: Pendahuluanunclassified

Analisis Nilai Indeks Trombosit Dan Rasio Trombosit Limfosit Sebagai Penanda Inflamasi Glomerulus Pada Penderita Hipertensi Berbagai Derajat

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2019

Medica Arteriana (Med-Art)

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Background : Hypertension is a major risk factor for early death and cardiovascular disease (CVD), which causes at least 1.1 million deaths per year in the world. Hypertension is also called The Silent Killer because it is often found without symptoms, which if left untreated and treated will cause complications such as stroke, heart and blood vessel disease, kidney disorders and others which can ultimately lead to disability or death. Endothelial dysfunction indirectly affects platelet dysfunction which can be assessed based on platelet index and platelet lymphocyte ratio. 2,6,7Method :170 Patients with hypertension are grouped into hypertensive stage groups 1, 2 and 3. Platelet index (MPV, PDW and PCT) and lymphocyte platelet ratio are calculated based on the results of routine blood tests. Data distribution was tested by Kolmogrov-Smirnov and analyzed with the corresponding data test.Results:Platelet index namely MPV in hypertensive patients was significantly different in each degree of hypertension, grade 1 (8.92 ± 1.23), degree 2 (8.99 ± 1.63) and degree 3 (11.2 ± 4.29) with a p value = 0.003. There is a weak correlation between MPV and serum creatinine ureum levels. However, PDW and RTL values only correlate with creatinine.Conclusion:There are differences in the value of MPV in patients with hypertension of various degrees. There is a correlation between the values of MPV, PDW and RTL and creatinine which indicate inflammation of the glomerulus.

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“…[19–23] Moreover, the use of antiplatelet management therapies in the high blood pressure, the platelets play a pivotal role in the pathogenesis of hypertension. [24–27] Thus, assessments of platelet indices and their bioactivity may be of vital importance for monitoring the occurrence and progression of hypertension. Asgari et al [28] used the quadratic inference functions (QIFs) to determine the factors associated with obesity from the STEPS Survey in Iran.…”

Section: Introductionmentioning

confidence: 99%