2020 DOI: 10.20944/preprints202009.0322.v1 View full text Preprint
Antonia Melero-Amor, Paola Romecín, David Iyú, David García-Bernal, Esther García Navarro, José M. Moraleda, Joaquin Garcia-Estañ, Faustino García-Candel, Noemí M. Atucha

Abstract: Aim: In the present work we have studied the role of platelets and microvesicles in patients with severe hemophilia A (HA) treated under the regimen of prophylaxis. We have analyzed whether the administration of coagulation factor FVIII modifies this hemorrhagic phenotype in a cohort of 16 patients with diagnosis of severe HA, who were on prophylactic treatment with recombinant FVIII. Methods: Blood tests were performed before (72h without FVIII, baseline sample) and after 15 minutes of FVIII infusion. As a c…

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