Platelet Function Analysis in Children with Schönlein-Henoch Syndrome

Čulić, Srđana; Jakl, Rudolf; Metličić, Vitomir; Pauković-Sekulić, Branka; Rešić, Biserka; Čulić, Viktor; Kuljiš, Dubravka; Primorac, Dragan

doi:10.1016/s0188-4409(01)00282-x

Cited by 13 publications

(7 citation statements)

References 15 publications

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“…ADP and epinephrine stimulated platelet aggregation tests were evaluated in another study conducted with 11 male and 13 female patients aged 4-12 years with HSP. It was found that block in ADP release in 58.3% of patients, severe deterioration in aggregation in 29.2 %, whereas ADP -stimulated aggregation tests were reported as normal in 8.3% of patients [13].…”

Section: Discussionmentioning

confidence: 96%

“…Although the presence of clinical conditions such as purpuric rash, hematuria, hematemesis, and melena without thrombocytopenia in patients with HSP has been attributed to the vasculitis state, there are also various publications suggesting that coagulation disorders may be present [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…The fact that platelet count, bleeding time, clotting time, prothrombin time, and activated partial thromboplastin time were normal in patients suggest that it is due to vascular cause rather than coagulation disorders [12]. However, in some studies, it has been reported that platelet functions are impaired in patients with HSP [13,14]. This study aimed to evaluate in vitro platelet aggregation and secretion tests in patients with HSP, an essential vasculitis of childhood.…”

Section: Introductionmentioning

confidence: 99%

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Impaired In-vitro Platelet Aggregation and Secretion Tests in Children with Henoch-schöenlein Purpura

Yazarli¹,

Pi²,

Dallar³

et al. 2021

Preprint

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Aim: This study aimed to investigate the in-vitro platelet aggregation and secretion tests in children patients with Henoch-schöenlein Purpura that recently referred to as Ig A vasculitis Methods: This is a cross-section study that included 55 patients with Henoch-schöenlein Purpura and 31 healthy children as a control group. Children who have a history of drug use, chronic diseases, and bleeding diseases were excluded from the study. Complete blood count, thrombocyte aggregation, and secretion tests were studied in both groups. These tests were re-evaluated in remission of the disease. Results: It was found that epinephrine-stimulated platelet aggregation and collagen, epinephrine, ristocetin, arachidonic acid, standard dose thrombin, and high dose thrombin-stimulated platelet secretion results were lower in the patients with Henoch-schöenlein Purpura compared to the healthy control group in the acute period (respectively P=0.014, 0,003; 0,003; 0,027; 0,034; 0,010; 0,049). When the values of patients with Henoch-schöenlein Purpura in the acute period and the remission of the disease were compared, collagen-stimulated platelet aggregation and epinephrine-stimulated platelet secretion values were found to be lower in patients with patients in the acute period (P= 0.016; 0.039) Conclusion: Impairment in vitro platelet aggregation and secretion tests in the patients with Henoch-schöenlein Purpura suggest that the tendency to bleeding in these patients may be due to platelet impairment function. Key Words: Henoch-schöenlein Purpura, platelet aggregation tests, platelet secretion tests, children, Ig A vasculitis. What’s already known about this topic? There is a tendency to bleeding in Henoch Shcöenlein Purpura patients, such as gastrointestinal bleeding, nonthrombocytopenic system purpura. What does this article add? It was found that impairment in-vitro platelet aggregation and secretion tests in Henoch Shcöenlein Purpura patients.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impaired In-vitro Platelet Aggregation and Secretion Tests in Children with Henoch-schöenlein Purpura

Yazarli¹,

Pi²,

Dallar³

et al. 2021

Preprint

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“…Decreased MPV is also reported previously in the active stage of inflammatory diseases such as ankylosing spondylitis, rheumatoid arthritis, Crohn's disease, and ulcerative colitis, where normal levels were acquired after the suppression of the inflammation. [11][12][13][14] Common characteristic of those is systemic inflammation. Some authors speculated that the reduced MPV could be due to the consumption or sequestration of the activated platelets during inflammation.…”

Section: Discussionmentioning

confidence: 99%

Predicting the Severity of Henoch–Schönlein Purpura: The Role of the Functional Platelet Indices

Bayrak

Nuhoğlu

2020

Online Türk Sağlık Bilimleri Dergisi

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Amacımız tanı anında saptanan kalitatif trombosit belirteçlerinin Henoch-Schönlein purpurası'ndaki (HSP) hastalık şiddeti ve gidişatının belirlenmesindeki yeterliliğinin değerlendirilmesidir. Materyal ve Metot: HSP hastası çocukların elektronik verileri tarandı. Hastalığın ciddiyeti adapte edilmiş bir klinik skorlama sistemi ile belirlendi. Tanı anındaki trombosit sayısı, ortalama trombosit hacmi (MPV), plateletkrit (PCT) ve trombosit dağılım genişliği (PDW) belirteçleri kaydedildi. Bulgular: Toplam 76 HSP hastası (ortalama yaş: 7,4±2,5 yıl, %56,5 erkek) değerlendirildi, 59 (%77,6) olguda HSP hafif ve 17 (%22,4) olguda ciddiydi. Ciddi HSP olgularında MPV belirgin olarak düşüktü (7,6±1,0 vs. 8,44±1,1, p<0,01), ancak PCT ve PDW belirteçlerinde anlamlı bir fark yoktu. Hastaların 14'ünde relaps izlendi (%18,4, 5 hafif HSP ve 9 ciddi HSP olgusu). Ciddi HSP olgularında relapsa yatkınlık daha fazlaydı (p<0,01) ve relaps olan hastalarda PDW daha düşüktü (13,2±3,1 vs. 14,8±2,4 p<0,05). Sonuç: HSP olgularında tanı anında saptanan MPV düzeyleri hafif ve ciddi hastalığın ayrımında faydalıdır. Ayrıca, düşük PDW düzeyleri relapse yatkınlığı olan HSP hastalarının ön görülmesinde yararlı olabilir.

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“…Henoch Schönlein Purpura, usually presenting with purpuric bruises, hematemesis, melena, hematochesis or hematuria may suggest platelet function disturbances. Culic et al reported abnormal aggregation curves in HSP [24]. Makay et al reported the first study investigating MPV values in HSP [25].…”

Section: Discussionmentioning

confidence: 99%

The Value of Platelet Indices in Henoch- Schonlein Purpura

Bağ¹,

Karaarslan²,

Ecevıt³

et al. 2014

Ann Paediatr Rheum

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Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood and is usually associated with thrombocytosis. Platelet indices, mean platelet volume (MPV) and platelet distribution width (PDW) have recently been described as markers of platelet activation and function. The aim of this retrospective study is to investigate the value of platelet indices in HSP. Methods: The study was conducted in 117 HSP patients diagnosed with HSP and 68 age-and sexmatched healthy controls with a retrospective design. The data for both patient and control groups were extracted from the hospital' s computerized database following approval by the local ethics commitee. Results: The mean leukocyte and platelet counts were significantly higher in HSP patients than in the control group (p<0.01), while mean MPV and PDW values did not differ in the two groups. Furthermore, the platelet indices did not differ between patients with and without multisystemic involvement. Conclusions: The results of our study suggest that platelet indices cannot be used as a laboratory markers either in diagnosis of HSP or predicting severe multisystemic disease in HSP.

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Platelet Function Analysis in Children with Schönlein-Henoch Syndrome

Cited by 13 publications

References 15 publications

Impaired In-vitro Platelet Aggregation and Secretion Tests in Children with Henoch-schöenlein Purpura

Impaired In-vitro Platelet Aggregation and Secretion Tests in Children with Henoch-schöenlein Purpura

Predicting the Severity of Henoch–Schönlein Purpura: The Role of the Functional Platelet Indices

The Value of Platelet Indices in Henoch- Schonlein Purpura

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