Platelet distribution width is a predictive marker for development of severe retinopathy of prematurity

Şahinoğlu-Keşkek, Nedime; Akkoyun, İmren; Çetinkaya, Bilin

doi:10.1038/s41433-020-01302-2

Cited by 3 publications

(15 citation statements)

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“…In the present review, studies that defined subjects with stage 2 ROP or less as cases were explicitly excluded, to avoid confusion when interpreting the results (Figure 1). However, the definition of cases still differed significantly among studies, including type I ROP, 15,18,20,22,24,27,28,33 AP-ROP, 19 or ROP requiring treatment, encompassing both type I and AP-ROP, 16,21,23,26,[29][30][31] or at least stage 3 ROP. 25,31,32 Likewise, the definition of controls differed largely, including infants without ROP, 24,25,[27][28][29][30]32,33 ROP up to stage 1, 15,18,20,22,23 ROP up to stage 2, 19,31 or infants with less severe ROP, presumably including up to stage 3 without plus disease, namely type II ROP, 16,26 or even infants with unspecified ROP stage.…”

Section: Discussionmentioning

confidence: 99%

“…However, the definition of cases still differed significantly among studies, including type I ROP, 15,18,20,22,24,27,28,33 AP-ROP, 19 or ROP requiring treatment, encompassing both type I and AP-ROP, 16,21,23,26,[29][30][31] or at least stage 3 ROP. 25,31,32 Likewise, the definition of controls differed largely, including infants without ROP, 24,25,[27][28][29][30]32,33 ROP up to stage 1, 15,18,20,22,23 ROP up to stage 2, 19,31 or infants with less severe ROP, presumably including up to stage 3 without plus disease, namely type II ROP, 16,26 or even infants with unspecified ROP stage. 21 All these variations may affect the difference in the severity of ROP between the studied groups and therefore may have an impact on the outcome of interest.…”

Section: Discussionmentioning

confidence: 99%

“…Ultimately, 19 primary studies fulfilled the eligibility criteria and were included in this review: 18 clinical studies and one study with both experimental and clinical sections. All the clinical studies were observational, of which one case series, 17 eight retrospective case-control studies with or without matching, 15,[18][19][20][21][22][23][24] eight retrospective cohort studies, 16,[25][26][27][28][29][30][31] and two prospective cohort studies. 32,33 If studies comprised three groups, 24,27,29,30,33 comparative data were only collected on cases with ROP requiring treatment and the group of infants without ROP.…”

Section: Re Sultsmentioning

confidence: 99%

“…Over the last decade, a number of primary, observational, cohort or case-control studies, were conducted to evaluate associations between platelet parameters and severe ROP. 15,16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]…”

Section: Clinical Studiesmentioning

confidence: 99%

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Association of platelet deficiency with severe retinopathy of prematurity: a review

et al. 2022

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Aim The aim of this review was to compile existing evidence on the role of platelets in the development of severe retinopathy of prematurity (ROP), highlight the strengths and weaknesses of the available studies and critically discuss the reported data. Methods A comprehensive literature search was conducted on PubMed from January 2000 to January 2022, and the reference lists of the included studies were screened manually. Results There were 19 primary studies that fulfilled the eligibility criteria. Experimental research indicated lower platelet count in mice oxygen‐induced retinopathy model compared with normoxia controls, while platelet transfusions suppressed neovascularisation. The latter finding was not consistently confirmed in clinical research, where a low platelet count, an increased number of thrombopenic episodes and of platelet transfusions have all been implicated in the development of ROP requiring treatment, either type I or aggressive posterior or both. However, existing studies exhibit significant clinical heterogeneity and present methodological limitations that imperil their reliability and validity. Conclusion Platelet deficiency has been associated with severe ROP. However, critical thresholds of platelet parameters are still unrecognised. Future research is required to determine whether platelet parameters can be predictive biomarkers for ROP requiring treatment and at what thresholds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Re Sultsmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

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Association of platelet deficiency with severe retinopathy of prematurity: a review

et al. 2022

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“…Identifying risk factors for ROP may enhance the efficacy of screening programs. Various studies have attempted to clarify the relationship between platelet counts and ROP [ 12 , 13 , 14 , 15 , 16 , 19 , 20 , 21 , 22 , 23 ] ( Table 5 ). To our best knowledge, this is the first study to document that adjusted weekly mean platelet counts over the first 6 weeks of life have no direct relationship with ROP.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Mean Platelet Counts in Preterm Infants with and without Retinopathy of Prematurity

Lim

Pheng

Tai

et al. 2021

IJERPH

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Platelets are a primary source of pro- and anti-angiogenic cytokines. However, the evidence of their role in retinopathy of prematurity (ROP) is controversial. This retrospective study aimed to compare mean weekly platelet counts between infants with and without ROP over the first 6 weeks of life. A total of 93 infants matched by gestational age and birth weight were recruited (31 with ROP, 62 without ROP). Weekly mean platelet counts and other related risk factors were documented. The repeated measure analysis of variance (ANOVA) and the repeated measure analysis of covariance (ANCOVA) were used to compare mean platelet counts over time between the two groups, with and without adjusting for confounders. We found significant differences in the weekly mean platelet counts of infants with and without ROP over the first 6 weeks of life (p = 0.002). These differences disappeared after adjusting for covariates (p = 0.489). Lower mean platelet counts in ROP infants are not directly related to ROP, but rather to the presence of other risk factors for ROP, such as culture-proven sepsis, blood transfusion and bronchopulmonary dysplasia.

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Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis

Almutairi,

Gulden,

Hundscheid

et al. 2023

Children

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Background: We aimed to conduct a systematic review and Bayesian model-averaged meta-analysis (BMA) on the association between platelet counts and severe retinopathy of prematurity (ROP). Methods: We searched for studies reporting on platelet counts (continuous variable) or thrombocytopenia (categorical variable) and severe ROP or aggressive posterior ROP (APROP). The timing of platelet counts was divided into Phase 1 (<2 weeks) and Phase 2 (around ROP treatment). BMA was used to calculate Bayes factors (BFs). The BF10 is the ratio of the probability of the data under the alternative hypothesis (H1) over the probability of the data under the null hypothesis (H0). Results: We included 21 studies. BMA showed an association between low platelet counts and severe ROP. The evidence was strong (BF10 = 13.5, 7 studies) for phase 1 and very strong (BF10 = 51.0, 9 studies) for phase 2. Thrombocytopenia (<100 × 109/L) in phase 2 was associated with severe ROP (BF10 = 28.2, 4 studies). Following adjustment for publication bias, only the association of severe ROP with thrombocytopenia remained with moderate evidence in favor of H1 (BF10 = 4.30). Conclusions: Thrombocytopenia is associated with severe ROP. However, the evidence for this association was tempered when results were adjusted for publication bias.

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Platelet distribution width is a predictive marker for development of severe retinopathy of prematurity

Cited by 3 publications

References 4 publications

Association of platelet deficiency with severe retinopathy of prematurity: a review

Association of platelet deficiency with severe retinopathy of prematurity: a review

Comparison of Mean Platelet Counts in Preterm Infants with and without Retinopathy of Prematurity

Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis

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