Comparison of Mean Platelet Counts in Preterm Infants with and without Retinopathy of Prematurity

Lim, Zi Di; Pheng, Edwin; Tai, Evelyn Li Min; Rostenberghe, Hans Van; Shatriah, Ismail

doi:10.3390/ijerph18073783

Cited by 3 publications

(7 citation statements)

References 44 publications

(31 reference statements)

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“…In our study, anemia, thrombocytopenia, blood transfusions, IVH and sepsis were independent risk factors of ROP, especially with progression to severe ROP. This is similar to studies by Pai et al .,[ 23 ] Lim et al .,[ 24 ] Pascal et al .,[ 25 ] and Chang. [ 26 ] All these factors add to the oxidative stress on the immature retina, thereby up regulating VEGF levels, which eventually leads to neovascularization.…”

Section: Discussionmentioning

confidence: 99%

Incidence, risk factors, progression, and involution in retinopathy of prematurity at a tertiary care center in South India

Deb,

Annamalai,

Muthukumar

2023

Oman J Ophthalmol

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BACKGROUND: Retinopathy of prematurity (ROP) is a vasculoproliferative disorder of immature retina, seen in preterm babies. Multiple risk factors attribute to this condition. Our aim was to correlate the role of any early neonatal surgeries with low gestational age (GA) and birth weight (BW) on preterm babies as a risk factor on the progression of ROP. METHODS: A prospective, cohort study conducted in a hospital in South India over 3 years, including 600 babies with GA <35 weeks and BW <2500 g. Babies were divided into Group A (ROP) and Group B (no ROP). Group A included A1 (severe ROP) and A2 (nonsevere ROP) based on early treatment of ROP classification. We compared various risk factors of ROP, specifically the association of any early neonatal surgery undergone by these babies, on progression of ROP. The Chi-square test, unpaired t -test, and one-way analysis of variance tests were used for the comparisons and considered statistically significant if P < 0.05. RESULTS: 28.7% babies developed ROP, with 37.6% requiring treatment (Aggressive ROP in 2.1% of babies). Low GA and BW, longer duration on ventilator, respiratory distress syndrome, apnea of prematurity, Patent Ductus Arteriosus, sepsis, anemia, thrombocytopenia, history of blood transfusion, and history of early neonatal surgery under GA were associated with babies with ROP ( P < 0.005), strongly with severe ROP. The most common surgeries undergone by the babies developing ROP were inguinal herniotomy under general anesthesia. CONCLUSION: The study predicts preterm babies undergoing early surgical interventions are at risk of progressing to severe ROP, hence warranting frequent follow-ups.

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Section: Discussionmentioning

confidence: 99%

Incidence, risk factors, progression, and involution in retinopathy of prematurity at a tertiary care center in South India

Deb,

Annamalai,

Muthukumar

2023

Oman J Ophthalmol

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“…The role of PLTs in ROP is not yet fully understood. PLTs are cytoplasmic clumps without nuclei produced by megakaryocytes and have active physiological properties that regulate neovascularization, fibrin formation and deposition ( 18 , 19 ). Studies ( 19-22 ) have shown that PLTs locally promote or inhibit angiogenesis.…”

Section: Effect Of Hematological Indicators On Ropmentioning

confidence: 99%

“…PLTs are cytoplasmic clumps without nuclei produced by megakaryocytes and have active physiological properties that regulate neovascularization, fibrin formation and deposition ( 18 , 19 ). Studies ( 19-22 ) have shown that PLTs locally promote or inhibit angiogenesis. Platelets contain granules that store regulators of angiogenesis, including VEGF and angiogenesis inhibitors (such as endothelial inhibitors), which are released, thus regulating angiogenesis ( 23 ).…”

Section: Effect Of Hematological Indicators On Ropmentioning

confidence: 99%

Progress in the study of association between hematological indicators and retinopathy of prematurity (Review)

Tang,

Zhang,

Zhang

et al. 2024

Biomed Rep

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Retinopathy of prematurity (ROP) is a retinopathy caused by abnormal proliferation of blood vessels in premature infants. It can lead to retinal detachment and, in severe cases, blindness, rendering ROP a critical condition. Advances in neonatal medicine have improved survival rates of low birth weight and low gestational age infants. However, this progress has also led to a rise in incidence of ROP. Currently, premature birth, low birth weight and high postpartum oxygen levels are independent risk factors for ROP. Other factors include mode of delivery, multiple births, anemia, blood transfusion, maternal pregnancy factors, neonatal bronchopulmonary dysplasia, use of surfactants, arterial ductus arteriosus and necrotizing enterocolitis. Laboratory indicators in premature infants such as platelet count, levels of blood glucose, inflammatory cells, lipid and hemoglobin and blood transfusion may also be associated with ROP. However, the etiology and pathogenesis of ROP are not fully understood. A number of factors may influence the onset and progression of ROP, including decreased platelet counts, decreased hemoglobin levels, increased white blood cell counts, increased blood glucose levels, and disorders of lipid metabolism. The present study reviewed the effects of platelet count, hemoglobin, blood glucose, inflammatory cells and factors, blood lipids, and plasma metabolic pathways on ROP.

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“…The search process PRISMA flow diagram is depicted in Figure S1. Of 2645 studies with potential relevance, 21 were included [6,7,9,10,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. These studies reported on 3625 infants.…”

Section: Characteristics Of the Studies And Risk Of Bias Assessmentmentioning

confidence: 99%

“…Bayesian model-averaged meta-analysis (BMA) of the association of severe ROP with platelet counts in phase 1 (A) and phase 2 (B). Hedges' g < 0 indicates lower platelet counts in the ROP group[6,7,[27][28][29][30]35,36,[39][40][41].…”

mentioning

confidence: 99%

Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis

Almutairi,

Gulden,

Hundscheid

et al. 2023

Children

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Background: We aimed to conduct a systematic review and Bayesian model-averaged meta-analysis (BMA) on the association between platelet counts and severe retinopathy of prematurity (ROP). Methods: We searched for studies reporting on platelet counts (continuous variable) or thrombocytopenia (categorical variable) and severe ROP or aggressive posterior ROP (APROP). The timing of platelet counts was divided into Phase 1 (<2 weeks) and Phase 2 (around ROP treatment). BMA was used to calculate Bayes factors (BFs). The BF10 is the ratio of the probability of the data under the alternative hypothesis (H1) over the probability of the data under the null hypothesis (H0). Results: We included 21 studies. BMA showed an association between low platelet counts and severe ROP. The evidence was strong (BF10 = 13.5, 7 studies) for phase 1 and very strong (BF10 = 51.0, 9 studies) for phase 2. Thrombocytopenia (<100 × 109/L) in phase 2 was associated with severe ROP (BF10 = 28.2, 4 studies). Following adjustment for publication bias, only the association of severe ROP with thrombocytopenia remained with moderate evidence in favor of H1 (BF10 = 4.30). Conclusions: Thrombocytopenia is associated with severe ROP. However, the evidence for this association was tempered when results were adjusted for publication bias.

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Comparison of Mean Platelet Counts in Preterm Infants with and without Retinopathy of Prematurity

Cited by 3 publications

References 44 publications

Incidence, risk factors, progression, and involution in retinopathy of prematurity at a tertiary care center in South India

Incidence, risk factors, progression, and involution in retinopathy of prematurity at a tertiary care center in South India

Progress in the study of association between hematological indicators and retinopathy of prematurity (Review)

Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis

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