Platelet-Derived Growth Factor: Structure, Function, and Roles in Normal and Transformed Cells

Deuel, Thomas F.; Tong, Benton D.; Huang, Jung San

doi:10.1016/b978-0-12-152826-3.50012-7

Cited by 49 publications

(39 citation statements)

References 75 publications

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“…Another classical α-granular mediator, PDGF, is the principal mitogen that stimulates cell division when the vessel integrity has been compromised, and it also influences the inflammation and repair by increasing the vascular tone (Berk et al 1986). PDGF exerts chemotaxis on monocytes and neutrophils (Deuel et al 1982), and it activates monocytes (Tzeng et al 1985) and neutrophils (Deuel and Huang 1984). Moreover, an attraction of smooth muscle cells and fibroblasts to low concentrations of PDGF has been described (Grotendorst et al 1981;Seppa et al 1982;Senior et al 1983).…”

Section: Mediators Of Inflammation Within Platelet Organelles α-Granulesmentioning

confidence: 97%

Platelets and inflammation

Klinger

1997

Anatomy and Embryology

183

118

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Besides their functions in the haemostatic process and in thrombus formation after an endothelial injury, blood platelets also take part in the processes of inflammation and tissue repair that follows. For this purpose, they closely collaborate with all types of leukocytes. Activated platelets secret chemotactic substances, they facilitate the binding of leukocytes to the endothelium and their subsequent extravasation, and they may influence the inflammatory responses of leukocytes in both stimulating and inhibiting ways. However, platelets themselves also contain an array of potent proinflammatory substances, and therefore they are regarded as mediator and effector cells in inflammation. Their capability to interact with bacteria, parasites, and other foreign materials is possibly a phylogenetic vestige and may explain the existence of IgE-dependent killing mechanisms of platelets. On the other hand, the connection between IgE and platelets, besides the platelet-induced eosinophil infiltration, offers a functional basis for the involvement of platelets in allergic processes, particular in the skin and the airways.

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Section: Mediators Of Inflammation Within Platelet Organelles α-Granulesmentioning

confidence: 97%

Platelets and inflammation

Klinger

1997

Anatomy and Embryology

183

118

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“…PDGF is also released from platelets during blood clotting and blood vessel endothelia at sites of injury. In addition, PDGF promotes wound healing since it is a potent mitogen of fibroblasts, glial cells and smooth muscle cells [29] and has been shown to promote the structural integrity of the vessel wall [30]. Furthermore, PDGF is associated with fibrosis formation in chronic pancreatitis transforming pancreatic stellate cells into proliferating myofibroblasts [31].…”

Section: Discussionmentioning

confidence: 99%

Portal vein cytokines in the early phase of acute experimental oedematous and necrotizing porcine pancreatitis

Meriläinen

Mäkelä

Jensen

et al. 2012

Scandinavian Journal of Gastroenterology

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“…PDGF release is tightly regulated by circulating a-macroglobulin to prevent the biologically active cytokine from entering the systemic circulation. 82 PDGF is not present in normal ACL tissues and has been shown to be present at low levels after ACL transection in a rabbit model. This finding is in contrast to a high level of PDGF present in MCL wounds after surgical transection and may partially account for the lack of clinical healing seen in ACL injuries.…”

Section: Growth Factor/cytokine-based Augmentation Of Tendon-bone Heamentioning

confidence: 97%