Portal vein cytokines in the early phase of acute experimental oedematous and necrotizing porcine pancreatitis

Meriläinen, Sanna; Mäkelä, Jyrki; Jensen, Hanna; Dahlbacka, Sebastian; Lehtonen, Siri; Karhu, Toni; Herzig, Karl‐Heinz; Kröger, Meeri; Koivukangas, Vesa; Koskenkari, Juha; Ohtonen, Pasi; Karttunen, Tuomo J.; Lehenkari, Petri; Juvonen, Tatu

doi:10.3109/00365521.2012.722675

Cited by 11 publications

(5 citation statements)

References 40 publications

(40 reference statements)

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“…The progressive tissue damage at the cellular level of pancreatic tissue is the result of the cytokines and reactive oxygen species (ROS) secreted by the inflammatory cells [3,4]. Most studies investigating the early and chronic phases of the disease have emphasized the role of B and T lymphocytes, macrophages, neutrophils, cytokines, inflammation mediators, and reactive oxygen species (ROS) [11][12][13]. For this reason, various anti-inflammatory [14,15], antioxidant [4,15,16], and immunomodulatory [17] agents have been used in experimental studies for therapeutic purposes.…”

Section: Discussionmentioning

confidence: 99%

Research into the protective effect of syringic acid in rats with induced experimental pancreatitis

Sertkaya¹

2018

Ann Clin Anal Med

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Aim: The aim of this study was to evaluate the protective effects of dietary syringic acid (SA) on the development and severity of cerulein-induced acute pancreatitis (AP) in rats in terms of biochemical and histopathologic changes. Material and Method: 24 rats were divided into 3 equal groups. Three groups were compared in terms of the levels of oxidative stress, antioxidant markers, pancreatic enzymes, and histopathological changes. This study was approved by the ethics committee of our university and the project was supported by the scientific research unit (project number 2016 / 3-43 D). Results: In the pancreatitis group, the amylase and lipase values were significantly higher and oxidative stress markers were significantly elevated; the Glutathione peroxidase (GSH-Px) level was found to be significantly decreased in the pancreatitis group compared to the control and treatment groups. Apoptosis and cellular damage level results were significantly higher in the pancreatitis group, while cellular damage in the treatment group was significantly lower (P < 0.05) than in the pancreatitis group. Discussion: Although a syringic acid diet does not totally prevent AP, it has been shown to decrease the severity of AP on both enzymatic and histopathological levels.

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Section: Discussionmentioning

confidence: 99%

Research into the protective effect of syringic acid in rats with induced experimental pancreatitis

Sertkaya¹

2018

Ann Clin Anal Med

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“…However, no studies to date have monitored the levels of circulating Th9 cells or their infiltration into the pancreas in the context of AP. Furthermore, Merilainen et al [46] found no significant difference in serum IL-9 concentrations between experimental edematous and necrotizing pancreatitis groups and sham controls during the early course of AP. Therefore, further research is needed to clarify the potential role of Th9 cells in the pathogenesis of AP and their potential as a therapeutic target.…”

Section: Th9 Cellsmentioning

confidence: 95%

The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis

Stojanović

Jovanović

Stojanovic

et al. 2023

Cells

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Acute pancreatitis (AP) is an abrupt, variable inflammatory condition of the pancreas, potentially escalating to severe systemic inflammation, rampant pancreatic necrosis, and multi-organ failure. Its complex pathogenesis involves an intricate immune response, with different T cell subsets (Th1, Th2, Th9, Th17, Th22, TFH, Treg, and CD8+ T cells) and B cells playing pivotal roles. Early T cell activation initiates the AP development, triggering cytokines associated with the Th1 response, which stimulate macrophages and neutrophils. Other T cell phenotypes contribute to AP’s pathogenesis, and the balance between pro-inflammatory and anti-inflammatory cytokines influences its progression. Regulatory T and B cells are crucial for moderating the inflammatory response and promoting immune tolerance. B cells further contribute through antibody production, antigen presentation, and cytokine secretion. Understanding these immune cells’ roles in AP could aid in developing new immunotherapies to enhance patient outcomes. However, further research is required to define these cells’ precise roles in AP and their potential as therapeutic targets.

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“…The finding of Th9 cells initiating immunity to helminth parasites indicates the possibility of these cells regulating immune responses in AP (Licona-Limón et al, 2013). In edematous and necrotizing porcine pancreatitis models, IL-9 levels in blood do not change compared with the sham group in the early phase (Merilainen et al, 2012). However, there have not been any reports on the number or function of Th9 cells involved in initiation or progression AP.…”

Section: Th9 Cellsmentioning

confidence: 98%

Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis

Ding

Yang

Wang

et al. 2020

Front. Cell. Infect. Microbiol.

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Acute pancreatitis (AP) is considered a cascade of immune responses triggered by acinar cell necrosis. AP involves two main processes of systemic inflammatory response syndrome and subsequent compensatory anti-inflammatory response syndrome. Although great efforts have been made regarding AP therapy, the mortality rate of AP remains high. Secondary infection acts a lethal factor in AP. Lymphocytes act as major immune mediators in immune responses in the course of this disease. However, the relationship between lymphocytes and secondary infection in AP is unclear. This review summarizes the variation of lymphocytes and infection in AP. Knowledge of the characterization of circulating lymphocyte abnormalities is relevant for understanding the pathophysiology of AP.

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Portal vein cytokines in the early phase of acute experimental oedematous and necrotizing porcine pancreatitis

Abstract: The initial inflammatory process was diverse in oedematous and necrotizing pancreatitis. Increased monocyte count in combination with elevated PDGF and IL-6 are characteristic of necrotizing pancreatitis in our model.

Cited by 11 publications

References 40 publications

Research into the protective effect of syringic acid in rats with induced experimental pancreatitis

Research into the protective effect of syringic acid in rats with induced experimental pancreatitis

The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis

Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis

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