“…A number of studies have investigated combination treatment with PDGF and several other growth factors including bFGF (Meraw et al, 2000), BMP-2 (Martino et al, 2011), BMP-7 (Zhang et al, 2009b, IGF-1 (Nociti Junior et al, 2000), osteogenin (Marden et al, 1993), TGF-β1 and VEGF (El Backly et al, 2013). Bone formation was reported to increase between 1.4 and 2.3 fold (Zhang et al, 2009b) within large animals (dog (Zhang et al, 2009b)) following PDGF dosages around 5 µg/mL for direct administration (Nociti Junior et al, 2000), or 2 x 10 10 / mL viral particles for indirect administration (Zhang et al, 2009b).…”